Megadalton-sized Dityrosine Aggregates of α-Synuclein Retain High Degrees of Structural Disorder and Internal Dynamics Article Swipe
Silvia Verzini
,
Maliha Shah
,
François‐Xavier Theillet
,
Adam Belsom
,
Jan Bieschke
,
Erich E. Wanker
,
Juri Rappsilber
,
Andrés Binolfi
,
Philipp Selenko
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1016/j.jmb.2020.10.023
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1016/j.jmb.2020.10.023
Heterogeneous aggregates of the human protein α-synuclein (αSyn) are abundantly found in Lewy body inclusions of Parkinson's disease patients. While structural information on classical αSyn amyloid fibrils is available, little is known about the conformational properties of disease-relevant, non-canonical aggregates. Here, we analyze the structural and dynamic properties of megadalton-sized dityrosine adducts of αSyn that form in the presence of reactive oxygen species and cytochrome c, a proapoptotic peroxidase that is released from mitochondria during sustained oxidative stress. In contrast to canonical cross-β amyloids, these aggregates retain high degrees of internal dynamics, which enables their characterization by solution-state NMR spectroscopy. We find that intermolecular dityrosine crosslinks restrict αSyn motions only locally whereas large segments of concatenated molecules remain flexible and disordered. Indistinguishable aggregates form in crowded in vitro solutions and in complex environments of mammalian cell lysates, where relative amounts of free reactive oxygen species, rather than cytochrome c, are rate limiting. We further establish that dityrosine adducts inhibit classical amyloid formation by maintaining αSyn in its monomeric form and that they are non-cytotoxic despite retaining basic membrane-binding properties. Our results suggest that oxidative αSyn aggregation scavenges cytochrome c's activity into the formation of amorphous, high molecular-weight structures that may contribute to the structural diversity of Lewy body deposits.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.jmb.2020.10.023
- https://www.sciencedirect.com/science/article/pii/S0022283620305982?via%3Dihub
- OA Status
- hybrid
- Cited By
- 6
- References
- 66
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3094247061
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3094247061Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1016/j.jmb.2020.10.023Digital Object Identifier
- Title
-
Megadalton-sized Dityrosine Aggregates of α-Synuclein Retain High Degrees of Structural Disorder and Internal DynamicsWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2020Year of publication
- Publication date
-
2020-10-22Full publication date if available
- Authors
-
Silvia Verzini, Maliha Shah, François‐Xavier Theillet, Adam Belsom, Jan Bieschke, Erich E. Wanker, Juri Rappsilber, Andrés Binolfi, Philipp SelenkoList of authors in order
- Landing page
-
https://doi.org/10.1016/j.jmb.2020.10.023Publisher landing page
- PDF URL
-
https://www.sciencedirect.com/science/article/pii/S0022283620305982?via%3DihubDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
-
https://www.sciencedirect.com/science/article/pii/S0022283620305982?via%3DihubDirect OA link when available
- Concepts
-
Chemistry, Amyloid (mycology), Cytochrome, Biophysics, Protein aggregation, Reactive oxygen species, Cytochrome c, Monomer, Alpha-synuclein, Oxidative stress, Mitochondrion, Biochemistry, Biology, Parkinson's disease, Enzyme, Organic chemistry, Disease, Medicine, Pathology, Polymer, Inorganic chemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
6Total citation count in OpenAlex
- Citations by year (recent)
-
2022: 4, 2021: 1, 2020: 1Per-year citation counts (last 5 years)
- References (count)
-
66Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W3094247061 |
|---|---|
| doi | https://doi.org/10.1016/j.jmb.2020.10.023 |
| ids.doi | https://doi.org/10.1016/j.jmb.2020.10.023 |
| ids.mag | 3094247061 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/33211011 |
| ids.openalex | https://openalex.org/W3094247061 |
| fwci | 0.94181316 |
| mesh[0].qualifier_ui | Q000737 |
| mesh[0].descriptor_ui | D000682 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | chemistry |
| mesh[0].descriptor_name | Amyloid |
| mesh[1].qualifier_ui | Q000235 |
| mesh[1].descriptor_ui | D000682 |
| mesh[1].is_major_topic | False |
| mesh[1].qualifier_name | genetics |
| mesh[1].descriptor_name | Amyloid |
| mesh[2].qualifier_ui | Q000648 |
| mesh[2].descriptor_ui | D000682 |
| mesh[2].is_major_topic | False |
| mesh[2].qualifier_name | ultrastructure |
| mesh[2].descriptor_name | Amyloid |
| mesh[3].qualifier_ui | Q000235 |
| mesh[3].descriptor_ui | D016229 |
| mesh[3].is_major_topic | False |
| mesh[3].qualifier_name | genetics |
| mesh[3].descriptor_name | Amyloid beta-Peptides |
| mesh[4].qualifier_ui | Q000235 |
| mesh[4].descriptor_ui | D045304 |
| mesh[4].is_major_topic | False |
| mesh[4].qualifier_name | genetics |
| mesh[4].descriptor_name | Cytochromes c |
| mesh[5].qualifier_ui | |
| mesh[5].descriptor_ui | D006801 |
| mesh[5].is_major_topic | False |
| mesh[5].qualifier_name | |
| mesh[5].descriptor_name | Humans |
| mesh[6].qualifier_ui | |
| mesh[6].descriptor_ui | D009682 |
| mesh[6].is_major_topic | False |
| mesh[6].qualifier_name | |
| mesh[6].descriptor_name | Magnetic Resonance Spectroscopy |
| mesh[7].qualifier_ui | Q000235 |
| mesh[7].descriptor_ui | D008928 |
| mesh[7].is_major_topic | False |
| mesh[7].qualifier_name | genetics |
| mesh[7].descriptor_name | Mitochondria |
| mesh[8].qualifier_ui | Q000378 |
| mesh[8].descriptor_ui | D008928 |
| mesh[8].is_major_topic | False |
| mesh[8].qualifier_name | metabolism |
| mesh[8].descriptor_name | Mitochondria |
| mesh[9].qualifier_ui | Q000378 |
| mesh[9].descriptor_ui | D009474 |
| mesh[9].is_major_topic | False |
| mesh[9].qualifier_name | metabolism |
| mesh[9].descriptor_name | Neurons |
| mesh[10].qualifier_ui | Q000473 |
| mesh[10].descriptor_ui | D009474 |
| mesh[10].is_major_topic | False |
| mesh[10].qualifier_name | pathology |
| mesh[10].descriptor_name | Neurons |
| mesh[11].qualifier_ui | Q000648 |
