Meta-Analysis Evaluating Risk of Hyperkalemia Stratified by Baseline MRA Usage in Patients with Heart Failure Receiving SGLT2 Inhibitors Article Swipe

PDF

Aymen Ahmed , Warda Ahmed , Muhammad Sameer Arshad , Azeema Suri , Emaan Amin , Izza Shahid , Muhammad Mustafa Memon ·

YOU? · · 2023 · Open Access · · DOI: https://doi.org/10.21203/rs.3.rs-2433685/v1

Mineralocorticoid receptor antagonists (MRAs) are guideline-recommended medications for patients with heart failure (HF) that reduce the risk of cardiovascular death and hospitalization, and improve survival. Evidence from recent clinical trials has indicated that the use of SGLT2is reduces the risk of HF hospitalization in HF patients with reduced ejection fraction (HFrEF) and preserved ejection fraction (HFpEF). The clinical benefit of these two drugs is based on highest level of clinical trial evidence. However, the risk of hyperkalemia limits the usage of MRAs (1). Considering this risk, both the current European Society of Cardiology (ESC) and American Heart Association/ American College of Cardiology (AHA/ACC) guidelines practice caution and recommend halving the dose and cessation of MRA therapy at serum potassium levels of >5.5 mmol/L and >6.0 mmol/L, respectively (2 – 4). SGLT2is exert diuretic effects and initially impair kidney function in patients. The combination of these two drugs is therefore expected to cause severe exacerbation in hyperkalemia. However, evidence from recent clinical trials has demonstrated that the use of SGLT2i may potentially reduce the rate of hyperkalemia when added to MRA therapy, and thus, can be used to optimize guideline-recommended MRA usage among patients with HF (5 – 7). Data regarding whether the concomitant use of both therapies reduces the risk of precipitating hyperkalemia among patients with HF is unclear. Therefore, we conducted a meta-analysis to evaluate the effect of baseline MRA therapy on the incidence of hyperkalemia in patients taking SGLT2is.

Related Topics

Concepts

Hyperkalemia Medicine Baseline (sea) Heart failure Internal medicine Meta-analysis Cardiology Intensive care medicine Geology Oceanography

Metadata

Type: preprint
Language: en
Landing Page: https://doi.org/10.21203/rs.3.rs-2433685/v1
PDF: https://www.researchsquare.com/article/rs-2433685/latest.pdf
OA Status: green
Cited By: 1
References: 3
Related Works: 10
OpenAlex ID: https://openalex.org/W4317241162

All OpenAlex metadata

Raw OpenAlex JSON

OpenAlex ID: https://openalex.org/W4317241162

Canonical identifier for this work in OpenAlex
DOI: https://doi.org/10.21203/rs.3.rs-2433685/v1

Digital Object Identifier
Title: Meta-Analysis Evaluating Risk of Hyperkalemia Stratified by Baseline MRA Usage in Patients with Heart Failure Receiving SGLT2 Inhibitors

Work title
Type: preprint

OpenAlex work type
Language: en

Primary language
Publication year: 2023

Year of publication
Publication date: 2023-01-18

Full publication date if available
Authors: Aymen Ahmed, Warda Ahmed, Muhammad Sameer Arshad, Azeema Suri, Emaan Amin, Izza Shahid, Muhammad Mustafa Memon

List of authors in order
Landing page: https://doi.org/10.21203/rs.3.rs-2433685/v1

Publisher landing page
PDF URL: https://www.researchsquare.com/article/rs-2433685/latest.pdf

Direct link to full text PDF
Open access: Yes

Whether a free full text is available
OA status: green

Open access status per OpenAlex
OA URL: https://www.researchsquare.com/article/rs-2433685/latest.pdf

Direct OA link when available
Concepts: Hyperkalemia, Medicine, Baseline (sea), Heart failure, Internal medicine, Meta-analysis, Cardiology, Intensive care medicine, Geology, Oceanography

