Mechanical Ventilation Impairs IL-17 Cytokine Family Expression in Ventilator-Associated Pneumonia Article Swipe
Fien De Winter
,
Bart ‘s Jongers
,
Kenny Bielen
,
Domenico Mancuso
,
Leen Timbermont
,
Christine Lammens
,
Vincent Van averbeke
,
Jan Boddaert
,
Omar Ali
,
Jan Kluytmans
,
Alexey Ruzin
,
Surbhi Malhotra‐Kumar
,
Philippe G. Jorens
,
Herman Goossens
,
Samir Kumar‐Singh
·
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.3390/ijms20205072
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.3390/ijms20205072
Mechanical ventilation (MV) is the primary risk factor for the development of ventilator-associated pneumonia (VAP). Besides inducing a pro-inflammatory T-helper (Th)-1 cytokine response, MV also induces an anti-inflammatory Th2 cytokine response, marked by increased IL-4 secretion and reduced bacterial phagocytic capacity of rodent lung macrophages. Since IL-4 is known to downregulate both Th1 and Th17 cytokines, the latter is important in mediating mucosal immunity and combating bacterial and fungal growth, we studied and showed here in a rat model of MV that Th17 cytokines (IL-17A, IL-17F, and IL-22) were significantly upregulated in the lung as a response to different MV strategies currently utilized in clinic. To study whether the increased IL-4 levels are associated with downregulation of the anti-bacterial Th17 cytokines, we subsequently challenged mechanically ventilated rats with an intratracheal inoculation of Pseudomonas aeruginosa (VAP model) and showed a dramatic downregulation of IL-17A, IL-17F, and IL-22, compared to animals receiving the same bacterial burden without MV. For the studied Th1 cytokines (IFNγ, TNFα, IL-6, and IL-1β), only IFNγ showed a significant decrease as a consequence of bacterial infection in mechanically ventilated rats. We further studied IL-17A, the most studied IL-17 family member, in intensive care unit (ICU) pneumonia patients and showed that VAP patients had significantly lower levels of IL-17A in the endotracheal aspirate compared to patients entering ICU with pre-existing pneumonia. These translational data, obtained both in animal models and in humans, suggest that a deficient anti-bacterial Th17 response in the lung during MV is associated with VAP development.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/ijms20205072
- https://www.mdpi.com/1422-0067/20/20/5072/pdf
- OA Status
- gold
- Cited By
- 21
- References
- 52
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2979511281
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- OpenAlex ID
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https://openalex.org/W2979511281Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/ijms20205072Digital Object Identifier
- Title
-
Mechanical Ventilation Impairs IL-17 Cytokine Family Expression in Ventilator-Associated PneumoniaWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2019Year of publication
- Publication date
-
2019-10-12Full publication date if available
- Authors
-
Fien De Winter, Bart ‘s Jongers, Kenny Bielen, Domenico Mancuso, Leen Timbermont, Christine Lammens, Vincent Van averbeke, Jan Boddaert, Omar Ali, Jan Kluytmans, Alexey Ruzin, Surbhi Malhotra‐Kumar, Philippe G. Jorens, Herman Goossens, Samir Kumar‐SinghList of authors in order
- Landing page
-
https://doi.org/10.3390/ijms20205072Publisher landing page
- PDF URL
-
https://www.mdpi.com/1422-0067/20/20/5072/pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/1422-0067/20/20/5072/pdfDirect OA link when available
- Concepts
-
Downregulation and upregulation, Cytokine, Pneumonia, Medicine, Immunology, Mechanical ventilation, Ventilator-associated pneumonia, Bacterial pneumonia, Lung, Interleukin, Interleukin 6, Proinflammatory cytokine, Tumor necrosis factor alpha, Inflammation, Biology, Internal medicine, Gene, BiochemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
21Total citation count in OpenAlex
- Citations by year (recent)
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2025: 5, 2024: 2, 2023: 2, 2022: 4, 2021: 4Per-year citation counts (last 5 years)
- References (count)
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52Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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