American Journal of Medical Genetics Part B Neuropsychiatric Genetics • Vol 195 • No 7
Mendelian randomization analysis using <scp>GWAS</scp> and <scp>eQTL</scp> data to investigate the relationship between chronotype and neuropsychiatric disorders and their molecular basis
March 2024 • Shane Crinion, Cathy Wyse, Gary Donohoe, Lorna M. Lopez, Derek W. Morris
Abstract Chronotype is a proxy sleep measure that has been associated with neuropsychiatric disorders. By investigating how chronotype influences risk for neuropsychiatric disorders and vice versa, we may identify modifiable risk factors for each phenotype. Here we used Mendelian randomization (MR), to explore causal effects by (1) studying the causal relationships between neuropsychiatric disorders and chronotype and (2) characterizing the genetic components of these phenotypes. Firstly, we investigated if a caus…