Top concepts (fields/topics) attached by OpenAlex
Cited by: 1

Total citation count in OpenAlex
Citations by year (recent): 2023: 1

Per-year citation counts (last 5 years)
References (count): 3

Number of works referenced by this work
Related works (count): 10

Other works algorithmically related by OpenAlex

Full payload

id	https://openalex.org/W4317241162
doi	https://doi.org/10.21203/rs.3.rs-2433685/v1
ids.doi	https://doi.org/10.21203/rs.3.rs-2433685/v1
ids.openalex	https://openalex.org/W4317241162
fwci	0.33737499
type	preprint
title	Meta-Analysis Evaluating Risk of Hyperkalemia Stratified by Baseline MRA Usage in Patients with Heart Failure Receiving SGLT2 Inhibitors
biblio.issue
biblio.volume
biblio.last_page
biblio.first_page
topics[0].id	https://openalex.org/T12876
topics[0].field.id	https://openalex.org/fields/27
topics[0].field.display_name	Medicine
topics[0].score	0.9995999932289124
topics[0].domain.id	https://openalex.org/domains/4
topics[0].domain.display_name	Health Sciences
topics[0].subfield.id	https://openalex.org/subfields/2740
topics[0].subfield.display_name	Pulmonary and Respiratory Medicine
topics[0].display_name	Potassium and Related Disorders
topics[1].id	https://openalex.org/T10198
topics[1].field.id	https://openalex.org/fields/27
topics[1].field.display_name	Medicine
topics[1].score	0.9979000091552734
topics[1].domain.id	https://openalex.org/domains/4
topics[1].domain.display_name	Health Sciences
topics[1].subfield.id	https://openalex.org/subfields/2705
topics[1].subfield.display_name	Cardiology and Cardiovascular Medicine
topics[1].display_name	Heart Failure Treatment and Management
topics[2].id	https://openalex.org/T11967
topics[2].field.id	https://openalex.org/fields/27
topics[2].field.display_name	Medicine
topics[2].score	0.9926999807357788
topics[2].domain.id	https://openalex.org/domains/4
topics[2].domain.display_name	Health Sciences
topics[2].subfield.id	https://openalex.org/subfields/2740
topics[2].subfield.display_name	Pulmonary and Respiratory Medicine
topics[2].display_name	Electrolyte and hormonal disorders
is_xpac	False
apc_list
apc_paid
concepts[0].id	https://openalex.org/C2780243291
concepts[0].level	2
concepts[0].score	0.8934723734855652
concepts[0].wikidata	https://www.wikidata.org/wiki/Q605259
concepts[0].display_name	Hyperkalemia
concepts[1].id	https://openalex.org/C71924100
concepts[1].level	0
concepts[1].score	0.7051324844360352
concepts[1].wikidata	https://www.wikidata.org/wiki/Q11190
concepts[1].display_name	Medicine
concepts[2].id	https://openalex.org/C12725497
concepts[2].level	2
concepts[2].score	0.6620758771896362
concepts[2].wikidata	https://www.wikidata.org/wiki/Q810247
concepts[2].display_name	Baseline (sea)
concepts[3].id	https://openalex.org/C2778198053
concepts[3].level	2
concepts[3].score	0.6590681672096252
concepts[3].wikidata	https://www.wikidata.org/wiki/Q181754
concepts[3].display_name	Heart failure
concepts[4].id	https://openalex.org/C126322002
concepts[4].level	1
concepts[4].score	0.5502179861068726
concepts[4].wikidata	https://www.wikidata.org/wiki/Q11180
concepts[4].display_name	Internal medicine
concepts[5].id	https://openalex.org/C95190672
concepts[5].level	2
concepts[5].score	0.548843264579773
concepts[5].wikidata	https://www.wikidata.org/wiki/Q815382
concepts[5].display_name	Meta-analysis
concepts[6].id	https://openalex.org/C164705383
concepts[6].level	1
concepts[6].score	0.42768311500549316
concepts[6].wikidata	https://www.wikidata.org/wiki/Q10379
concepts[6].display_name	Cardiology
concepts[7].id	https://openalex.org/C177713679
concepts[7].level	1
concepts[7].score	0.3812488317489624
concepts[7].wikidata	https://www.wikidata.org/wiki/Q679690
concepts[7].display_name	Intensive care medicine
concepts[8].id	https://openalex.org/C127313418
concepts[8].level	0
concepts[8].score	0.0
concepts[8].wikidata	https://www.wikidata.org/wiki/Q1069
concepts[8].display_name	Geology