| mesh[11].descriptor_ui | D009474 |
| mesh[11].is_major_topic | False |
| mesh[11].qualifier_name | ultrastructure |
| mesh[11].descriptor_name | Neurons |
| mesh[12].qualifier_ui | Q000235 |
| mesh[12].descriptor_ui | D018384 |
| mesh[12].is_major_topic | False |
| mesh[12].qualifier_name | genetics |
| mesh[12].descriptor_name | Oxidative Stress |
| mesh[13].qualifier_ui | Q000235 |
| mesh[13].descriptor_ui | D010300 |
| mesh[13].is_major_topic | False |
| mesh[13].qualifier_name | genetics |
| mesh[13].descriptor_name | Parkinson Disease |
| mesh[14].qualifier_ui | Q000473 |
| mesh[14].descriptor_ui | D010300 |
| mesh[14].is_major_topic | False |
| mesh[14].qualifier_name | pathology |
| mesh[14].descriptor_name | Parkinson Disease |
| mesh[15].qualifier_ui | Q000235 |
| mesh[15].descriptor_ui | D066329 |
| mesh[15].is_major_topic | False |
| mesh[15].qualifier_name | genetics |
| mesh[15].descriptor_name | Protein Aggregates |
| mesh[16].qualifier_ui | |
| mesh[16].descriptor_ui | D011487 |
| mesh[16].is_major_topic | False |
| mesh[16].qualifier_name | |
| mesh[16].descriptor_name | Protein Conformation |
| mesh[17].qualifier_ui | Q000378 |
| mesh[17].descriptor_ui | D017382 |
| mesh[17].is_major_topic | False |
| mesh[17].qualifier_name | metabolism |
| mesh[17].descriptor_name | Reactive Oxygen Species |
| mesh[18].qualifier_ui | Q000031 |
| mesh[18].descriptor_ui | D014443 |
| mesh[18].is_major_topic | False |
| mesh[18].qualifier_name | analogs & derivatives |
| mesh[18].descriptor_name | Tyrosine |
| mesh[19].qualifier_ui | Q000737 |
| mesh[19].descriptor_ui | D014443 |
| mesh[19].is_major_topic | False |
| mesh[19].qualifier_name | chemistry |
| mesh[19].descriptor_name | Tyrosine |
| mesh[20].qualifier_ui | Q000235 |
| mesh[20].descriptor_ui | D014443 |
| mesh[20].is_major_topic | False |
| mesh[20].qualifier_name | genetics |
| mesh[20].descriptor_name | Tyrosine |
| mesh[21].qualifier_ui | Q000235 |
| mesh[21].descriptor_ui | D051844 |
| mesh[21].is_major_topic | False |
| mesh[21].qualifier_name | genetics |
| mesh[21].descriptor_name | alpha-Synuclein |
| mesh[22].qualifier_ui | Q000648 |
| mesh[22].descriptor_ui | D051844 |
| mesh[22].is_major_topic | False |
| mesh[22].qualifier_name | ultrastructure |
| mesh[22].descriptor_name | alpha-Synuclein |
| mesh[23].qualifier_ui | Q000737 |
| mesh[23].descriptor_ui | D000682 |
| mesh[23].is_major_topic | False |
| mesh[23].qualifier_name | chemistry |
| mesh[23].descriptor_name | Amyloid |
| mesh[24].qualifier_ui | Q000235 |
| mesh[24].descriptor_ui | D000682 |
| mesh[24].is_major_topic | False |
| mesh[24].qualifier_name | genetics |
| mesh[24].descriptor_name | Amyloid |
| mesh[25].qualifier_ui | Q000648 |
| mesh[25].descriptor_ui | D000682 |
| mesh[25].is_major_topic | False |
| mesh[25].qualifier_name | ultrastructure |
| mesh[25].descriptor_name | Amyloid |
| mesh[26].qualifier_ui | Q000235 |
| mesh[26].descriptor_ui | D016229 |
| mesh[26].is_major_topic | False |
| mesh[26].qualifier_name | genetics |
| mesh[26].descriptor_name | Amyloid beta-Peptides |
| mesh[27].qualifier_ui | Q000235 |
| mesh[27].descriptor_ui | D045304 |
| mesh[27].is_major_topic | False |
| mesh[27].qualifier_name | genetics |
| mesh[27].descriptor_name | Cytochromes c |
| mesh[28].qualifier_ui | |
| mesh[28].descriptor_ui | D006801 |
| mesh[28].is_major_topic | False |
| mesh[28].qualifier_name | |
| mesh[28].descriptor_name | Humans |
| mesh[29].qualifier_ui | |
| mesh[29].descriptor_ui | D009682 |
| mesh[29].is_major_topic | False |
| mesh[29].qualifier_name | |
| mesh[29].descriptor_name | Magnetic Resonance Spectroscopy |
| mesh[30].qualifier_ui | Q000235 |
| mesh[30].descriptor_ui | D008928 |
| mesh[30].is_major_topic | False |
| mesh[30].qualifier_name | genetics |
| mesh[30].descriptor_name | Mitochondria |
| mesh[31].qualifier_ui | Q000378 |
| mesh[31].descriptor_ui | D008928 |
| mesh[31].is_major_topic | False |
| mesh[31].qualifier_name | metabolism |
| mesh[31].descriptor_name | Mitochondria |
| mesh[32].qualifier_ui | Q000378 |
| mesh[32].descriptor_ui | D009474 |
| mesh[32].is_major_topic | False |
| mesh[32].qualifier_name | metabolism |
| mesh[32].descriptor_name | Neurons |
| mesh[33].qualifier_ui | Q000473 |
| mesh[33].descriptor_ui | D009474 |
| mesh[33].is_major_topic | False |
| mesh[33].qualifier_name | pathology |
| mesh[33].descriptor_name | Neurons |
| mesh[34].qualifier_ui | Q000648 |
| mesh[34].descriptor_ui | D009474 |
| mesh[34].is_major_topic | False |
| mesh[34].qualifier_name | ultrastructure |
| mesh[34].descriptor_name | Neurons |
| mesh[35].qualifier_ui | Q000235 |
| mesh[35].descriptor_ui | D018384 |
| mesh[35].is_major_topic | False |
| mesh[35].qualifier_name | genetics |
| mesh[35].descriptor_name | Oxidative Stress |
| mesh[36].qualifier_ui | Q000235 |
| mesh[36].descriptor_ui | D010300 |
| mesh[36].is_major_topic | False |
| mesh[36].qualifier_name | genetics |
| mesh[36].descriptor_name | Parkinson Disease |
| mesh[37].qualifier_ui | Q000473 |
| mesh[37].descriptor_ui | D010300 |
| mesh[37].is_major_topic | False |
| mesh[37].qualifier_name | pathology |
| mesh[37].descriptor_name | Parkinson Disease |
| mesh[38].qualifier_ui | Q000235 |
| mesh[38].descriptor_ui | D066329 |
| mesh[38].is_major_topic | False |
| mesh[38].qualifier_name | genetics |
| mesh[38].descriptor_name | Protein Aggregates |
| mesh[39].qualifier_ui | |
| mesh[39].descriptor_ui | D011487 |
| mesh[39].is_major_topic | False |
| mesh[39].qualifier_name | |
| mesh[39].descriptor_name | Protein Conformation |
| mesh[40].qualifier_ui | Q000378 |
| mesh[40].descriptor_ui | D017382 |
| mesh[40].is_major_topic | False |
| mesh[40].qualifier_name | metabolism |
| mesh[40].descriptor_name | Reactive Oxygen Species |
| mesh[41].qualifier_ui | Q000031 |
| mesh[41].descriptor_ui | D014443 |
| mesh[41].is_major_topic | False |
| mesh[41].qualifier_name | analogs & derivatives |
| mesh[41].descriptor_name | Tyrosine |
| mesh[42].qualifier_ui | Q000737 |
| mesh[42].descriptor_ui | D014443 |
| mesh[42].is_major_topic | False |
| mesh[42].qualifier_name | chemistry |
| mesh[42].descriptor_name | Tyrosine |
