Mechanism of action of Aloe vera against human papillomavirus‑positive head and neck squamous cell carcinoma Article Swipe
Kunpeng Zhu
,
Yangyang Han
,
Yunyun Zhu
,
Xiumei Zhu
,
Shiqi Huang
,
Kunpeng Wang
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3892/ol.2025.15221
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3892/ol.2025.15221
The present study aimed to evaluate the therapeutic targets of Aloe vera against human papillomavirus-positive (HPV+) head and neck squamous cell carcinoma (HNSCC), focusing on key bioactive components and their impact on molecular pathways, gene expression, overall survival and the tumor immune microenvironment. Using network pharmacology analysis, eight bioactive components of Aloe vera were identified, along with 244 corresponding potential therapeutic targets. Differential gene expression analysis of the GSE53355 and GSE117973 datasets revealed HPV+ HNSCC-specific genes. Using topological analysis of protein-protein interaction networks, serpin family member 1 (SERPINE1) was determined to be the core gene. Gene expression data were validated and survival analysis was performed, alongside molecular docking and experimental validation in HPV+ HNSCC cells. SERPINE1 was identified as a key gene that was markedly upregulated in HPV+ HNSCC, with a strong association with worse overall survival (P<0.0001). Genetic alterations in SERPINE1, primarily arm-level gains, were associated with immune cell infiltration, suggesting a role in tumorigenesis. Gene Set Enrichment Analysis showed the involvement of SERPINE1 in crucial cancer-associated pathways. Quercetin and SERPINE1 have strong binding affinity, as demonstrated by molecular docking, with experimental validation showing dose-dependent downregulation of SERPINE1 in HPV+ HNSCC cells. In conclusion, the bioactive component of Aloe vera, quercetin, exhibits potential in specifically targeting SERPINE1. The present discovery offers a potential therapeutic strategy for HPV+ HNSCC, particularly for enhancing patient survival outcomes. However, further in-depth investigations are essential to validate its therapeutic efficacy and underlying mechanisms within the intricate tumor microenvironment in vivo.
Related Topics
Concepts
Human papillomavirus
Basal cell
Head and neck
Oncogene
Medicine
Mechanism (biology)
Head and neck squamous-cell carcinoma
Cancer
Head and neck cancer
Cancer research
Oncology
Internal medicine
Cell cycle
Surgery
Epistemology
Philosophy
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3892/ol.2025.15221
- OA Status
- diamond
- References
- 40
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4413229193
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4413229193Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3892/ol.2025.15221Digital Object Identifier
- Title
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Mechanism of action of Aloe vera against human papillomavirus‑positive head and neck squamous cell carcinomaWork title
- Type
-
articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2025Year of publication
- Publication date
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2025-08-11Full publication date if available
- Authors
-
Kunpeng Zhu, Yangyang Han, Yunyun Zhu, Xiumei Zhu, Shiqi Huang, Kunpeng WangList of authors in order
- Landing page
-
https://doi.org/10.3892/ol.2025.15221Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
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diamondOpen access status per OpenAlex
- OA URL
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https://doi.org/10.3892/ol.2025.15221Direct OA link when available
- Concepts
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Human papillomavirus, Basal cell, Head and neck, Oncogene, Medicine, Mechanism (biology), Head and neck squamous-cell carcinoma, Cancer, Head and neck cancer, Cancer research, Oncology, Internal medicine, Cell cycle, Surgery, Epistemology, PhilosophyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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40Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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