concepts[9].id	https://openalex.org/C111368507
concepts[9].level	1
concepts[9].score	0.0
concepts[9].wikidata	https://www.wikidata.org/wiki/Q43518
concepts[9].display_name	Oceanography
keywords[0].id	https://openalex.org/keywords/hyperkalemia
keywords[0].score	0.8934723734855652
keywords[0].display_name	Hyperkalemia
keywords[1].id	https://openalex.org/keywords/medicine
keywords[1].score	0.7051324844360352
keywords[1].display_name	Medicine
keywords[2].id	https://openalex.org/keywords/baseline
keywords[2].score	0.6620758771896362
keywords[2].display_name	Baseline (sea)
keywords[3].id	https://openalex.org/keywords/heart-failure
keywords[3].score	0.6590681672096252
keywords[3].display_name	Heart failure
keywords[4].id	https://openalex.org/keywords/internal-medicine
keywords[4].score	0.5502179861068726
keywords[4].display_name	Internal medicine
keywords[5].id	https://openalex.org/keywords/meta-analysis
keywords[5].score	0.548843264579773
keywords[5].display_name	Meta-analysis
keywords[6].id	https://openalex.org/keywords/cardiology
keywords[6].score	0.42768311500549316
keywords[6].display_name	Cardiology
keywords[7].id	https://openalex.org/keywords/intensive-care-medicine
keywords[7].score	0.3812488317489624
keywords[7].display_name	Intensive care medicine
language	en
locations[0].id	doi:10.21203/rs.3.rs-2433685/v1
locations[0].is_oa	True
locations[0].source.id	https://openalex.org/S4306402450
locations[0].source.issn
locations[0].source.type	repository
locations[0].source.is_oa	False
locations[0].source.issn_l
locations[0].source.is_core	False
locations[0].source.is_in_doaj	False
locations[0].source.display_name	Research Square (Research Square)
locations[0].source.host_organization	https://openalex.org/I4210096694
locations[0].source.host_organization_name	Research Square (United States)
locations[0].source.host_organization_lineage	https://openalex.org/I4210096694
locations[0].license	cc-by
locations[0].pdf_url	https://www.researchsquare.com/article/rs-2433685/latest.pdf
locations[0].version	acceptedVersion
locations[0].raw_type	posted-content
locations[0].license_id	https://openalex.org/licenses/cc-by
locations[0].is_accepted	True
locations[0].is_published	False
locations[0].raw_source_name
locations[0].landing_page_url	https://doi.org/10.21203/rs.3.rs-2433685/v1
indexed_in	crossref
authorships[0].author.id	https://openalex.org/A5090959241
authorships[0].author.orcid	https://orcid.org/0000-0003-0364-6475
authorships[0].author.display_name	Aymen Ahmed
authorships[0].countries	PK
authorships[0].affiliations[0].institution_ids	https://openalex.org/I118185606
authorships[0].affiliations[0].raw_affiliation_string	Aga Khan University Medical College Pakistan
authorships[0].institutions[0].id	https://openalex.org/I118185606
authorships[0].institutions[0].ror	https://ror.org/03gd0dm95
authorships[0].institutions[0].type	education
authorships[0].institutions[0].lineage	https://openalex.org/I118185606, https://openalex.org/I4210114929
authorships[0].institutions[0].country_code	PK
authorships[0].institutions[0].display_name	Aga Khan University
authorships[0].author_position	first
authorships[0].raw_author_name	Aymen Ahmed
authorships[0].is_corresponding	False
authorships[0].raw_affiliation_strings	Aga Khan University Medical College Pakistan
authorships[1].author.id	https://openalex.org/A5060994303
authorships[1].author.orcid	https://orcid.org/0000-0003-1528-2779
authorships[1].author.display_name	Warda Ahmed
authorships[1].countries	PK
authorships[1].affiliations[0].institution_ids	https://openalex.org/I118185606
authorships[1].affiliations[0].raw_affiliation_string	Aga Khan University Medical College Pakistan
authorships[1].institutions[0].id	https://openalex.org/I118185606
authorships[1].institutions[0].ror	https://ror.org/03gd0dm95
authorships[1].institutions[0].type	education
