Mechanistic insights into adipose-derived stem cells and exosomes in ischemia-reperfusion injury repair: from shared pathways to organ-specific therapeutics Article Swipe
Jiawen Si
,
Jie Wang
,
Hao Dai
,
Tongde Lv
,
Songyun Zhao
,
Wanying Chen
,
Liqun Li
,
Siqi Ding
,
Yucang He
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3389/fcell.2025.1621289
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3389/fcell.2025.1621289
Ischemia-reperfusion injury (IRI) has become a significant challenge for clinical treatment due to the complex multi-mechanism pathological cascade response, including oxidative stress, inflammatory bursts, and programmed cell death. Adipose-derived stem cells (ADSCs) and their exosomes (ADSCs-exosomes) are emerging as a breakthrough therapeutic strategy to reverse IRI, owing to their multi-target synergistic effects. This review systematically analyzes the two major repair modes of ADSCs and ADSCs-exosomes: the “common protection” mechanism, which includes anti-inflammatory, anti-oxidative, and anti-apoptotic effects through paracrine regulation of miRNAs targeting the NF-κB/NRF2/β-catenin signaling axis; and precision repair, which is achieved through organ-specific targets, including hepatic mitochondrial dynamics and pyroptosis inhibition, cardiac macrophage polarization and neutrophil clearance, renal anti-fibrosis and erythropoietin (EPO) activation, as well as brain iron death regulation and microglial remodeling. From the perspective of the mechanism interaction network, this paper first proposes a theoretical framework of “multi-organ shared core pathways and dynamic regulation of different targets.” It also reviews the translational potential of combined therapeutic strategies based on engineered exosomes delivery systems and biomaterials, emphasizing the optimization of delivery efficiency and functional enhancement to address the bottleneck of clinical applications. The ADSCs-mediated IRI intervention system provides an essential theoretical and technical basis for the development of individualized precision therapies.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3389/fcell.2025.1621289
- https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2025.1621289/pdf
- OA Status
- gold
- References
- 92
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4411500929
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4411500929Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fcell.2025.1621289Digital Object Identifier
- Title
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Mechanistic insights into adipose-derived stem cells and exosomes in ischemia-reperfusion injury repair: from shared pathways to organ-specific therapeuticsWork title
- Type
-
reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-06-20Full publication date if available
- Authors
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Jiawen Si, Jie Wang, Hao Dai, Tongde Lv, Songyun Zhao, Wanying Chen, Liqun Li, Siqi Ding, Yucang HeList of authors in order
- Landing page
-
https://doi.org/10.3389/fcell.2025.1621289Publisher landing page
- PDF URL
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https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2025.1621289/pdfDirect link to full text PDF
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
- OA URL
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https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2025.1621289/pdfDirect OA link when available
- Concepts
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Microvesicles, Adipose tissue, Stem cell, Ischemia, Biology, Reperfusion injury, Cell biology, microRNA, Bioinformatics, Computational biology, Medicine, Neuroscience, Genetics, Gene, Internal medicine, EndocrinologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
- References (count)
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92Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| cited_by_percentile_year | |
| countries_distinct_count | 1 |
| institutions_distinct_count | 9 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.7599999904632568 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.23837644 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |