Metabolic and immune heterogeneity in stroke: Insights into subtype identification and biomarker discovery Article Swipe

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Wei Wang , Qiuyang Qian , Zhigang Guo , Fang-Yi Lin , Wei-Ming Lin , Zhigang Yuan , Mei Shen ·

YOU? · · 2025 · Open Access · · DOI: https://doi.org/10.1371/journal.pone.0323172

Stroke is a leading cause of mortality and long-term disability worldwide, characterized by substantial molecular and clinical heterogeneity. This study aimed to investigate the metabolic and immune-related mechanisms underlying stroke subtypes using transcriptomic data and advanced computational tools. Gene expression data from two GEO datasets (GSE16561 and GSE58294) were preprocessed, batch-corrected, and integrated. Consensus clustering based on 2,752 metabolism-related genes identified three distinct subtypes with significant differences in metabolic activity. GSVA analysis revealed subtype-specific variations in key pathways, such as the citrate cycle, glycolysis, and glycosaminoglycan biosynthesis, highlighting their metabolic diversity.

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Computational biology Biology Transcriptome Biomarker discovery Metabolic pathway Gene Bioinformatics Biomarker Immune system Genetics Gene expression Proteomics

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Type: article
Language: en
Landing Page: https://doi.org/10.1371/journal.pone.0323172
OA Status: gold
References: 32
Related Works: 10
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DOI: https://doi.org/10.1371/journal.pone.0323172

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Title: Metabolic and immune heterogeneity in stroke: Insights into subtype identification and biomarker discovery

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Type: article

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Language: en

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Publication year: 2025

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Publication date: 2025-05-21

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Authors: Wei Wang, Qiuyang Qian, Zhigang Guo, Fang-Yi Lin, Wei-Ming Lin, Zhigang Yuan, Mei Shen

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Landing page: https://doi.org/10.1371/journal.pone.0323172

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OA URL: https://doi.org/10.1371/journal.pone.0323172

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Concepts: Computational biology, Biology, Transcriptome, Biomarker discovery, Metabolic pathway, Gene, Bioinformatics, Biomarker, Immune system, Genetics, Gene expression, Proteomics

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References (count): 32

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Related works (count): 10

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