authorships[1].institutions[0].lineage	https://openalex.org/I118185606, https://openalex.org/I4210114929
authorships[1].institutions[0].country_code	PK
authorships[1].institutions[0].display_name	Aga Khan University
authorships[1].author_position	middle
authorships[1].raw_author_name	Warda Ahmed
authorships[1].is_corresponding	False
authorships[1].raw_affiliation_strings	Aga Khan University Medical College Pakistan
authorships[2].author.id	https://openalex.org/A5040520611
authorships[2].author.orcid	https://orcid.org/0000-0001-8551-1245
authorships[2].author.display_name	Muhammad Sameer Arshad
authorships[2].countries	PK
authorships[2].affiliations[0].institution_ids	https://openalex.org/I39727005
authorships[2].affiliations[0].raw_affiliation_string	Dow University of Health Sciences
authorships[2].institutions[0].id	https://openalex.org/I39727005
authorships[2].institutions[0].ror	https://ror.org/01h85hm56
authorships[2].institutions[0].type	education
authorships[2].institutions[0].lineage	https://openalex.org/I39727005
authorships[2].institutions[0].country_code	PK
authorships[2].institutions[0].display_name	Dow University of Health Sciences
authorships[2].author_position	middle
authorships[2].raw_author_name	Muhammad Sameer Arshad
authorships[2].is_corresponding	True
authorships[2].raw_affiliation_strings	Dow University of Health Sciences
authorships[3].author.id	https://openalex.org/A5003528406
authorships[3].author.orcid	https://orcid.org/0000-0001-5420-375X
authorships[3].author.display_name	Azeema Suri
authorships[3].countries	PK
authorships[3].affiliations[0].institution_ids	https://openalex.org/I39727005
authorships[3].affiliations[0].raw_affiliation_string	Dow University of Health Sciences
authorships[3].institutions[0].id	https://openalex.org/I39727005
authorships[3].institutions[0].ror	https://ror.org/01h85hm56
authorships[3].institutions[0].type	education
authorships[3].institutions[0].lineage	https://openalex.org/I39727005
authorships[3].institutions[0].country_code	PK
authorships[3].institutions[0].display_name	Dow University of Health Sciences
authorships[3].author_position	middle
authorships[3].raw_author_name	Azeema Suri
authorships[3].is_corresponding	False
authorships[3].raw_affiliation_strings	Dow University of Health Sciences
authorships[4].author.id	https://openalex.org/A5112706588
authorships[4].author.orcid
authorships[4].author.display_name	Emaan Amin
authorships[4].countries	PK, US
authorships[4].affiliations[0].institution_ids	https://openalex.org/I1295876152, https://openalex.org/I39727005
authorships[4].affiliations[0].raw_affiliation_string	Dow University of Health Sciences Izza Shahid Houston Methodist Academic Institute
authorships[4].institutions[0].id	https://openalex.org/I39727005
authorships[4].institutions[0].ror	https://ror.org/01h85hm56
authorships[4].institutions[0].type	education
authorships[4].institutions[0].lineage	https://openalex.org/I39727005
authorships[4].institutions[0].country_code	PK
authorships[4].institutions[0].display_name	Dow University of Health Sciences
authorships[4].institutions[1].id	https://openalex.org/I1295876152
authorships[4].institutions[1].ror	https://ror.org/027zt9171
authorships[4].institutions[1].type	healthcare
authorships[4].institutions[1].lineage	https://openalex.org/I1295876152
authorships[4].institutions[1].country_code	US
authorships[4].institutions[1].display_name	Houston Methodist
authorships[4].author_position	middle
authorships[4].raw_author_name	Emaan Amin
authorships[4].is_corresponding	False
authorships[4].raw_affiliation_strings	Dow University of Health Sciences Izza Shahid Houston Methodist Academic Institute
authorships[5].author.id	https://openalex.org/A5053329002
authorships[5].author.orcid	https://orcid.org/0000-0003-3975-1197
authorships[5].author.display_name	Izza Shahid
authorships[5].countries	US
authorships[5].affiliations[0].institution_ids	https://openalex.org/I1295876152
