Mechanism of RNA-binding protein Lin28 in neuronal ferroptosis after intracerebral haemorrhage Article Swipe
Luqian Feng
,
Likun Wang
,
Guofeng Wu
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.5114/fn.2022.114101
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.5114/fn.2022.114101
Intracerebral haemorrhage (ICH) is a highly risky cerebrovascular disease with poor prognosis. Lin-28 homolog A (Lin28) has been identified as a crucial regulator in ICH. This study aims to analyse the mechanism of Lin28 in neuronal ferroptosis after ICH and provide theoretical basis for ICH treatment. An ICH mouse model was established via injection of collagenase VII, followed by neurological impairment assessment, and haematoxylin-eosin staining. An in vitro ICH model was established using hemin treatment. Next, cell viability and ferroptosis parameters were detected via cell counting kit-8, assay kits, enzyme-linked immunosorbent assay and western blot. Lin28 expression and tripartite motif-containing 37 (Trim37) mRNA level were detected via western blot and quantitative real-time polymerase chain reaction (qRT-PCR). The binding relationship of Lin28 and Trim37 was verified. ICH mice exhibited neuronal ferroptosis and upregulation of Lin28. Lin28 inhibition alleviated neurological impairment, manifested by decreased hematoma, oedema, neuronal necrosis, glial cell swelling, intracellular vacuoles and inflammatory cell infiltration, reduced Fe2+ concentration and reactive oxygen species content, and increased glutathione and glutathione peroxidase 4 activity. In the hemin-induced HT-22 cells, Lin28 inhibition promoted cell viability and alleviated neuronal ferroptosis. Lin28 bound to Trim37 mRNA to stabilize the mRNA level of Trim37. Overexpression of Trim37 reversed the alleviating role of silencing Lin28 in neuronal ferroptosis after ICH. Overall, Lin28 stabilized the mRNA level of Trim37 to aggravate neuronal ferroptosis after ICH.
Related Topics
Concepts
Viability assay
Chemistry
LIN28
Western blot
Cold-shock domain
Molecular biology
Cell
Biochemistry
Biology
RNA
Transcription factor
Gene
SOX2
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.5114/fn.2022.114101
- https://www.termedia.pl/Journal/-20/pdf-46504-10?filename=Mechanism.pdf
- OA Status
- diamond
- Cited By
- 4
- References
- 30
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4226125419
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4226125419Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.5114/fn.2022.114101Digital Object Identifier
- Title
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Mechanism of RNA-binding protein Lin28 in neuronal ferroptosis after intracerebral haemorrhageWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-01-01Full publication date if available
- Authors
-
Luqian Feng, Likun Wang, Guofeng WuList of authors in order
- Landing page
-
https://doi.org/10.5114/fn.2022.114101Publisher landing page
- PDF URL
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https://www.termedia.pl/Journal/-20/pdf-46504-10?filename=Mechanism.pdfDirect link to full text PDF
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YesWhether a free full text is available
- OA status
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diamondOpen access status per OpenAlex
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https://www.termedia.pl/Journal/-20/pdf-46504-10?filename=Mechanism.pdfDirect OA link when available
- Concepts
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Viability assay, Chemistry, LIN28, Western blot, Cold-shock domain, Molecular biology, Cell, Biochemistry, Biology, RNA, Transcription factor, Gene, SOX2Top concepts (fields/topics) attached by OpenAlex
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4Total citation count in OpenAlex
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2024: 1, 2023: 3Per-year citation counts (last 5 years)
- References (count)
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30Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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