MEKK2 inhibits activation of MAP kinases in Arabidopsis Article Swipe
Yukino Nitta
,
Yichun Qiu
,
Hoda Yaghmaiean
,
Qian Zhang
,
Jianhua Huang
,
Keith L. Adams
,
Yuelin Zhang
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1111/tpj.14763
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1111/tpj.14763
SUMMARY The Arabidopsis MEKK1‐MKK1/MKK2‐MPK4 kinase cascade is monitored by the nucleotide‐binding leucine‐rich‐repeat immune receptor SUMM2. Disruption of this kinase cascade leads to activation of SUMM2‐mediated immune responses. MEKK2, a close paralog of MEKK1, is required for defense responses mediated by SUMM2, the molecular mechanism of which is unclear. In this study, we showed that MEKK2 serves as a negative regulator of MPK4. It binds to MPK4 to directly inhibit its phosphorylation by upstream MKKs. Activation of SUMM2‐mediated defense responses induces the expression of MEKK2 , which in turn blocks MPK4 phosphorylation to further amplify immune responses mediated by SUMM2. Intriguingly, MEKK2 locates in a tandem repeat consisting of MEKK1 , MEKK2 and MEKK3 , which was generated from a recent gene duplication event, suggesting that MEKK2 evolved from a MAPKKK to become a negative regulator of MAP kinases.
Related Topics
Concepts
Arabidopsis
Biology
Kinase
Arabidopsis thaliana
MAP kinase kinase kinase
Cell biology
Phosphorylation
Regulator
Protein kinase A
Genetics
Gene
Mutant
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1111/tpj.14763
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/tpj.14763
- OA Status
- bronze
- Cited By
- 20
- References
- 35
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3014321102
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3014321102Canonical identifier for this work in OpenAlex
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https://doi.org/10.1111/tpj.14763Digital Object Identifier
- Title
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MEKK2 inhibits activation of MAP kinases in ArabidopsisWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2020Year of publication
- Publication date
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2020-04-08Full publication date if available
- Authors
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Yukino Nitta, Yichun Qiu, Hoda Yaghmaiean, Qian Zhang, Jianhua Huang, Keith L. Adams, Yuelin ZhangList of authors in order
- Landing page
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https://doi.org/10.1111/tpj.14763Publisher landing page
- PDF URL
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/tpj.14763Direct link to full text PDF
- Open access
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YesWhether a free full text is available
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bronzeOpen access status per OpenAlex
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/tpj.14763Direct OA link when available
- Concepts
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Arabidopsis, Biology, Kinase, Arabidopsis thaliana, MAP kinase kinase kinase, Cell biology, Phosphorylation, Regulator, Protein kinase A, Genetics, Gene, MutantTop concepts (fields/topics) attached by OpenAlex
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20Total citation count in OpenAlex
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2025: 2, 2024: 4, 2023: 4, 2022: 5, 2021: 3Per-year citation counts (last 5 years)
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35Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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