authorships[5].affiliations[0].raw_affiliation_string	Houston Methodist Academic Institute
authorships[5].institutions[0].id	https://openalex.org/I1295876152
authorships[5].institutions[0].ror	https://ror.org/027zt9171
authorships[5].institutions[0].type	healthcare
authorships[5].institutions[0].lineage	https://openalex.org/I1295876152
authorships[5].institutions[0].country_code	US
authorships[5].institutions[0].display_name	Houston Methodist
authorships[5].author_position	middle
authorships[5].raw_author_name	Izza Shahid
authorships[5].is_corresponding	False
authorships[5].raw_affiliation_strings	Houston Methodist Academic Institute
authorships[6].author.id	https://openalex.org/A5053817015
authorships[6].author.orcid	https://orcid.org/0000-0001-5522-9716
authorships[6].author.display_name	Muhammad Mustafa Memon
authorships[6].countries	PK
authorships[6].affiliations[0].institution_ids	https://openalex.org/I39727005
authorships[6].affiliations[0].raw_affiliation_string	Dow University of Health Sciences
authorships[6].institutions[0].id	https://openalex.org/I39727005
authorships[6].institutions[0].ror	https://ror.org/01h85hm56
authorships[6].institutions[0].type	education
authorships[6].institutions[0].lineage	https://openalex.org/I39727005
authorships[6].institutions[0].country_code	PK
authorships[6].institutions[0].display_name	Dow University of Health Sciences
authorships[6].author_position	last
authorships[6].raw_author_name	Muhammad Mustafa Memon
authorships[6].is_corresponding	False
authorships[6].raw_affiliation_strings	Dow University of Health Sciences
has_content.pdf	True
has_content.grobid_xml	True
is_paratext	False
open_access.is_oa	True
open_access.oa_url	https://www.researchsquare.com/article/rs-2433685/latest.pdf
open_access.oa_status	green
open_access.any_repository_has_fulltext	False
created_date	2025-10-10T00:00:00
display_name	Meta-Analysis Evaluating Risk of Hyperkalemia Stratified by Baseline MRA Usage in Patients with Heart Failure Receiving SGLT2 Inhibitors
has_fulltext	True
is_retracted	False
updated_date	2025-11-06T03:46:38.306776
primary_topic.id	https://openalex.org/T12876
primary_topic.field.id	https://openalex.org/fields/27
primary_topic.field.display_name	Medicine
primary_topic.score	0.9995999932289124
primary_topic.domain.id	https://openalex.org/domains/4
primary_topic.domain.display_name	Health Sciences
primary_topic.subfield.id	https://openalex.org/subfields/2740
primary_topic.subfield.display_name	Pulmonary and Respiratory Medicine
primary_topic.display_name	Potassium and Related Disorders
related_works	https://openalex.org/W1577251610, https://openalex.org/W2006586291, https://openalex.org/W4376471865, https://openalex.org/W3214249464, https://openalex.org/W4292006139, https://openalex.org/W2741567003, https://openalex.org/W3213936688, https://openalex.org/W4322742330, https://openalex.org/W1990676725, https://openalex.org/W2052349502
cited_by_count	1
counts_by_year[0].year	2023
counts_by_year[0].cited_by_count	1
locations_count	1
best_oa_location.id	doi:10.21203/rs.3.rs-2433685/v1
best_oa_location.is_oa	True
best_oa_location.source.id	https://openalex.org/S4306402450
best_oa_location.source.issn
best_oa_location.source.type	repository
best_oa_location.source.is_oa	False
best_oa_location.source.issn_l
best_oa_location.source.is_core	False
best_oa_location.source.is_in_doaj	False
best_oa_location.source.display_name	Research Square (Research Square)
best_oa_location.source.host_organization	https://openalex.org/I4210096694
best_oa_location.source.host_organization_name	Research Square (United States)
best_oa_location.source.host_organization_lineage	https://openalex.org/I4210096694
best_oa_location.license	cc-by
best_oa_location.pdf_url	https://www.researchsquare.com/article/rs-2433685/latest.pdf
best_oa_location.version	acceptedVersion
best_oa_location.raw_type	posted-content
