Meta-analysis of randomized controlled trials on primary ambulatory thromboprophylaxis in patients with nonpancreatic gastrointestinal cancers receiving chemotherapy Article Swipe
Thura Win Htut
,
Kyaw Zin Thein
,
Donald P. Quick
,
Thein H. Oo
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1080/08998280.2021.1973340
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1080/08998280.2021.1973340
Primary ambulatory thromboprophylaxis (PATP) in patients with solid malignancies is not routinely indicated. We performed a meta-analysis of randomized controlled trials (RCTs) to determine the benefit and risk of PATP in patients with nonpancreatic gastrointestinal cancers receiving chemotherapy. RCTs with venous thromboembolism (VTE) reduction as primary or secondary endpoints were included. A total of 1932 patients from subgroups of 3 RCTs were eligible. The VTE incidence was 1.26% and 2.55% in PATP and control arms, respectively (risk ratio 0.49; confidence interval 0.25 to 0.96; P = 0.04), with a number needed to treat of 78 to prevent one VTE event. In gastric and gastroesophageal junction cancer patients, the VTE incidence was 1.37% and 3.40% in PATP and control arms, respectively (risk ratio 0.40; confidence interval 0.13 to 1.24; P = 0.11). PATP should not be recommended in patients with nonpancreatic gastrointestinal cancers on chemotherapy.
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Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1080/08998280.2021.1973340
- OA Status
- green
- References
- 26
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3200420363
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3200420363Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1080/08998280.2021.1973340Digital Object Identifier
- Title
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Meta-analysis of randomized controlled trials on primary ambulatory thromboprophylaxis in patients with nonpancreatic gastrointestinal cancers receiving chemotherapyWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2021Year of publication
- Publication date
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2021-09-16Full publication date if available
- Authors
-
Thura Win Htut, Kyaw Zin Thein, Donald P. Quick, Thein H. OoList of authors in order
- Landing page
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https://doi.org/10.1080/08998280.2021.1973340Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
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greenOpen access status per OpenAlex
- OA URL
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https://www.ncbi.nlm.nih.gov/pmc/articles/8682846Direct OA link when available
- Concepts
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Medicine, Ambulatory, Internal medicine, Confidence interval, Randomized controlled trial, Incidence (geometry), Chemotherapy, Cancer, Hazard ratio, Gastrointestinal cancer, Gastroenterology, Oncology, Colorectal cancer, Physics, OpticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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26Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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