Mechanisms of a Mycobacterium tuberculosis Active Peptide Article Swipe
Komal Umashankar Rao
,
Ping Li
,
Charlotte Welinder
,
Erik Tenland
,
Pontus Gourdon
,
Erik Sturegård
,
James C. S. Ho
,
Gabriela Godaly
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/pharmaceutics15020540
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/pharmaceutics15020540
Multidrug-resistant tuberculosis (MDR) continues to pose a threat to public health. Previously, we identified a cationic host defense peptide with activity against Mycobacterium tuberculosis in vivo and with a bactericidal effect against MDR M. tuberculosis at therapeutic concentrations. To understand the mechanisms of this peptide, we investigated its interactions with live M. tuberculosis and liposomes as a model. Peptide interactions with M. tuberculosis inner membranes induced tube-shaped membranous structures and massive vesicle formation, thus leading to bubbling cell death and ghost cell formation. Liposomal studies revealed that peptide insertion into inner membranes induced changes in the peptides’ secondary structure and that the membranes were pulled such that they aggregated without permeabilization, suggesting that the peptide has a strong inner membrane affinity. Finally, the peptide targeted essential proteins in M. tuberculosis, such as 60 kDa chaperonins and elongation factor Tu, that are involved in mycolic acid synthesis and protein folding, which had an impact on bacterial proliferation. The observed multifaceted targeting provides additional support for the therapeutic potential of this peptide.
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Metadata
- Type
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- Language
- en
- Landing Page
- https://doi.org/10.3390/pharmaceutics15020540
- https://www.mdpi.com/1999-4923/15/2/540/pdf?version=1676873065
- OA Status
- gold
- Cited By
- 14
- References
- 52
- Related Works
- 10
- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W4319442458Canonical identifier for this work in OpenAlex
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https://doi.org/10.3390/pharmaceutics15020540Digital Object Identifier
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Mechanisms of a Mycobacterium tuberculosis Active PeptideWork title
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articleOpenAlex work type
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enPrimary language
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2023Year of publication
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2023-02-06Full publication date if available
- Authors
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Komal Umashankar Rao, Ping Li, Charlotte Welinder, Erik Tenland, Pontus Gourdon, Erik Sturegård, James C. S. Ho, Gabriela GodalyList of authors in order
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https://doi.org/10.3390/pharmaceutics15020540Publisher landing page
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https://www.mdpi.com/1999-4923/15/2/540/pdf?version=1676873065Direct link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.mdpi.com/1999-4923/15/2/540/pdf?version=1676873065Direct OA link when available
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Mycobacterium tuberculosis, Peptide, Liposome, Membrane, Tuberculosis, Chemistry, Biology, Microbiology, Biochemistry, Cell biology, Medicine, PathologyTop concepts (fields/topics) attached by OpenAlex
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14Total citation count in OpenAlex
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2025: 3, 2024: 1, 2023: 10Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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