Metabolic trade-offs constrain the cell size ratio in a nitrogen-fixing symbiosis Article Swipe

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Francisco M. Cornejo‐Castillo , Keisuke Inomura , Jonathan P. Zehr , Michael J. Follows ·

YOU? · · 2024 · Open Access · · DOI: https://doi.org/10.1016/j.cell.2024.02.016

Biological dinitrogen (N₂) fixation is a key metabolic process exclusively performed by prokaryotes, some of which are symbiotic with eukaryotes. Species of the marine haptophyte algae Braarudosphaera bigelowii harbor the N₂-fixing endosymbiotic cyanobacteria UCYN-A, which might be evolving organelle-like characteristics. We found that the size ratio between UCYN-A and their hosts is strikingly conserved across sublineages/species, which is consistent with the size relationships of organelles in this symbiosis and other species. Metabolic modeling showed that this size relationship maximizes the coordinated growth rate based on trade-offs between resource acquisition and exchange. Our findings show that the size relationships of N₂-fixing endosymbionts and organelles in unicellular eukaryotes are constrained by predictable metabolic underpinnings and that UCYN-A is, in many regards, functioning like a hypothetical N₂-fixing organelle (or nitroplast).

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Computational Biology

Bacteria

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Biology Symbiosis Nitrogen fixation Cell size Cell biology Computational biology Genetics Bacteria

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Type: article
Language: en
Landing Page: https://doi.org/10.1016/j.cell.2024.02.016
PDF: http://www.cell.com/article/S009286742400182X/pdf
OA Status: hybrid
Cited By: 26
References: 69
Related Works: 10
OpenAlex ID: https://openalex.org/W4392650468

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DOI: https://doi.org/10.1016/j.cell.2024.02.016

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Title: Metabolic trade-offs constrain the cell size ratio in a nitrogen-fixing symbiosis

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Type: article

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Language: en

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Publication year: 2024

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Publication date: 2024-03-01

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Authors: Francisco M. Cornejo‐Castillo, Keisuke Inomura, Jonathan P. Zehr, Michael J. Follows

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Landing page: https://doi.org/10.1016/j.cell.2024.02.016

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PDF URL: https://www.cell.com/article/S009286742400182X/pdf

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OA URL: https://www.cell.com/article/S009286742400182X/pdf

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Concepts: Biology, Symbiosis, Nitrogen fixation, Cell size, Cell biology, Computational biology, Genetics, Bacteria

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Cited by: 26

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Citations by year (recent): 2025: 10, 2024: 16

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Related works (count): 10

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