Membrane oxygenator longevity was higher in argatroban‐treated patients undergoing vvECMO
Article Swipe
Loredana Menninger
,
Andreas Körner
,
Valbona Mirakaj
,
Ka‐Lin Heck‐Swain
,
Helene A. Haeberle
,
Karina Althaus
,
Michael R. Baumgaertner
,
Walter Jost
,
Christian Schlensak
,
Peter Rosenberger
,
Michael Koeppen
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1111/eci.13963
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1111/eci.13963
Background In severe acute respiratory distress syndrome (ARDS), venovenous extracorporeal membrane oxygenation (vvECMO) can be a lifesaver. However, anticoagulation therapy is mandatory because the nonendothelial extracorporeal surface increases the risk of thromboembolic problems. Heparin is still the most common anticoagulant, but argatroban could be an alternative. This work investigates whether argatroban offers a therapeutic advantage over heparin during vvECMO. Methods We performed a retrospective cohort study of patients who underwent vvECMO for severe ARDS and received heparin or argatroban as anticoagulation therapy. Demographic variables, intensive care unit (ICU) treatment and outcome parameters were evaluated. The primary outcome parameter was the operating time of the membrane oxygenator normalized to the duration of vvECMO treatment. Secondary outcome parameters were transfusion requirements normalized to the duration of vvECMO therapy. Results Fifty seven patients from January 2019 to February 2021 underwent vvECMO and were included in this study. Thirty three patients received heparin and 24 patients argatroban as anticoagulatory therapy. The groups did not differ in demographics, ICU scoring systems, or comorbidities. Platelet counts and partial prothrombin time did not differ between the two groups during the first 6 days of vvECMO. The argatroban group had lower requirements for red blood cells, platelets and fresh frozen plasma. The mean runtime of the individual membrane oxygenator increased from 12.3 days (heparin group) to 16.6 days in the argatroban group. Conclusions Our findings suggest that argatroban can be considered as anticoagulant during vvECMO.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1111/eci.13963
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/eci.13963
- OA Status
- hybrid
- Cited By
- 6
- References
- 26
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4318671299
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4318671299Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1111/eci.13963Digital Object Identifier
- Title
-
Membrane oxygenator longevity was higher in argatroban‐treated patients undergoing
vvECMO Work title - Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-01-31Full publication date if available
- Authors
-
Loredana Menninger, Andreas Körner, Valbona Mirakaj, Ka‐Lin Heck‐Swain, Helene A. Haeberle, Karina Althaus, Michael R. Baumgaertner, Walter Jost, Christian Schlensak, Peter Rosenberger, Michael KoeppenList of authors in order
- Landing page
-
https://doi.org/10.1111/eci.13963Publisher landing page
- PDF URL
-
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/eci.13963Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
-
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/eci.13963Direct OA link when available
- Concepts
-
Argatroban, Medicine, Membrane oxygenator, Extracorporeal membrane oxygenation, Heparin, Heparin-induced thrombocytopenia, ARDS, Anesthesia, Oxygenator, Anticoagulant, Retrospective cohort study, Intensive care unit, Surgery, Internal medicine, Platelet, Cardiopulmonary bypass, Lung, ThrombinTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
6Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 2, 2024: 4Per-year citation counts (last 5 years)
- References (count)
-
26Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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