Mediator and RNA polymerase II clusters associate in transcription-dependent condensates Article Swipe
Won‐Ki Cho
,
Jan-Hendrik Spille
,
Micca Hecht
,
Choongman Lee
,
Charles H. Li
,
Valentin Grube
,
Ibrahim I. Cissé
·
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.1126/science.aar4199
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.1126/science.aar4199
Phase separation and gene control Many components of eukaryotic transcription machinery—such as transcription factors and cofactors including BRD4, subunits of the Mediator complex, and RNA polymerase II—contain intrinsically disordered low-complexity domains. Now a conceptual framework connecting the nature and behavior of their interactions to their functions in transcription regulation is emerging (see the Perspective by Plys and Kingston). Chong et al. found that low-complexity domains of transcription factors form concentrated hubs via functionally relevant dynamic, multivalent, and sequence-specific protein-protein interaction. These hubs have the potential to phase-separate at higher concentrations. Indeed, Sabari et al. showed that at super-enhancers, BRD4 and Mediator form liquid-like condensates that compartmentalize and concentrate the transcription apparatus to maintain expression of key cell-identity genes. Cho et al. further revealed the differential sensitivity of Mediator and RNA polymerase II condensates to selective transcription inhibitors and how their dynamic interactions might initiate transcription elongation. Science , this issue p. eaar2555 , p. eaar3958 , p. 412 ; see also p. 329
Related Topics
Concepts
RNA polymerase II
Mediator
Chromatin
Enhancer
Transcription (linguistics)
Cell biology
Coactivator
Biology
RNA polymerase
Polymerase
Gene
RNA
Genetics
Promoter
Transcription factor
Gene expression
Linguistics
Philosophy
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1126/science.aar4199
- OA Status
- green
- Cited By
- 1409
- References
- 43
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2809265915
All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W2809265915Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1126/science.aar4199Digital Object Identifier
- Title
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Mediator and RNA polymerase II clusters associate in transcription-dependent condensatesWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2018Year of publication
- Publication date
-
2018-06-21Full publication date if available
- Authors
-
Won‐Ki Cho, Jan-Hendrik Spille, Micca Hecht, Choongman Lee, Charles H. Li, Valentin Grube, Ibrahim I. CisséList of authors in order
- Landing page
-
https://doi.org/10.1126/science.aar4199Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
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https://www.ncbi.nlm.nih.gov/pmc/articles/6543815Direct OA link when available
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RNA polymerase II, Mediator, Chromatin, Enhancer, Transcription (linguistics), Cell biology, Coactivator, Biology, RNA polymerase, Polymerase, Gene, RNA, Genetics, Promoter, Transcription factor, Gene expression, Linguistics, PhilosophyTop concepts (fields/topics) attached by OpenAlex
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1409Total citation count in OpenAlex
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2025: 179, 2024: 178, 2023: 211, 2022: 198, 2021: 262Per-year citation counts (last 5 years)
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43Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.cell-identity | 116 |
| abstract_inverted_index.intrinsically | 27 |
| abstract_inverted_index.transcription | 9, 12, 47, 66, 109, 135, 144 |
| abstract_inverted_index.low-complexity | 29, 63 |
| abstract_inverted_index.phase-separate | 86 |
| abstract_inverted_index.concentrations. | 89 |
| abstract_inverted_index.protein-protein | 78 |
| abstract_inverted_index.compartmentalize | 105 |
| abstract_inverted_index.machinery—such | 10 |
| abstract_inverted_index.super-enhancers, | 97 |
| abstract_inverted_index.sequence-specific | 77 |
| cited_by_percentile_year.max | 100 |
| cited_by_percentile_year.min | 94 |
| corresponding_author_ids | https://openalex.org/A5089223715, https://openalex.org/A5068567440, https://openalex.org/A5051885967 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 7 |
| corresponding_institution_ids | https://openalex.org/I4210110987 |
| citation_normalized_percentile.value | 0.99979386 |
| citation_normalized_percentile.is_in_top_1_percent | True |
| citation_normalized_percentile.is_in_top_10_percent | True |