Meta-analysis of the association between emphysematous change on thoracic computerized tomography scan and recurrent pneumothorax Article Swipe
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· 2021
· Open Access
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· DOI: https://doi.org/10.1093/qjmed/hcab020
Summary Objectives At least a third of patients go on to suffer a recurrence following a first spontaneous pneumothorax. Surgical intervention reduces the risk of recurrence and has been advocated as a primary treatment for pneumothorax. But surgery exposes patients to the risks of anaesthesia and in some cases can cause chronic pain. Risk stratification of patients to identify those most at risk of recurrence would help direct the most appropriate patients to early intervention. Many studies have addressed the role of thoracic computerized tomography (CT) in identifying those individuals at increased risk of recurrence, but a consensus is lacking. Aim Our objective was to clarify whether CT provides valuable prognostic information for recurrent pneumothorax. Design Meta-analysis. Methods We conducted an exhaustive search of the literature for thoracic CT imaging and pneumothorax, and then performed a meta-analysis using a random effects model to estimate the common odds ratio and standard error. Results Here, we show by meta-analysis of data from 2475 individuals that emphysematous change on CT scan is associated with a significant increased odds ratio for recurrent pneumothorax ipsilateral to the radiological abnormality (odds ratio 2.49, 95% confidence interval 1.51–4.13). Conclusions The association holds true for primary spontaneous pneumothorax when considering emphysematous changes including blebs and bullae. Features, such as bullae at the azygoesophageal recess or increased Goddard score similarly predicted recurrent secondary pneumothorax, as shown by subgroup analysis. Our meta-analysis suggests that CT scanning has value in risk stratifying patients considering surgery for pneumothorax.
Related Topics
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.1093/qjmed/hcab020
- https://academic.oup.com/qjmed/advance-article-pdf/doi/10.1093/qjmed/hcab020/41109395/hcab020.pdf
- OA Status
- hybrid
- Cited By
- 3
- References
- 46
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3126382503
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3126382503Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1093/qjmed/hcab020Digital Object Identifier
- Title
-
Meta-analysis of the association between emphysematous change on thoracic computerized tomography scan and recurrent pneumothoraxWork title
- Type
-
reviewOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-01-21Full publication date if available
- Authors
-
Milind Girish, Paul D.P. Pharoah, Stefan J. MarciniakList of authors in order
- Landing page
-
https://doi.org/10.1093/qjmed/hcab020Publisher landing page
- PDF URL
-
https://academic.oup.com/qjmed/advance-article-pdf/doi/10.1093/qjmed/hcab020/41109395/hcab020.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
-
https://academic.oup.com/qjmed/advance-article-pdf/doi/10.1093/qjmed/hcab020/41109395/hcab020.pdfDirect OA link when available
- Concepts
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Medicine, Pneumothorax, Odds ratio, Confidence interval, Meta-analysis, Radiology, Abnormality, Surgery, Internal medicine, PsychiatryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
3Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 2, 2024: 1Per-year citation counts (last 5 years)
- References (count)
-
46Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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