Metabolic, Mitochondrial, and Inflammatory Effects of Efavirenz, Emtricitabine, and Tenofovir Disoproxil Fumarate in Asymptomatic Antiretroviral-Naïve People with HIV Article Swipe
Sergio Espuelas Barroso
,
Mariona Guitart‐Mampel
,
Francesc Josep García‐García
,
Judith Cantó‐Santos
,
Laura Valls‐Roca
,
Félix Andújar-Sánchez
,
Adrià Vilaseca-Capel
,
Ester Tobías
,
Angela Arias-Dimas
,
Tania Quesada‐López
,
Rafael Artuch
,
Francesc Villarroya
,
Marta Giralt
,
Estebán Martínez
,
Ester Lozano
,
Glòria Garrabou
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/ijms25158418
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/ijms25158418
This study aimed to comprehensively assess the metabolic, mitochondrial, and inflammatory effects of first-line efavirenz, emtricitabine, and tenofovir disoproxil fumarate (EFV/FTC/TDF) single-tablet regimen (STR) relative to untreated asymptomatic HIV infection. To this end, we analyzed 29 people with HIV (PWH) treated for at least one year with this regimen vs. 33 antiretroviral-naïve PWH. Excellent therapeutic activity was accompanied by significant alterations in metabolic parameters. The treatment group showed increased plasmatic levels of glucose, total cholesterol and its fractions (LDL and HDL), triglycerides, and hepatic enzymes (GGT, ALP); conversely, bilirubin levels (total and indirect fraction) decreased in the treated cohort. Mitochondrial performance was preserved overall and treatment administration even promoted the recovery of mitochondrial DNA (mtDNA) content depleted by the virus, although this was not accompanied by the recovery in some of their encoded proteins (since cytochrome c oxidase II was significantly decreased). Inflammatory profile (TNFα, IL-6), ameliorated after treatment in accordance with viral reduction and the recovery of TNFα levels correlated to mtDNA cell restoration. Thus, although this regimen causes subclinical metabolic alterations, its antiviral and anti-inflammatory properties may be associated with partial improvement in mitochondrial function.
Related Topics
Concepts
Efavirenz
Emtricitabine
Regimen
Pharmacology
Asymptomatic
Internal medicine
Medicine
Ritonavir
Lamivudine
Virology
Viral load
Human immunodeficiency virus (HIV)
Virus
Antiretroviral therapy
Hepatitis B virus
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/ijms25158418
- OA Status
- gold
- Cited By
- 2
- References
- 83
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4401213207
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4401213207Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/ijms25158418Digital Object Identifier
- Title
-
Metabolic, Mitochondrial, and Inflammatory Effects of Efavirenz, Emtricitabine, and Tenofovir Disoproxil Fumarate in Asymptomatic Antiretroviral-Naïve People with HIVWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-08-01Full publication date if available
- Authors
-
Sergio Espuelas Barroso, Mariona Guitart‐Mampel, Francesc Josep García‐García, Judith Cantó‐Santos, Laura Valls‐Roca, Félix Andújar-Sánchez, Adrià Vilaseca-Capel, Ester Tobías, Angela Arias-Dimas, Tania Quesada‐López, Rafael Artuch, Francesc Villarroya, Marta Giralt, Estebán Martínez, Ester Lozano, Glòria GarrabouList of authors in order
- Landing page
-
https://doi.org/10.3390/ijms25158418Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.3390/ijms25158418Direct OA link when available
- Concepts
-
Efavirenz, Emtricitabine, Regimen, Pharmacology, Asymptomatic, Internal medicine, Medicine, Ritonavir, Lamivudine, Virology, Viral load, Human immunodeficiency virus (HIV), Virus, Antiretroviral therapy, Hepatitis B virusTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
2Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 2Per-year citation counts (last 5 years)
- References (count)
-
83Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| title | Metabolic, Mitochondrial, and Inflammatory Effects of Efavirenz, Emtricitabine, and Tenofovir Disoproxil Fumarate in Asymptomatic Antiretroviral-Naïve People with HIV |
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