| mesh[43].qualifier_ui | Q000235 |
| mesh[43].descriptor_ui | D014443 |
| mesh[43].is_major_topic | False |
| mesh[43].qualifier_name | genetics |
| mesh[43].descriptor_name | Tyrosine |
| mesh[44].qualifier_ui | Q000235 |
| mesh[44].descriptor_ui | D051844 |
| mesh[44].is_major_topic | False |
| mesh[44].qualifier_name | genetics |
| mesh[44].descriptor_name | alpha-Synuclein |
| mesh[45].qualifier_ui | Q000648 |
| mesh[45].descriptor_ui | D051844 |
| mesh[45].is_major_topic | False |
| mesh[45].qualifier_name | ultrastructure |
| mesh[45].descriptor_name | alpha-Synuclein |
| mesh[46].qualifier_ui | Q000737 |
| mesh[46].descriptor_ui | D000682 |
| mesh[46].is_major_topic | False |
| mesh[46].qualifier_name | chemistry |
| mesh[46].descriptor_name | Amyloid |
| mesh[47].qualifier_ui | Q000235 |
| mesh[47].descriptor_ui | D000682 |
| mesh[47].is_major_topic | False |
| mesh[47].qualifier_name | genetics |
| mesh[47].descriptor_name | Amyloid |
| mesh[48].qualifier_ui | Q000648 |
| mesh[48].descriptor_ui | D000682 |
| mesh[48].is_major_topic | False |
| mesh[48].qualifier_name | ultrastructure |
| mesh[48].descriptor_name | Amyloid |
| mesh[49].qualifier_ui | Q000235 |
| mesh[49].descriptor_ui | D016229 |
| mesh[49].is_major_topic | False |
| mesh[49].qualifier_name | genetics |
| mesh[49].descriptor_name | Amyloid beta-Peptides |
| type | article |
| title | Megadalton-sized Dityrosine Aggregates of α-Synuclein Retain High Degrees of Structural Disorder and Internal Dynamics |
| biblio.issue | 24 |
| biblio.volume | 432 |
| biblio.last_page | 166689 |
| biblio.first_page | 166689 |
| topics[0].id | https://openalex.org/T10086 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 0.9998999834060669 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2737 |
| topics[0].subfield.display_name | Physiology |
| topics[0].display_name | Alzheimer's disease research and treatments |
| topics[1].id | https://openalex.org/T10085 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.9998999834060669 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2728 |
| topics[1].subfield.display_name | Neurology |
| topics[1].display_name | Parkinson's Disease Mechanisms and Treatments |
| topics[2].id | https://openalex.org/T11274 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.9941999912261963 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2728 |
| topics[2].subfield.display_name | Neurology |
| topics[2].display_name | Botulinum Toxin and Related Neurological Disorders |
| is_xpac | False |
| apc_list.value | 4250 |
| apc_list.currency | USD |
| apc_list.value_usd | 4250 |
| apc_paid.value | 4250 |
| apc_paid.currency | USD |
| apc_paid.value_usd | 4250 |
| concepts[0].id | https://openalex.org/C185592680 |
| concepts[0].level | 0 |
| concepts[0].score | 0.762738823890686 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q2329 |
| concepts[0].display_name | Chemistry |
| concepts[1].id | https://openalex.org/C2777633098 |
| concepts[1].level | 2 |
| concepts[1].score | 0.5596637725830078 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q2736051 |
| concepts[1].display_name | Amyloid (mycology) |
| concepts[2].id | https://openalex.org/C2780768313 |
| concepts[2].level | 3 |
| concepts[2].score | 0.5592871904373169 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q408068 |
| concepts[2].display_name | Cytochrome |
| concepts[3].id | https://openalex.org/C12554922 |
| concepts[3].level | 1 |
| concepts[3].score | 0.5572701096534729 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q7100 |
| concepts[3].display_name | Biophysics |
| concepts[4].id | https://openalex.org/C136238340 |
| concepts[4].level | 2 |
| concepts[4].score | 0.538733184337616 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q7251455 |
| concepts[4].display_name | Protein aggregation |
| concepts[5].id | https://openalex.org/C48349386 |
| concepts[5].level | 2 |
| concepts[5].score | 0.5334674715995789 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q424361 |
| concepts[5].display_name | Reactive oxygen species |
| concepts[6].id | https://openalex.org/C29311851 |
| concepts[6].level | 3 |
| concepts[6].score | 0.49229586124420166 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q408223 |
| concepts[6].display_name | Cytochrome c |
| concepts[7].id | https://openalex.org/C166940927 |
| concepts[7].level | 3 |
| concepts[7].score | 0.4623398184776306 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q178827 |
| concepts[7].display_name | Monomer |
| concepts[8].id | https://openalex.org/C2781449126 |
| concepts[8].level | 4 |
| concepts[8].score | 0.41630157828330994 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q288591 |
| concepts[8].display_name | Alpha-synuclein |
| concepts[9].id | https://openalex.org/C2776151105 |
| concepts[9].level | 2 |
| concepts[9].score | 0.4124471843242645 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q898814 |
| concepts[9].display_name | Oxidative stress |
| concepts[10].id | https://openalex.org/C28859421 |
| concepts[10].level | 2 |
| concepts[10].score | 0.34534952044487 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q39572 |
| concepts[10].display_name | Mitochondrion |
| concepts[11].id | https://openalex.org/C55493867 |
| concepts[11].level | 1 |
| concepts[11].score | 0.33582502603530884 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q7094 |
| concepts[11].display_name | Biochemistry |
| concepts[12].id | https://openalex.org/C86803240 |
| concepts[12].level | 0 |
| concepts[12].score | 0.10697677731513977 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[12].display_name | Biology |
| concepts[13].id | https://openalex.org/C2779734285 |
| concepts[13].level | 3 |
| concepts[13].score | 0.09225958585739136 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q11085 |
| concepts[13].display_name | Parkinson's disease |
| concepts[14].id | https://openalex.org/C181199279 |
| concepts[14].level | 2 |
| concepts[14].score | 0.08889496326446533 |
| concepts[14].wikidata | https://www.wikidata.org/wiki/Q8047 |
| concepts[14].display_name | Enzyme |
| concepts[15].id | https://openalex.org/C178790620 |
