Mendelian randomization analysis using GWAS and eQTL data to investigate the relationship between chronotype and neuropsychiatric disorders and their molecular basis
Article Swipe
Shane Crinion
,
Cathy Wyse
,
Gary Donohoe
,
Lorna M. Lopez
,
Derek W. Morris
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1002/ajmg.b.32980
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1002/ajmg.b.32980
Chronotype is a proxy sleep measure that has been associated with neuropsychiatric disorders. By investigating how chronotype influences risk for neuropsychiatric disorders and vice versa, we may identify modifiable risk factors for each phenotype. Here we used Mendelian randomization (MR), to explore causal effects by (1) studying the causal relationships between neuropsychiatric disorders and chronotype and (2) characterizing the genetic components of these phenotypes. Firstly, we investigated if a causal role exists between five neuropsychiatric disorders and chronotype using the largest genome‐wide association studies (GWAS) available. Secondly, we integrated data from expression quantitative trait loci (eQTLs) to investigate the role of gene expression alterations on these phenotypes. Evening chronotype was causal for increased risk of schizophrenia and autism spectrum disorder and schizophrenia was causal for a tendency toward evening chronotype. We identified 12 eQTLs where gene expression changes in brain or blood were causal for one of the phenotypes, including two eQTLs for SNX19 in hippocampus and hypothalamus that were causal for schizophrenia. These findings provide important evidence for the complex, bidirectional relationship that exists between a sleep‐based phenotype and neuropsychiatric disorders, and use gene expression data to identify causal roles for genes at associated loci.
Related Topics
Concepts
Chronotype
Mendelian randomization
Genome-wide association study
Schizophrenia (object-oriented programming)
Expression quantitative trait loci
Psychology
Genetics
Genetic association
Biology
Single-nucleotide polymorphism
Psychiatry
Gene
Neuroscience
Genotype
Circadian rhythm
Genetic variants
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/ajmg.b.32980
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ajmg.b.32980
- OA Status
- hybrid
- Cited By
- 3
- References
- 49
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4393313063
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4393313063Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1002/ajmg.b.32980Digital Object Identifier
- Title
-
Mendelian randomization analysis using
GWAS andeQTL data to investigate the relationship between chronotype and neuropsychiatric disorders and their molecular basisWork title - Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-03-29Full publication date if available
- Authors
-
Shane Crinion, Cathy Wyse, Gary Donohoe, Lorna M. Lopez, Derek W. MorrisList of authors in order
- Landing page
-
https://doi.org/10.1002/ajmg.b.32980Publisher landing page
- PDF URL
-
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ajmg.b.32980Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
-
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ajmg.b.32980Direct OA link when available
- Concepts
-
Chronotype, Mendelian randomization, Genome-wide association study, Schizophrenia (object-oriented programming), Expression quantitative trait loci, Psychology, Genetics, Genetic association, Biology, Single-nucleotide polymorphism, Psychiatry, Gene, Neuroscience, Genotype, Circadian rhythm, Genetic variantsTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
3Total citation count in OpenAlex
- Citations by year (recent)
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2025: 1, 2024: 2Per-year citation counts (last 5 years)
- References (count)
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49Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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