Mediation of the association between education and dementia by occupational complexity, income, health behaviours and health outcomes Article Swipe
YOU?
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· 2025
· Open Access
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· DOI: https://doi.org/10.1186/s12888-025-06619-4
Background Many studies observe a negative association between education and all-cause dementia, however, little is known about how the association develops. Current evidence regarding mediatory factors is limited, conflicted and suggests a complex relationship. In this study we used UK Biobank data to determine to what extent multiple factors mediate the association. Methods Data was sourced from UK Biobank and multiple imputation used to replace missing values. Education was measured at baseline assessment and dementia diagnosis determined from self-report or linked healthcare records. Five potential mediators were considered: Social isolation, income and occupational complexity were measured at baseline and health behaviour and health outcome scores derived. Logistic regression was used to examine the association between education and dementia with adjustment for potential mediators. Causal mediation analysis was then performed to determine the proportion of the dementia education association occurring via each mediatory pathway. Results In a sample of 384,284 participants, higher level of education was associated with reduced odds of dementia. When considered as a confounder, occupational complexity almost fully attenuated the association (OR: 0.94, CI: 0.89–0.99) and was found to mediate 73% of the association. Average income, health outcomes and health behaviours also acted as mediators, explaining 10%, 27% and 35% of the relationship respectively. Conclusions Occupational complexity mediates a large proportion of the association between education and dementia. Intervention to improve access to cognitively stimulating work and leisure activities, particularly to those who are less educated, may reduce the number of people in the UK living with dementia.
Related Topics
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1186/s12888-025-06619-4
- https://bmcpsychiatry.biomedcentral.com/counter/pdf/10.1186/s12888-025-06619-4
- OA Status
- gold
- Cited By
- 1
- References
- 53
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4407944468
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4407944468Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1186/s12888-025-06619-4Digital Object Identifier
- Title
-
Mediation of the association between education and dementia by occupational complexity, income, health behaviours and health outcomesWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-02-25Full publication date if available
- Authors
-
Katherine Taylor, Louise Marston, Naaheed MukadamList of authors in order
- Landing page
-
https://doi.org/10.1186/s12888-025-06619-4Publisher landing page
- PDF URL
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https://bmcpsychiatry.biomedcentral.com/counter/pdf/10.1186/s12888-025-06619-4Direct link to full text PDF
- Open access
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YesWhether a free full text is available
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-
goldOpen access status per OpenAlex
- OA URL
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https://bmcpsychiatry.biomedcentral.com/counter/pdf/10.1186/s12888-025-06619-4Direct OA link when available
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Mediation, Dementia, Association (psychology), Psychology, Psychiatry, Clinical psychology, Medicine, Psychotherapist, Disease, Political science, Law, PathologyTop concepts (fields/topics) attached by OpenAlex
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1Total citation count in OpenAlex
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2025: 1Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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