| concepts[15].level | 1 |
| concepts[15].score | 0.08434832096099854 |
| concepts[15].wikidata | https://www.wikidata.org/wiki/Q11351 |
| concepts[15].display_name | Organic chemistry |
| concepts[16].id | https://openalex.org/C2779134260 |
| concepts[16].level | 2 |
| concepts[16].score | 0.0 |
| concepts[16].wikidata | https://www.wikidata.org/wiki/Q12136 |
| concepts[16].display_name | Disease |
| concepts[17].id | https://openalex.org/C71924100 |
| concepts[17].level | 0 |
| concepts[17].score | 0.0 |
| concepts[17].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[17].display_name | Medicine |
| concepts[18].id | https://openalex.org/C142724271 |
| concepts[18].level | 1 |
| concepts[18].score | 0.0 |
| concepts[18].wikidata | https://www.wikidata.org/wiki/Q7208 |
| concepts[18].display_name | Pathology |
| concepts[19].id | https://openalex.org/C521977710 |
| concepts[19].level | 2 |
| concepts[19].score | 0.0 |
| concepts[19].wikidata | https://www.wikidata.org/wiki/Q81163 |
| concepts[19].display_name | Polymer |
| concepts[20].id | https://openalex.org/C179104552 |
| concepts[20].level | 1 |
| concepts[20].score | 0.0 |
| concepts[20].wikidata | https://www.wikidata.org/wiki/Q11165 |
| concepts[20].display_name | Inorganic chemistry |
| keywords[0].id | https://openalex.org/keywords/chemistry |
| keywords[0].score | 0.762738823890686 |
| keywords[0].display_name | Chemistry |
| keywords[1].id | https://openalex.org/keywords/amyloid |
| keywords[1].score | 0.5596637725830078 |
| keywords[1].display_name | Amyloid (mycology) |
| keywords[2].id | https://openalex.org/keywords/cytochrome |
| keywords[2].score | 0.5592871904373169 |
| keywords[2].display_name | Cytochrome |
| keywords[3].id | https://openalex.org/keywords/biophysics |
| keywords[3].score | 0.5572701096534729 |
| keywords[3].display_name | Biophysics |
| keywords[4].id | https://openalex.org/keywords/protein-aggregation |
| keywords[4].score | 0.538733184337616 |
| keywords[4].display_name | Protein aggregation |
| keywords[5].id | https://openalex.org/keywords/reactive-oxygen-species |
| keywords[5].score | 0.5334674715995789 |
| keywords[5].display_name | Reactive oxygen species |
| keywords[6].id | https://openalex.org/keywords/cytochrome-c |
| keywords[6].score | 0.49229586124420166 |
| keywords[6].display_name | Cytochrome c |
| keywords[7].id | https://openalex.org/keywords/monomer |
| keywords[7].score | 0.4623398184776306 |
| keywords[7].display_name | Monomer |
| keywords[8].id | https://openalex.org/keywords/alpha-synuclein |
| keywords[8].score | 0.41630157828330994 |
| keywords[8].display_name | Alpha-synuclein |
| keywords[9].id | https://openalex.org/keywords/oxidative-stress |
| keywords[9].score | 0.4124471843242645 |
| keywords[9].display_name | Oxidative stress |
| keywords[10].id | https://openalex.org/keywords/mitochondrion |
| keywords[10].score | 0.34534952044487 |
| keywords[10].display_name | Mitochondrion |
| keywords[11].id | https://openalex.org/keywords/biochemistry |
| keywords[11].score | 0.33582502603530884 |
| keywords[11].display_name | Biochemistry |
| keywords[12].id | https://openalex.org/keywords/biology |
| keywords[12].score | 0.10697677731513977 |
| keywords[12].display_name | Biology |
| keywords[13].id | https://openalex.org/keywords/parkinsons-disease |
| keywords[13].score | 0.09225958585739136 |
| keywords[13].display_name | Parkinson's disease |
| keywords[14].id | https://openalex.org/keywords/enzyme |
| keywords[14].score | 0.08889496326446533 |
| keywords[14].display_name | Enzyme |
| keywords[15].id | https://openalex.org/keywords/organic-chemistry |
| keywords[15].score | 0.08434832096099854 |
| keywords[15].display_name | Organic chemistry |
| language | en |
| locations[0].id | doi:10.1016/j.jmb.2020.10.023 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S46058472 |
| locations[0].source.issn | 0022-2836, 1089-8638 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | 0022-2836 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | Journal of Molecular Biology |
| locations[0].source.host_organization | https://openalex.org/P4310320990 |
| locations[0].source.host_organization_name | Elsevier BV |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310320990 |
| locations[0].source.host_organization_lineage_names | Elsevier BV |
| locations[0].license | cc-by |
| locations[0].pdf_url | https://www.sciencedirect.com/science/article/pii/S0022283620305982?via%3Dihub |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Journal of Molecular Biology |
| locations[0].landing_page_url | https://doi.org/10.1016/j.jmb.2020.10.023 |
| locations[1].id | pmid:33211011 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Journal of molecular biology |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/33211011 |
| locations[2].id | pmh:oai:HAL:hal-03031719v1 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S4306402512 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | HAL (Le Centre pour la Communication Scientifique Directe) |
| locations[2].source.host_organization | https://openalex.org/I1294671590 |
| locations[2].source.host_organization_name | Centre National de la Recherche Scientifique |
| locations[2].source.host_organization_lineage | https://openalex.org/I1294671590 |
| locations[2].license | other-oa |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Journal articles |
| locations[2].license_id | https://openalex.org/licenses/other-oa |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | Journal of Molecular Biology, 2020, 432 (24), pp.166689. ⟨10.1016/j.jmb.2020.10.023⟩ |
| locations[2].landing_page_url | https://hal.science/hal-03031719 |
| locations[3].id | pmh:oai:europepmc.org:6702149 |
| locations[3].is_oa | True |
| locations[3].source.id | https://openalex.org/S4306400806 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | False |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | Europe PMC (PubMed Central) |
| locations[3].source.host_organization | https://openalex.org/I1303153112 |
| locations[3].source.host_organization_name | European Bioinformatics Institute |
