Mechanism-of-Action Classification of Antibiotics by Global Transcriptome Profiling Article Swipe
Aubrie O’Rourke
,
Sinem Beyhan
,
Yongwook Choi
,
Pavel Morales
,
Agnes P. Chan
,
Josh L. Espinoza
,
Christopher L. Dupont
,
Kirsten J. Meyer
,
Amy L. Spoering
,
Kim Lewis
,
William C. Nierman
,
William Nelson
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1128/aac.01207-19
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1128/aac.01207-19
Antimicrobial resistance (AMR) is an ever-growing public health problem worldwide. The low rate of antibiotic discovery coupled with the rapid spread of drug-resistant bacterial pathogens is causing a global health crisis. To facilitate the drug discovery processes, we present a large-scale study of reference antibiotic challenge bacterial transcriptome profiles, which included 37 antibiotics across 6 mechanisms of actions (MOAs) and provide an economical approach to aid in antimicrobial dereplication in the discovery process.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1128/aac.01207-19
- OA Status
- hybrid
- Cited By
- 104
- References
- 26
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2999866742
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2999866742Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1128/aac.01207-19Digital Object Identifier
- Title
-
Mechanism-of-Action Classification of Antibiotics by Global Transcriptome ProfilingWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2020Year of publication
- Publication date
-
2020-01-07Full publication date if available
- Authors
-
Aubrie O’Rourke, Sinem Beyhan, Yongwook Choi, Pavel Morales, Agnes P. Chan, Josh L. Espinoza, Christopher L. Dupont, Kirsten J. Meyer, Amy L. Spoering, Kim Lewis, William C. Nierman, William NelsonList of authors in order
- Landing page
-
https://doi.org/10.1128/aac.01207-19Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.1128/aac.01207-19Direct OA link when available
- Concepts
-
Transcriptome, Antibiotics, Computational biology, Biology, Drug discovery, Antimicrobial, Antibiotic resistance, Gene expression profiling, Gene, Profiling (computer programming), Drug resistance, Gene expression, Bioinformatics, Genetics, Microbiology, Computer science, Operating systemTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
104Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 13, 2024: 23, 2023: 16, 2022: 22, 2021: 24Per-year citation counts (last 5 years)
- References (count)
-
26Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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