Meningitis Caused by the Live Varicella Vaccine Virus: Metagenomic Next Generation Sequencing, Immunology Exome Sequencing and Cytokine Multiplex Profiling Article Swipe
Prashanth Ramachandran
,
Michael R. Wilson
,
Gaud Catho
,
Géraldine Blanchard‐Rohner
,
Nicoline Schiess
,
Randall J. Cohrs
,
David Boutolleau
,
Sonia Burrel
,
Tetsushi Yoshikawa
,
Anne E. Wapniarski
,
Ethan H. Heusel
,
John E. Carpenter
,
Wallen Jackson
,
Bradley Ford
,
Charles Grose
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3390/v13112286
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3390/v13112286
Varicella vaccine meningitis is an uncommon delayed adverse event of vaccination. Varicella vaccine meningitis has been diagnosed in 12 children, of whom 3 were immunocompromised. We now report two additional cases of vaccine meningitis in twice-immunized immunocompetent children and we perform further testing on a prior third case. We used three methods to diagnose or investigate cases of varicella vaccine meningitis, none of which have been used previously on this disease. These include metagenomic next-generation sequencing and cytokine multiplex profiling of cerebrospinal fluid and immunology exome analysis of white blood cells. In one new case, the diagnosis was confirmed by metagenomic next-generation sequencing of cerebrospinal fluid. Both varicella vaccine virus and human herpesvirus 7 DNA were detected. We performed cytokine multiplex profiling on the cerebrospinal fluid of two cases and found ten elevated biomarkers: interferon gamma, interleukins IL-1RA, IL-6, IL-8, IL-10, IL-17F, chemokines CXCL-9, CXCL-10, CCL-2, and G-CSF. In a second new case, we performed immunology exome sequencing on a panel of 356 genes, but no errors were found. After a review of all 14 cases, we concluded that (i) there is no common explanation for this adverse event, but (ii) ingestion of an oral corticosteroid burst 3–4 weeks before onset of vaccine meningitis may be a risk factor in some cases.
Related Topics
Concepts
Medicine
Multiplex
Immunology
Exome sequencing
Meningitis
Virology
Varicella zoster virus
Vaccination
Viral meningitis
Virus
Biology
Bioinformatics
Gene
Bacterial meningitis
Pediatrics
Genetics
Mutation
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/v13112286
- https://www.mdpi.com/1999-4915/13/11/2286/pdf?version=1637040342
- OA Status
- gold
- Cited By
- 38
- References
- 61
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3214218625
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3214218625Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/v13112286Digital Object Identifier
- Title
-
Meningitis Caused by the Live Varicella Vaccine Virus: Metagenomic Next Generation Sequencing, Immunology Exome Sequencing and Cytokine Multiplex ProfilingWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-11-16Full publication date if available
- Authors
-
Prashanth Ramachandran, Michael R. Wilson, Gaud Catho, Géraldine Blanchard‐Rohner, Nicoline Schiess, Randall J. Cohrs, David Boutolleau, Sonia Burrel, Tetsushi Yoshikawa, Anne E. Wapniarski, Ethan H. Heusel, John E. Carpenter, Wallen Jackson, Bradley Ford, Charles GroseList of authors in order
- Landing page
-
https://doi.org/10.3390/v13112286Publisher landing page
- PDF URL
-
https://www.mdpi.com/1999-4915/13/11/2286/pdf?version=1637040342Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/1999-4915/13/11/2286/pdf?version=1637040342Direct OA link when available
- Concepts
-
Medicine, Multiplex, Immunology, Exome sequencing, Meningitis, Virology, Varicella zoster virus, Vaccination, Viral meningitis, Virus, Biology, Bioinformatics, Gene, Bacterial meningitis, Pediatrics, Genetics, MutationTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
38Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 9, 2024: 6, 2023: 15, 2022: 8Per-year citation counts (last 5 years)
- References (count)
-
61Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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