| locations[3].source.host_organization_lineage | https://openalex.org/I1303153112 |
| locations[3].license | cc-by |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | Text |
| locations[3].license_id | https://openalex.org/licenses/cc-by |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | |
| locations[3].landing_page_url | http://europepmc.org/pmc/articles/PMC7779668 |
| locations[4].id | pmh:oai:pubmedcentral.nih.gov:7779668 |
| locations[4].is_oa | True |
| locations[4].source.id | https://openalex.org/S2764455111 |
| locations[4].source.issn | |
| locations[4].source.type | repository |
| locations[4].source.is_oa | False |
| locations[4].source.issn_l | |
| locations[4].source.is_core | False |
| locations[4].source.is_in_doaj | False |
| locations[4].source.display_name | PubMed Central |
| locations[4].source.host_organization | https://openalex.org/I1299303238 |
| locations[4].source.host_organization_name | National Institutes of Health |
| locations[4].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[4].license | cc-by |
| locations[4].pdf_url | |
| locations[4].version | submittedVersion |
| locations[4].raw_type | Text |
| locations[4].license_id | https://openalex.org/licenses/cc-by |
| locations[4].is_accepted | False |
| locations[4].is_published | False |
| locations[4].raw_source_name | J Mol Biol |
| locations[4].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/7779668 |
| indexed_in | crossref, pubmed |
| authorships[0].author.id | https://openalex.org/A5070565546 |
| authorships[0].author.orcid | |
| authorships[0].author.display_name | Silvia Verzini |
| authorships[0].countries | DE |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I315704651 |
| authorships[0].affiliations[0].raw_affiliation_string | Leibniz Institute of Molecular Pharmacology (FMP-Berlin), Robert-Rössle Strasse 10, 13125 Berlin, Germany |
| authorships[0].institutions[0].id | https://openalex.org/I315704651 |
| authorships[0].institutions[0].ror | https://ror.org/01n6r0e97 |
| authorships[0].institutions[0].type | government |
| authorships[0].institutions[0].lineage | https://openalex.org/I315704651 |
| authorships[0].institutions[0].country_code | DE |
| authorships[0].institutions[0].display_name | Leibniz Association |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Silvia Verzini |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Leibniz Institute of Molecular Pharmacology (FMP-Berlin), Robert-Rössle Strasse 10, 13125 Berlin, Germany |
| authorships[1].author.id | https://openalex.org/A5102376004 |
| authorships[1].author.orcid | |
| authorships[1].author.display_name | Maliha Shah |
| authorships[1].countries | DE |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I205582932 |
| authorships[1].affiliations[0].raw_affiliation_string | Neuroproteomics Laboratory, Max Delbrück Centre for Molecular Medicine (MDC-Berlin), Robert-Rössle Strasse 10, 13125 Berlin, Germany |
| authorships[1].institutions[0].id | https://openalex.org/I205582932 |
| authorships[1].institutions[0].ror | https://ror.org/04p5ggc03 |
| authorships[1].institutions[0].type | facility |
| authorships[1].institutions[0].lineage | https://openalex.org/I1305996414, https://openalex.org/I205582932 |
| authorships[1].institutions[0].country_code | DE |
| authorships[1].institutions[0].display_name | Max Delbrück Center |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Maliha Shah |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Neuroproteomics Laboratory, Max Delbrück Centre for Molecular Medicine (MDC-Berlin), Robert-Rössle Strasse 10, 13125 Berlin, Germany |
| authorships[2].author.id | https://openalex.org/A5036907339 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-3264-210X |
| authorships[2].author.display_name | François‐Xavier Theillet |
| authorships[2].countries | DE |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I315704651 |
| authorships[2].affiliations[0].raw_affiliation_string | Leibniz Institute of Molecular Pharmacology (FMP-Berlin), Robert-Rössle Strasse 10, 13125 Berlin, Germany |
| authorships[2].institutions[0].id | https://openalex.org/I315704651 |
| authorships[2].institutions[0].ror | https://ror.org/01n6r0e97 |
| authorships[2].institutions[0].type | government |
| authorships[2].institutions[0].lineage | https://openalex.org/I315704651 |
| authorships[2].institutions[0].country_code | DE |
| authorships[2].institutions[0].display_name | Leibniz Association |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Francois-Xavier Theillet |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Leibniz Institute of Molecular Pharmacology (FMP-Berlin), Robert-Rössle Strasse 10, 13125 Berlin, Germany |
| authorships[3].author.id | https://openalex.org/A5074575507 |
| authorships[3].author.orcid | https://orcid.org/0000-0002-8442-4964 |
| authorships[3].author.display_name | Adam Belsom |
| authorships[3].countries | GB |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I4210134627, https://openalex.org/I98677209 |
| authorships[3].affiliations[0].raw_affiliation_string | Wellcome Centre for Cell Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3BF, United Kingdom |
| authorships[3].institutions[0].id | https://openalex.org/I98677209 |
| authorships[3].institutions[0].ror | https://ror.org/01nrxwf90 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I98677209 |
| authorships[3].institutions[0].country_code | GB |
| authorships[3].institutions[0].display_name | University of Edinburgh |
| authorships[3].institutions[1].id | https://openalex.org/I4210134627 |
| authorships[3].institutions[1].ror | https://ror.org/03xbccz06 |
| authorships[3].institutions[1].type | facility |
| authorships[3].institutions[1].lineage | https://openalex.org/I4210134627, https://openalex.org/I87048295, https://openalex.org/I98677209 |
| authorships[3].institutions[1].country_code | GB |
| authorships[3].institutions[1].display_name | Wellcome Centre for Cell Biology |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Adam Belsom |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Wellcome Centre for Cell Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3BF, United Kingdom |