best_oa_location.license_id	https://openalex.org/licenses/cc-by
best_oa_location.is_accepted	True
best_oa_location.is_published	False
best_oa_location.raw_source_name
best_oa_location.landing_page_url	https://doi.org/10.21203/rs.3.rs-2433685/v1
primary_location.id	doi:10.21203/rs.3.rs-2433685/v1
primary_location.is_oa	True
primary_location.source.id	https://openalex.org/S4306402450
primary_location.source.issn
primary_location.source.type	repository
primary_location.source.is_oa	False
primary_location.source.issn_l
primary_location.source.is_core	False
primary_location.source.is_in_doaj	False
primary_location.source.display_name	Research Square (Research Square)
primary_location.source.host_organization	https://openalex.org/I4210096694
primary_location.source.host_organization_name	Research Square (United States)
primary_location.source.host_organization_lineage	https://openalex.org/I4210096694
primary_location.license	cc-by
primary_location.pdf_url	https://www.researchsquare.com/article/rs-2433685/latest.pdf
primary_location.version	acceptedVersion
primary_location.raw_type	posted-content
primary_location.license_id	https://openalex.org/licenses/cc-by
primary_location.is_accepted	True
primary_location.is_published	False
primary_location.raw_source_name
primary_location.landing_page_url	https://doi.org/10.21203/rs.3.rs-2433685/v1
publication_date	2023-01-18
publication_year	2023
referenced_works	https://openalex.org/W7073974198, https://openalex.org/W4220703019, https://openalex.org/W3137609010
referenced_works_count	3
abstract_inverted_index.a	223
abstract_inverted_index.(2	128
abstract_inverted_index.(5	196
abstract_inverted_index.HF	42, 45, 195, 217
abstract_inverted_index.at	117
abstract_inverted_index.be	185
abstract_inverted_index.in	44, 140, 155, 238
abstract_inverted_index.is	64, 148, 218
abstract_inverted_index.of	18, 36, 41, 60, 69, 76, 81, 92, 101, 114, 121, 144, 168, 175, 205, 211, 229, 236
abstract_inverted_index.on	66, 233
abstract_inverted_index.to	151, 179, 187, 225
abstract_inverted_index.we	221
abstract_inverted_index.4).	130
abstract_inverted_index.7).	198
abstract_inverted_index.MRA	115, 180, 190, 231
abstract_inverted_index.The	57, 142
abstract_inverted_index.and	21, 23, 52, 95, 107, 112, 124, 135, 182
abstract_inverted_index.are	5
abstract_inverted_index.can	184
abstract_inverted_index.for	8
abstract_inverted_index.has	31, 163
abstract_inverted_index.may	170
abstract_inverted_index.the	16, 34, 39, 74, 79, 88, 110, 166, 173, 202, 209, 227, 234
abstract_inverted_index.two	62, 146
abstract_inverted_index.use	35, 167, 204
abstract_inverted_index.–	129, 197
abstract_inverted_index.(1).	83
abstract_inverted_index.(HF)	13
abstract_inverted_index.Data	199
abstract_inverted_index.MRAs	82
abstract_inverted_index.both	87, 206
abstract_inverted_index.dose	111
abstract_inverted_index.from	27, 159
abstract_inverted_index.rate	174
abstract_inverted_index.risk	17, 40, 75, 210
abstract_inverted_index.that	14, 33, 165
abstract_inverted_index.this	85
abstract_inverted_index.used	186
abstract_inverted_index.when	177
abstract_inverted_index.with	10, 47, 194, 216
abstract_inverted_index.(ESC)	94
abstract_inverted_index.Heart	97
abstract_inverted_index.added	178
abstract_inverted_index.among	192, 214
abstract_inverted_index.based	65
abstract_inverted_index.cause	152
abstract_inverted_index.death	20
abstract_inverted_index.drugs	63, 147
abstract_inverted_index.exert	132
abstract_inverted_index.heart	11
abstract_inverted_index.level	68
abstract_inverted_index.risk,	86
abstract_inverted_index.serum	118
abstract_inverted_index.these	61, 145
abstract_inverted_index.thus,	183
abstract_inverted_index.trial	71
abstract_inverted_index.usage	80, 191
abstract_inverted_index.(MRAs)	4
abstract_inverted_index.SGLT2i	169
abstract_inverted_index.effect	228
abstract_inverted_index.impair	137
abstract_inverted_index.kidney	138
abstract_inverted_index.levels	120
