Metabolite identification of salvianolic acid A in rat using post collision-induced dissociation energy-resolved mass spectrometry Article Swipe
Li Han
,
Ke Zhang
,
Wei Chen
,
Yuxuan Zhou
,
Jun Li
,
Yunfang Zhao
,
Yuelin Song
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1186/s13020-024-00931-z
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1186/s13020-024-00931-z
Background As one of the most famous natural products, salvianolic acid A (SAA) is undergoing clinical trials for the treatments of angina pectoris and coronary heart disorders. However, the in vivo metabolites of SAA have only been tentatively identified, leading to a barrier for precise therapeutical drug monitoring. Methods Ultra-high performance liquid chromatography coupled with quadrupole time of flight tandem mass spectrometry (UPLC–Qtof-MS/MS) was firstly employed to acquire high-resolution MS 1 and MS 2 spectra for all metabolites. Through paying special attention onto the features of ester bond dissociation, metabolism sites were restricted at certain regions. To further determine the metabolism site, such as the monomethylated products ( M23 , M25 , and M26 ), post collision-induced dissociation energy-resolved mass spectrometry (post-CID ER-MS) was proposed through programming progressive exciting energies to the second collision chamber of hybrid triple quadrupole-linear ion trap mass spectrometry (Qtrap-MS) device. Results After SAA oral administration, 29 metabolites ( M1 – M29 ), including five, thirteen, and sixteen ones in rat plasma, urine, and feces, respectively, were detected in rats. The metabolism route was initially determined by applying well-defined mass fragmentation pathways to those HR- m / z values of precursor and fragment ions. Metabolism site was limited to SAF- or DSS-unit based on the fragmentation patterns of ester functional group. Through matching the dissociation trajectories of concerned 1 st -generation fragment ions with expected decomposition product anions using post-CID ER-MS strategy, M23 and M25 were unequivocally assigned as 3'-methyl-SAA and 3''-methyl-SAA, and M26 was identified as 2-methyl-SAA or 3-methyl-SAA. Hydrolysis, methylation, glucuronidation, sulfation, and oxidation were the primary metabolism channels being responsible for the metabolites' generation. Conclusion Together, the metabolism regions and sites of SAA metabolites were sequentially identified based on the ester bond dissociation features and post-CID ER-MS strategy. Importantly, the present study provided a promising way to elevate the structural identification confidence of natural products and metabolites. Graphical abstract
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- article
- Language
- en
- Landing Page
- https://doi.org/10.1186/s13020-024-00931-z
- https://cmjournal.biomedcentral.com/counter/pdf/10.1186/s13020-024-00931-z
- OA Status
- gold
- Cited By
- 4
- References
- 41
- Related Works
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- OpenAlex ID
- https://openalex.org/W4395675445
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https://openalex.org/W4395675445Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1186/s13020-024-00931-zDigital Object Identifier
- Title
-
Metabolite identification of salvianolic acid A in rat using post collision-induced dissociation energy-resolved mass spectrometryWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-04-26Full publication date if available
- Authors
-
Li Han, Ke Zhang, Wei Chen, Yuxuan Zhou, Jun Li, Yunfang Zhao, Yuelin SongList of authors in order
- Landing page
-
https://doi.org/10.1186/s13020-024-00931-zPublisher landing page
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https://cmjournal.biomedcentral.com/counter/pdf/10.1186/s13020-024-00931-zDirect link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://cmjournal.biomedcentral.com/counter/pdf/10.1186/s13020-024-00931-zDirect OA link when available
- Concepts
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Mass spectrometry, Metabolite, Metabolomics, Chemistry, Collision-induced dissociation, Dissociation (chemistry), Gas chromatography–mass spectrometry, Chromatography, Biochemistry, Tandem mass spectrometry, Organic chemistryTop concepts (fields/topics) attached by OpenAlex
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4Total citation count in OpenAlex
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2025: 3, 2020: 1Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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