| authorships[4].author.id | https://openalex.org/A5050034567 |
| authorships[4].author.orcid | https://orcid.org/0000-0002-3485-9767 |
| authorships[4].author.display_name | Jan Bieschke |
| authorships[4].countries | DE |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I205582932 |
| authorships[4].affiliations[0].raw_affiliation_string | Neuroproteomics Laboratory, Max Delbrück Centre for Molecular Medicine (MDC-Berlin), Robert-Rössle Strasse 10, 13125 Berlin, Germany |
| authorships[4].institutions[0].id | https://openalex.org/I205582932 |
| authorships[4].institutions[0].ror | https://ror.org/04p5ggc03 |
| authorships[4].institutions[0].type | facility |
| authorships[4].institutions[0].lineage | https://openalex.org/I1305996414, https://openalex.org/I205582932 |
| authorships[4].institutions[0].country_code | DE |
| authorships[4].institutions[0].display_name | Max Delbrück Center |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Jan Bieschke |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Neuroproteomics Laboratory, Max Delbrück Centre for Molecular Medicine (MDC-Berlin), Robert-Rössle Strasse 10, 13125 Berlin, Germany |
| authorships[5].author.id | https://openalex.org/A5014950513 |
| authorships[5].author.orcid | https://orcid.org/0000-0001-8072-1630 |
| authorships[5].author.display_name | Erich E. Wanker |
| authorships[5].countries | DE |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I205582932 |
| authorships[5].affiliations[0].raw_affiliation_string | Neuroproteomics Laboratory, Max Delbrück Centre for Molecular Medicine (MDC-Berlin), Robert-Rössle Strasse 10, 13125 Berlin, Germany |
| authorships[5].institutions[0].id | https://openalex.org/I205582932 |
| authorships[5].institutions[0].ror | https://ror.org/04p5ggc03 |
| authorships[5].institutions[0].type | facility |
| authorships[5].institutions[0].lineage | https://openalex.org/I1305996414, https://openalex.org/I205582932 |
| authorships[5].institutions[0].country_code | DE |
| authorships[5].institutions[0].display_name | Max Delbrück Center |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Erich E. Wanker |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Neuroproteomics Laboratory, Max Delbrück Centre for Molecular Medicine (MDC-Berlin), Robert-Rössle Strasse 10, 13125 Berlin, Germany |
| authorships[6].author.id | https://openalex.org/A5076844877 |
| authorships[6].author.orcid | https://orcid.org/0000-0001-5999-1310 |
| authorships[6].author.display_name | Juri Rappsilber |
| authorships[6].countries | GB |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I4210134627, https://openalex.org/I98677209 |
| authorships[6].affiliations[0].raw_affiliation_string | Wellcome Centre for Cell Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3BF, United Kingdom |
| authorships[6].institutions[0].id | https://openalex.org/I98677209 |
| authorships[6].institutions[0].ror | https://ror.org/01nrxwf90 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I98677209 |
| authorships[6].institutions[0].country_code | GB |
| authorships[6].institutions[0].display_name | University of Edinburgh |
| authorships[6].institutions[1].id | https://openalex.org/I4210134627 |
| authorships[6].institutions[1].ror | https://ror.org/03xbccz06 |
| authorships[6].institutions[1].type | facility |
| authorships[6].institutions[1].lineage | https://openalex.org/I4210134627, https://openalex.org/I87048295, https://openalex.org/I98677209 |
| authorships[6].institutions[1].country_code | GB |
| authorships[6].institutions[1].display_name | Wellcome Centre for Cell Biology |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Juri Rappsilber |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Wellcome Centre for Cell Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3BF, United Kingdom |
| authorships[7].author.id | https://openalex.org/A5081514680 |
| authorships[7].author.orcid | https://orcid.org/0000-0003-2374-0864 |
| authorships[7].author.display_name | Andrés Binolfi |
| authorships[7].countries | DE |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I315704651 |
| authorships[7].affiliations[0].raw_affiliation_string | Leibniz Institute of Molecular Pharmacology (FMP-Berlin), Robert-Rössle Strasse 10, 13125 Berlin, Germany |
| authorships[7].institutions[0].id | https://openalex.org/I315704651 |
| authorships[7].institutions[0].ror | https://ror.org/01n6r0e97 |
| authorships[7].institutions[0].type | government |
| authorships[7].institutions[0].lineage | https://openalex.org/I315704651 |
| authorships[7].institutions[0].country_code | DE |
| authorships[7].institutions[0].display_name | Leibniz Association |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Andres Binolfi |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Leibniz Institute of Molecular Pharmacology (FMP-Berlin), Robert-Rössle Strasse 10, 13125 Berlin, Germany |
| authorships[8].author.id | https://openalex.org/A5047530888 |
| authorships[8].author.orcid | https://orcid.org/0000-0002-2590-5899 |
| authorships[8].author.display_name | Philipp Selenko |
| authorships[8].countries | DE |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I315704651 |
| authorships[8].affiliations[0].raw_affiliation_string | Leibniz Institute of Molecular Pharmacology (FMP-Berlin), Robert-Rössle Strasse 10, 13125 Berlin, Germany |
| authorships[8].institutions[0].id | https://openalex.org/I315704651 |
| authorships[8].institutions[0].ror | https://ror.org/01n6r0e97 |
| authorships[8].institutions[0].type | government |
| authorships[8].institutions[0].lineage | https://openalex.org/I315704651 |
| authorships[8].institutions[0].country_code | DE |
| authorships[8].institutions[0].display_name | Leibniz Association |
| authorships[8].author_position | last |
| authorships[8].raw_author_name | Philipp Selenko |
| authorships[8].is_corresponding | True |
| authorships[8].raw_affiliation_strings | Leibniz Institute of Molecular Pharmacology (FMP-Berlin), Robert-Rössle Strasse 10, 13125 Berlin, Germany |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.sciencedirect.com/science/article/pii/S0022283620305982?via%3Dihub |
