Metabolic disorders exacerbate the formation of glial scar after stroke Article Swipe
Julien Clain
,
C. David
,
Matthieu Bringart
,
Arnaud Lecadieu
,
Olivier Meilhac
,
Christian Lefebvre d’Hellencourt
,
Nicolas Diotel
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1111/ejn.16325
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1111/ejn.16325
Metabolic disorders are risk factors for stroke exacerbating subsequent complications. Rapidly after brain injury, a glial scar forms, preventing excessive inflammation and limiting axonal regeneration. Despite the growing interest in wound healing following brain injury, the formation of a glial scar in the context of metabolic disorders is poorly documented. In this study, we used db/db mice to investigate the impact of metabolic perturbations on brain repair mechanisms, with a focus on glial scarring. First, we confirmed the development of obesity, poor glucose regulation, hyperglycaemia and liver steatosis in these mice. Then, we observed that 3 days after a 30‐min middle cerebral artery occlusion (MCAO), db/db mice had larger infarct area compared with their control counterparts. We next investigated reactive gliosis and glial scar formation in db/+ and db/db mice. We demonstrated that astrogliosis and microgliosis were exacerbated 3 days after stroke in db/db mice. Furthermore, we also showed that the synthesis of extracellular matrix (ECM) proteins (i.e., chondroitin sulphate proteoglycan, collagen IV and tenascin C) was increased in db/db mice. Consequently, we demonstrated for the first time that metabolic disorders impair reactive gliosis post‐stroke and increase ECM deposition. Given that the damage size is known to influence glial scar, this study now raises the question of the direct impact of hyperglycaemia/obesity on reactive gliosis and glia scar. It paves the way to promote the development of new therapies targeting glial scar formation to improve functional recovery after stroke in the context of metabolic disorders.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1111/ejn.16325
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/ejn.16325
- OA Status
- hybrid
- Cited By
- 7
- References
- 67
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4393987526
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4393987526Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1111/ejn.16325Digital Object Identifier
- Title
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Metabolic disorders exacerbate the formation of glial scar after strokeWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-04-04Full publication date if available
- Authors
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Julien Clain, C. David, Matthieu Bringart, Arnaud Lecadieu, Olivier Meilhac, Christian Lefebvre d’Hellencourt, Nicolas DiotelList of authors in order
- Landing page
-
https://doi.org/10.1111/ejn.16325Publisher landing page
- PDF URL
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/ejn.16325Direct link to full text PDF
- Open access
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YesWhether a free full text is available
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-
hybridOpen access status per OpenAlex
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/ejn.16325Direct OA link when available
- Concepts
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Astrogliosis, Glial scar, Gliosis, Context (archaeology), Medicine, Stroke (engine), Pathology, Neuroscience, Endocrinology, Internal medicine, Astrocyte, Biology, Central nervous system, Paleontology, Engineering, Mechanical engineeringTop concepts (fields/topics) attached by OpenAlex
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7Total citation count in OpenAlex
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2025: 2, 2024: 5Per-year citation counts (last 5 years)
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67Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| corresponding_author_ids | https://openalex.org/A5003927719, https://openalex.org/A5043170116 |
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| corresponding_institution_ids | https://openalex.org/I154526488, https://openalex.org/I4210157513 |
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