abstract_inverted_index.limits	78
abstract_inverted_index.mmol/L	123
abstract_inverted_index.recent	28, 160
abstract_inverted_index.reduce	15, 172
abstract_inverted_index.severe	153
abstract_inverted_index.taking	240
abstract_inverted_index.trials	30, 162
abstract_inverted_index.>5.5	122
abstract_inverted_index.>6.0	125
abstract_inverted_index.(HFrEF)	51
abstract_inverted_index.College	100
abstract_inverted_index.SGLT2is	37, 131
abstract_inverted_index.Society	91
abstract_inverted_index.benefit	59
abstract_inverted_index.caution	106
abstract_inverted_index.current	89
abstract_inverted_index.effects	134
abstract_inverted_index.failure	12
abstract_inverted_index.halving	109
abstract_inverted_index.highest	67
abstract_inverted_index.improve	24
abstract_inverted_index.mmol/L,	126
abstract_inverted_index.reduced	48
abstract_inverted_index.reduces	38, 208
abstract_inverted_index.therapy	116, 232
abstract_inverted_index.whether	201
abstract_inverted_index.(HFpEF).	56
abstract_inverted_index.Abstract	0
abstract_inverted_index.American	96, 99
abstract_inverted_index.European	90
abstract_inverted_index.Evidence	26
abstract_inverted_index.However,	73, 157
abstract_inverted_index.SGLT2is.	241
abstract_inverted_index.baseline	230
abstract_inverted_index.clinical	29, 58, 70, 161
abstract_inverted_index.diuretic	133
abstract_inverted_index.ejection	49, 54
abstract_inverted_index.evaluate	226
abstract_inverted_index.evidence	158
abstract_inverted_index.expected	150
abstract_inverted_index.fraction	50, 55
abstract_inverted_index.function	139
abstract_inverted_index.optimize	188
abstract_inverted_index.patients	9, 46, 193, 215, 239
abstract_inverted_index.practice	105
abstract_inverted_index.receptor	2
abstract_inverted_index.therapy,	181
abstract_inverted_index.unclear.	219
abstract_inverted_index.(AHA/ACC)	103
abstract_inverted_index.cessation	113
abstract_inverted_index.conducted	222
abstract_inverted_index.evidence.	72
abstract_inverted_index.incidence	235
abstract_inverted_index.indicated	32
abstract_inverted_index.initially	136
abstract_inverted_index.patients.	141
abstract_inverted_index.potassium	119
abstract_inverted_index.preserved	53
abstract_inverted_index.recommend	108
abstract_inverted_index.regarding	200
abstract_inverted_index.survival.	25
abstract_inverted_index.therapies	207
abstract_inverted_index.therefore	149
abstract_inverted_index.Cardiology	93, 102
abstract_inverted_index.Therefore,	220
abstract_inverted_index.guidelines	104
abstract_inverted_index.Considering	84
abstract_inverted_index.antagonists	3
abstract_inverted_index.combination	143
abstract_inverted_index.concomitant	203
abstract_inverted_index.medications	7
abstract_inverted_index.potentially	171
abstract_inverted_index.Association/	98
abstract_inverted_index.demonstrated	164
abstract_inverted_index.exacerbation	154
abstract_inverted_index.hyperkalemia	77, 176, 213, 237
abstract_inverted_index.respectively	127
abstract_inverted_index.hyperkalemia.	156
abstract_inverted_index.meta-analysis	224
abstract_inverted_index.precipitating	212
abstract_inverted_index.cardiovascular	19
abstract_inverted_index.hospitalization	43
abstract_inverted_index.hospitalization,	22
abstract_inverted_index.Mineralocorticoid	1
abstract_inverted_index.guideline-recommended	6, 189
cited_by_percentile_year.max	94
cited_by_percentile_year.min	89
corresponding_author_ids	https://openalex.org/A5040520611
countries_distinct_count	2
institutions_distinct_count	7
corresponding_institution_ids	https://openalex.org/I39727005
sustainable_development_goals[0].id	https://metadata.un.org/sdg/3
sustainable_development_goals[0].score	0.8700000047683716
sustainable_development_goals[0].display_name	Good health and well-being
citation_normalized_percentile.value	0.600875
citation_normalized_percentile.is_in_top_1_percent	False
citation_normalized_percentile.is_in_top_10_percent	False