| open_access.oa_status | hybrid |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Megadalton-sized Dityrosine Aggregates of α-Synuclein Retain High Degrees of Structural Disorder and Internal Dynamics |
| has_fulltext | True |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10086 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 0.9998999834060669 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2737 |
| primary_topic.subfield.display_name | Physiology |
| primary_topic.display_name | Alzheimer's disease research and treatments |
| related_works | https://openalex.org/W1990495513, https://openalex.org/W2159717327, https://openalex.org/W2087418933, https://openalex.org/W285885149, https://openalex.org/W131467418, https://openalex.org/W2062101022, https://openalex.org/W2009066363, https://openalex.org/W1964851241, https://openalex.org/W2062071602, https://openalex.org/W2952327480 |
| cited_by_count | 6 |
| counts_by_year[0].year | 2022 |
| counts_by_year[0].cited_by_count | 4 |
| counts_by_year[1].year | 2021 |
| counts_by_year[1].cited_by_count | 1 |
| counts_by_year[2].year | 2020 |
| counts_by_year[2].cited_by_count | 1 |
| locations_count | 5 |
| best_oa_location.id | doi:10.1016/j.jmb.2020.10.023 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S46058472 |
| best_oa_location.source.issn | 0022-2836, 1089-8638 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | 0022-2836 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | Journal of Molecular Biology |
| best_oa_location.source.host_organization | https://openalex.org/P4310320990 |
| best_oa_location.source.host_organization_name | Elsevier BV |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310320990 |
| best_oa_location.source.host_organization_lineage_names | Elsevier BV |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | https://www.sciencedirect.com/science/article/pii/S0022283620305982?via%3Dihub |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Journal of Molecular Biology |
| best_oa_location.landing_page_url | https://doi.org/10.1016/j.jmb.2020.10.023 |
| primary_location.id | doi:10.1016/j.jmb.2020.10.023 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S46058472 |
| primary_location.source.issn | 0022-2836, 1089-8638 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | 0022-2836 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | Journal of Molecular Biology |
| primary_location.source.host_organization | https://openalex.org/P4310320990 |
| primary_location.source.host_organization_name | Elsevier BV |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310320990 |
| primary_location.source.host_organization_lineage_names | Elsevier BV |
| primary_location.license | cc-by |
| primary_location.pdf_url | https://www.sciencedirect.com/science/article/pii/S0022283620305982?via%3Dihub |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Journal of Molecular Biology |
| primary_location.landing_page_url | https://doi.org/10.1016/j.jmb.2020.10.023 |
| publication_date | 2020-10-22 |
| publication_year | 2020 |
| referenced_works | https://openalex.org/W2050786534, https://openalex.org/W2573367782, https://openalex.org/W2948657684, https://openalex.org/W3008786370, https://openalex.org/W3019544891, https://openalex.org/W2994123659, https://openalex.org/W3005252823, https://openalex.org/W2936867781, https://openalex.org/W3027900078, https://openalex.org/W2807663565, https://openalex.org/W2791425412, https://openalex.org/W2805954533, https://openalex.org/W2901562883, https://openalex.org/W2912581779, https://openalex.org/W2954929323, https://openalex.org/W2992154881, https://openalex.org/W2953014442, https://openalex.org/W2903418495, https://openalex.org/W3020713084, https://openalex.org/W2980622391, https://openalex.org/W2762968408, https://openalex.org/W2107434243, https://openalex.org/W2557097191, https://openalex.org/W2567332350, https://openalex.org/W2008964882, https://openalex.org/W2075692785, https://openalex.org/W1976841598, https://openalex.org/W2053342879, https://openalex.org/W2254889442, https://openalex.org/W2608017621, https://openalex.org/W2755777121, https://openalex.org/W2909998927, https://openalex.org/W2025958871, https://openalex.org/W2073058641, https://openalex.org/W2253997490, https://openalex.org/W2253387945, https://openalex.org/W2098163450, https://openalex.org/W955725593, https://openalex.org/W2121937669, https://openalex.org/W2138375082, https://openalex.org/W2038286309, https://openalex.org/W2765802263, https://openalex.org/W2023245921, https://openalex.org/W2954385672, https://openalex.org/W1518948023, https://openalex.org/W2093861673, https://openalex.org/W2775514330, https://openalex.org/W3008583555, https://openalex.org/W3031912651, https://openalex.org/W2124819757, https://openalex.org/W1982467499, https://openalex.org/W2161639623, https://openalex.org/W2150747560, https://openalex.org/W2865327222, https://openalex.org/W2890944761, https://openalex.org/W1542222030, https://openalex.org/W2045489211, https://openalex.org/W2335096951, https://openalex.org/W2310305711, https://openalex.org/W2002439504, https://openalex.org/W2030241259, https://openalex.org/W1990473626, https://openalex.org/W6757808752, https://openalex.org/W1980704317, https://openalex.org/W2785199982, https://openalex.org/W2906543169 |
| referenced_works_count | 66 |
| abstract_inverted_index.a | 66 |
| abstract_inverted_index.In | 78 |
| abstract_inverted_index.We | 100, 152 |
| abstract_inverted_index.by | 96, 162 |
| abstract_inverted_index.c, | 65, 148 |
| abstract_inverted_index.in | 11, 56, 124, 126, 130, 165 |
| abstract_inverted_index.is | 27, 30, 70 |
| abstract_inverted_index.of | 2, 15, 36, 48, 52, 59, 89, 114, 133, 140, 193, 205 |
| abstract_inverted_index.on | 22 |
| abstract_inverted_index.to | 80, 201 |
| abstract_inverted_index.we | 41 |
| abstract_inverted_index.NMR | 98 |
| abstract_inverted_index.Our | 179 |
| abstract_inverted_index.and | 45, 63, 119, 129, 169 |
| abstract_inverted_index.are | 8, 149, 172 |
| abstract_inverted_index.c's | 188 |
| abstract_inverted_index.its | 166 |
