Mesoporous silica nanoparticles functionalized with folic acid/methionine for active targeted delivery of docetaxel Article Swipe

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Pegah Khosraviyan , Mehdi Shafiee Ardestani , Mehdi Khoobi , Seyed Nasser Ostad , Farid Abedin Dorkoosh , Hamid Akbari Javar , Massoud Amanlou ·

YOU? · · 2016 · Open Access · · DOI: https://doi.org/10.2147/ott.s113815

Mesoporous silica nanoparticles (MSNs) are known as carriers with high loading capacity and large functionalizable surface area for target-directed delivery. In this study, a series of docetaxel-loaded folic acid- or methionine-functionalized mesoporous silica nanoparticles (DTX/MSN-FA or DTX/MSN-Met) with large pores and amine groups at inner pore surface properties were prepared. The results showed that the MSNs were successfully synthesized, having good pay load and pH-sensitive drug release kinetics. The cellular investigation on MCF-7 cells showed better performance of cytotoxicity and cell apoptosis and an increase in cellular uptake of targeted nanoparticles. In vivo fluorescent imaging on healthy BALB/c mice proved that bare MSN-NH₂ are mostly accumulated in the liver but MSN-FA or MSN-Met are more concentrated in the kidney. Importantly, ex vivo fluorescent images of tumor-induced BALB/c mice organs revealed the ability of MSN-FA to reach the tumor tissues. In conclusion, DTX/MSNs exhibited a good anticancer activity and enhanced the possibility of targeted drug delivery for breast cancer.

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Docetaxel Mesoporous silica Folate receptor Nanoparticle Chemistry In vivo Drug delivery Mesoporous material Folic acid Cytotoxicity Biophysics Pharmacology Cancer research Nuclear chemistry Nanotechnology Cancer cell Biochemistry In vitro Cancer Materials science Medicine Organic chemistry Catalysis Internal medicine Biology Biotechnology

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Type: article
Language: en
Landing Page: https://doi.org/10.2147/ott.s113815
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OA Status: gold
Cited By: 111
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DOI: https://doi.org/10.2147/ott.s113815

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Title: Mesoporous silica nanoparticles functionalized with folic acid/methionine for active targeted delivery of docetaxel

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Language: en

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Publication year: 2016

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Publication date: 2016-12-01

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Authors: Pegah Khosraviyan, Mehdi Shafiee Ardestani, Mehdi Khoobi, Seyed Nasser Ostad, Farid Abedin Dorkoosh, Hamid Akbari Javar, Massoud Amanlou

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Concepts: Docetaxel, Mesoporous silica, Folate receptor, Nanoparticle, Chemistry, In vivo, Drug delivery, Mesoporous material, Folic acid, Cytotoxicity, Biophysics, Pharmacology, Cancer research, Nuclear chemistry, Nanotechnology, Cancer cell, Biochemistry, In vitro, Cancer, Materials science, Medicine, Organic chemistry, Catalysis, Internal medicine, Biology, Biotechnology

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Cited by: 111

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