Meningococcal vaccination in adolescents and adults induces bactericidal activity against hyperinvasive complement-resistant meningococcal isolates Article Swipe
Milou Ohm
,
Janine Wolf
,
Debbie M. van Rooijen
,
Linda J. Visser
,
Willem R. Miellet
,
Rob Mariman
,
Krzysztof Trzciński
,
Anne‐Marie Buisman
,
Fiona van der Klis
,
Guy A. M. Berbers
,
Mirjam J. Knol
,
Nina M. van Sorge
,
Gerco den Hartog
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1101/2022.05.20.22275303
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1101/2022.05.20.22275303
Background Complement-mediated killing is critical in the defense against meningococci. During a recent outbreak of invasive meningococcal serogroup W disease (IMD-W) in the Netherlands, the predominant isolates belonged to clonal complex (cc) 11, which may suggest a role for cc11-assocated traits in complement resistance. We investigated complement resistance of invasive and carriage meningococcal isolates of different serogroups and lineages. In addition, we investigated whether vaccine-induced antibodies can overcome resistance to complement-mediated killing. Methods We analyzed IMD isolates (n=56) and carriage isolates (n=19) of different serogroups and clonal lineages in the serum bactericidal antibody (SBA) assay using pooled serum from unvaccinated and vaccinated individuals. Furthermore, we determined meningococcal serogroup W geometric mean titers (GMTs) and protection levels with the routinely-used non-cc11 isolate and hyperinvasive cc11 isolates using individual serum samples from adolescents and adults 5 years postvaccination. Results The hyperinvasive IMD isolates showed high variation in their resistance to complement-mediated killing when pooled serum from unvaccinated individuals was used (median 96, range 2-1,536). When pooled sera from vaccinated individuals was used, all isolates were killed. The minimum spanning tree revealed moderate clustering of serogroup and cc, while complement resistance did not. While a significantly lower GMT was observed against cc11 meningococcal serogroup W (MenW) compared to a non-cc11 MenW isolate in vaccinated adults but not in adolescents, we found no differences in the proportion protected between these isolates. Conclusions These data show that vaccine-induced antibodies are effectively inducing complement-mediated killing of complement-resistant hyperinvasive and carriage meningococcal isolates. Short summary Meningococcal isolates of hyperinvasive lineages are resistant to complement-mediated killing but vaccine-induced antibodies effectively kill these invasive isolates.
Related Topics
Concepts
Carriage
Vaccination
Meningococcal disease
Titer
Biology
Microbiology
Virology
Antibody
Meningococcal vaccine
Outbreak
Neisseria meningitidis
Immunology
Medicine
Immunization
Bacteria
Genetics
Pathology
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2022.05.20.22275303
- https://www.medrxiv.org/content/medrxiv/early/2022/06/01/2022.05.20.22275303.full.pdf
- OA Status
- green
- References
- 37
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4281286374
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4281286374Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1101/2022.05.20.22275303Digital Object Identifier
- Title
-
Meningococcal vaccination in adolescents and adults induces bactericidal activity against hyperinvasive complement-resistant meningococcal isolatesWork title
- Type
-
preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-05-23Full publication date if available
- Authors
-
Milou Ohm, Janine Wolf, Debbie M. van Rooijen, Linda J. Visser, Willem R. Miellet, Rob Mariman, Krzysztof Trzciński, Anne‐Marie Buisman, Fiona van der Klis, Guy A. M. Berbers, Mirjam J. Knol, Nina M. van Sorge, Gerco den HartogList of authors in order
- Landing page
-
https://doi.org/10.1101/2022.05.20.22275303Publisher landing page
- PDF URL
-
https://www.medrxiv.org/content/medrxiv/early/2022/06/01/2022.05.20.22275303.full.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
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https://www.medrxiv.org/content/medrxiv/early/2022/06/01/2022.05.20.22275303.full.pdfDirect OA link when available
- Concepts
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Carriage, Vaccination, Meningococcal disease, Titer, Biology, Microbiology, Virology, Antibody, Meningococcal vaccine, Outbreak, Neisseria meningitidis, Immunology, Medicine, Immunization, Bacteria, Genetics, PathologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
- References (count)
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37Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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