| abstract_inverted_index.may | 199 |
| abstract_inverted_index.the | 3, 33, 43, 57, 191, 202 |
| abstract_inverted_index.Lewy | 12, 206 |
| abstract_inverted_index.body | 13, 207 |
| abstract_inverted_index.cell | 135 |
| abstract_inverted_index.find | 101 |
| abstract_inverted_index.form | 55, 123, 168 |
| abstract_inverted_index.free | 141 |
| abstract_inverted_index.from | 72 |
| abstract_inverted_index.high | 87, 195 |
| abstract_inverted_index.into | 190 |
| abstract_inverted_index.only | 109 |
| abstract_inverted_index.rate | 150 |
| abstract_inverted_index.than | 146 |
| abstract_inverted_index.that | 54, 69, 102, 155, 170, 182, 198 |
| abstract_inverted_index.they | 171 |
| abstract_inverted_index.Here, | 40 |
| abstract_inverted_index.While | 19 |
| abstract_inverted_index.about | 32 |
| abstract_inverted_index.basic | 176 |
| abstract_inverted_index.found | 10 |
| abstract_inverted_index.human | 4 |
| abstract_inverted_index.known | 31 |
| abstract_inverted_index.large | 112 |
| abstract_inverted_index.their | 94 |
| abstract_inverted_index.these | 84 |
| abstract_inverted_index.vitro | 127 |
| abstract_inverted_index.where | 137 |
| abstract_inverted_index.which | 92 |
| abstract_inverted_index.αSyn | 24, 53, 107, 164, 184 |
| abstract_inverted_index.during | 74 |
| abstract_inverted_index.little | 29 |
| abstract_inverted_index.oxygen | 61, 143 |
| abstract_inverted_index.rather | 145 |
| abstract_inverted_index.remain | 117 |
| abstract_inverted_index.retain | 86 |
| abstract_inverted_index.(αSyn) | 7 |
| abstract_inverted_index.adducts | 51, 157 |
| abstract_inverted_index.amounts | 139 |
| abstract_inverted_index.amyloid | 25, 160 |
| abstract_inverted_index.analyze | 42 |
| abstract_inverted_index.complex | 131 |
| abstract_inverted_index.crowded | 125 |
| abstract_inverted_index.degrees | 88 |
| abstract_inverted_index.despite | 174 |
| abstract_inverted_index.disease | 17 |
| abstract_inverted_index.dynamic | 46 |
| abstract_inverted_index.enables | 93 |
| abstract_inverted_index.fibrils | 26 |
| abstract_inverted_index.further | 153 |
| abstract_inverted_index.inhibit | 158 |
| abstract_inverted_index.locally | 110 |
| abstract_inverted_index.motions | 108 |
| abstract_inverted_index.protein | 5 |
| abstract_inverted_index.results | 180 |
| abstract_inverted_index.species | 62 |
| abstract_inverted_index.stress. | 77 |
| abstract_inverted_index.suggest | 181 |
| abstract_inverted_index.whereas | 111 |
| abstract_inverted_index.activity | 189 |
| abstract_inverted_index.contrast | 79 |
| abstract_inverted_index.cross-β | 82 |
| abstract_inverted_index.flexible | 118 |
| abstract_inverted_index.internal | 90 |
| abstract_inverted_index.lysates, | 136 |
| abstract_inverted_index.presence | 58 |
| abstract_inverted_index.reactive | 60, 142 |
| abstract_inverted_index.relative | 138 |
| abstract_inverted_index.released | 71 |
| abstract_inverted_index.restrict | 106 |
| abstract_inverted_index.segments | 113 |
| abstract_inverted_index.species, | 144 |
| abstract_inverted_index.amyloids, | 83 |
| abstract_inverted_index.canonical | 81 |
| abstract_inverted_index.classical | 23, 159 |
| abstract_inverted_index.deposits. | 208 |
| abstract_inverted_index.diversity | 204 |
| abstract_inverted_index.dynamics, | 91 |
| abstract_inverted_index.establish | 154 |
| abstract_inverted_index.formation | 161, 192 |
| abstract_inverted_index.limiting. | 151 |
| abstract_inverted_index.mammalian | 134 |
| abstract_inverted_index.molecules | 116 |
| abstract_inverted_index.monomeric | 167 |
| abstract_inverted_index.oxidative | 76, 183 |
| abstract_inverted_index.patients. | 18 |
| abstract_inverted_index.retaining | 175 |
| abstract_inverted_index.scavenges | 186 |
| abstract_inverted_index.solutions | 128 |
| abstract_inverted_index.sustained | 75 |
| abstract_inverted_index.abundantly | 9 |
| abstract_inverted_index.aggregates | 1, 85, 122 |
| abstract_inverted_index.amorphous, | 194 |
| abstract_inverted_index.available, | 28 |
| abstract_inverted_index.contribute | 200 |
| abstract_inverted_index.crosslinks | 105 |
| abstract_inverted_index.cytochrome | 64, 147, 187 |
| abstract_inverted_index.dityrosine | 50, 104, 156 |
| abstract_inverted_index.inclusions | 14 |
| abstract_inverted_index.peroxidase | 68 |
| abstract_inverted_index.properties | 35, 47 |
| abstract_inverted_index.structural | 20, 44, 203 |
| abstract_inverted_index.structures | 197 |
| abstract_inverted_index.Parkinson's | 16 |
| abstract_inverted_index.aggregates. | 39 |
| abstract_inverted_index.aggregation | 185 |
| abstract_inverted_index.disordered. | 120 |
| abstract_inverted_index.information | 21 |
| abstract_inverted_index.maintaining | 163 |
| abstract_inverted_index.properties. | 178 |
| abstract_inverted_index.concatenated | 115 |
| abstract_inverted_index.environments | 132 |
| abstract_inverted_index.mitochondria | 73 |
| abstract_inverted_index.proapoptotic | 67 |
| abstract_inverted_index.α-synuclein | 6 |
| abstract_inverted_index.Heterogeneous | 0 |
| abstract_inverted_index.non-canonical | 38 |
| abstract_inverted_index.non-cytotoxic | 173 |
| abstract_inverted_index.spectroscopy. | 99 |
| abstract_inverted_index.conformational | 34 |
| abstract_inverted_index.intermolecular | 103 |
| abstract_inverted_index.solution-state | 97 |
| abstract_inverted_index.characterization | 95 |
| abstract_inverted_index.megadalton-sized | 49 |
| abstract_inverted_index.membrane-binding | 177 |
| abstract_inverted_index.molecular-weight | 196 |
| abstract_inverted_index.Indistinguishable | 121 |
| abstract_inverted_index.disease-relevant, | 37 |
| cited_by_percentile_year.max | 97 |
| cited_by_percentile_year.min | 89 |
| corresponding_author_ids | https://openalex.org/A5047530888 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 9 |
| corresponding_institution_ids | https://openalex.org/I315704651 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/15 |
| sustainable_development_goals[0].score | 0.5699999928474426 |
| sustainable_development_goals[0].display_name | Life in Land |
| citation_normalized_percentile.value | 0.71508104 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |