Metabolomic Relationships Between Lung Cancer and Alzheimer's Disease Using Serum Nuclear Magnetic Resonance Spectroscopy Article Swipe
Zuzanna Kobus
,
Marta Kobus
,
Ella Zhang
,
Rajshree Ghosh Biswas
,
J. Chen
,
Piet Habbel
,
Johannes Nowak
,
Li Su
,
David Kaul
,
Steven E. Arnold
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1002/nbm.70186
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1002/nbm.70186
Lung cancer (LC) and Alzheimer's disease (AD) are both age‐associated diseases with high rates of mortality. Studies have reported a possible inverse relationship between LC and AD incidences; however, possible shared molecular mechanisms have not been well investigated. Better characterizations of both diseases and their potential molecular relationships may advance the development of successful therapies for both LC and AD. Metabolomics, as a holistic study of the entire measurable metabolome, has the potential to probe into their metabolic connections. Herein, we used high‐resolution magic angle spinning (HRMAS) nuclear magnetic resonance (NMR) spectroscopy to study 36 human serum samples collected from primary lung adenocarcinoma patients with or without AD, or AD and related dementia (ADRD). We identified 88 metabolites with 66 metabolites differentiating LC patients from controls, and 80 metabolites discerning LC patients without ADRD from those with ADRD. Our results demonstrate the capability of metabolomics to reveal inversely dysregulated glycolysis, oxidative phosphorylation, and proline metabolism in LC and ADRD.
Related Topics
Concepts
No concepts available.
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/nbm.70186
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/nbm.70186
- OA Status
- bronze
- References
- 54
- OpenAlex ID
- https://openalex.org/W4416843206
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4416843206Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1002/nbm.70186Digital Object Identifier
- Title
-
Metabolomic Relationships Between Lung Cancer and Alzheimer's Disease Using Serum Nuclear Magnetic Resonance SpectroscopyWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-11-30Full publication date if available
- Authors
-
Zuzanna Kobus, Marta Kobus, Ella Zhang, Rajshree Ghosh Biswas, J. Chen, Piet Habbel, Johannes Nowak, Li Su, David Kaul, Steven E. ArnoldList of authors in order
- Landing page
-
https://doi.org/10.1002/nbm.70186Publisher landing page
- PDF URL
-
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/nbm.70186Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
bronzeOpen access status per OpenAlex
- OA URL
-
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/nbm.70186Direct OA link when available
- Cited by
-
0Total citation count in OpenAlex
- References (count)
-
54Number of works referenced by this work
Full payload
| id | https://openalex.org/W4416843206 |
|---|---|
| doi | https://doi.org/10.1002/nbm.70186 |
| ids.doi | https://doi.org/10.1002/nbm.70186 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/41321042 |
| ids.openalex | https://openalex.org/W4416843206 |
| fwci | |
| mesh[0].qualifier_ui | |
| mesh[0].descriptor_ui | D006801 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | |
| mesh[0].descriptor_name | Humans |
| mesh[1].qualifier_ui | Q000097 |
| mesh[1].descriptor_ui | D000544 |
| mesh[1].is_major_topic | True |
| mesh[1].qualifier_name | blood |
| mesh[1].descriptor_name | Alzheimer Disease |
| mesh[2].qualifier_ui | Q000378 |
| mesh[2].descriptor_ui | D000544 |
| mesh[2].is_major_topic | True |
| mesh[2].qualifier_name | metabolism |
| mesh[2].descriptor_name | Alzheimer Disease |
| mesh[3].qualifier_ui | Q000097 |
| mesh[3].descriptor_ui | D008175 |
| mesh[3].is_major_topic | True |
| mesh[3].qualifier_name | blood |
| mesh[3].descriptor_name | Lung Neoplasms |
| mesh[4].qualifier_ui | Q000378 |
| mesh[4].descriptor_ui | D008175 |
| mesh[4].is_major_topic | True |
| mesh[4].qualifier_name | metabolism |
| mesh[4].descriptor_name | Lung Neoplasms |
| mesh[5].qualifier_ui | Q000379 |
| mesh[5].descriptor_ui | D055432 |
| mesh[5].is_major_topic | True |
| mesh[5].qualifier_name | methods |
| mesh[5].descriptor_name | Metabolomics |
| mesh[6].qualifier_ui | |
| mesh[6].descriptor_ui | D008297 |
| mesh[6].is_major_topic | False |
| mesh[6].qualifier_name | |
| mesh[6].descriptor_name | Male |
| mesh[7].qualifier_ui | |
| mesh[7].descriptor_ui | D005260 |
| mesh[7].is_major_topic | False |
| mesh[7].qualifier_name | |
| mesh[7].descriptor_name | Female |
| mesh[8].qualifier_ui | |
| mesh[8].descriptor_ui | D000368 |
| mesh[8].is_major_topic | False |
| mesh[8].qualifier_name | |
| mesh[8].descriptor_name | Aged |
| mesh[9].qualifier_ui | Q000379 |
| mesh[9].descriptor_ui | D009682 |
| mesh[9].is_major_topic | False |
| mesh[9].qualifier_name | methods |
| mesh[9].descriptor_name | Magnetic Resonance Spectroscopy |
| mesh[10].qualifier_ui | |
| mesh[10].descriptor_ui | D008875 |
| mesh[10].is_major_topic | False |
| mesh[10].qualifier_name | |
| mesh[10].descriptor_name | Middle Aged |
| mesh[11].qualifier_ui | |
| mesh[11].descriptor_ui | D055442 |
| mesh[11].is_major_topic | True |
| mesh[11].qualifier_name | |
| mesh[11].descriptor_name | Metabolome |
| mesh[12].qualifier_ui | |
| mesh[12].descriptor_ui | D000369 |
| mesh[12].is_major_topic | False |
| mesh[12].qualifier_name | |
| mesh[12].descriptor_name | Aged, 80 and over |
| type | article |
| title | Metabolomic Relationships Between Lung Cancer and Alzheimer's Disease Using Serum Nuclear Magnetic Resonance Spectroscopy |
| biblio.issue | 1 |
| biblio.volume | 39 |
| biblio.last_page | e70186 |
| biblio.first_page | e70186 |
| is_xpac | False |
| apc_list.value | 5150 |
| apc_list.currency | USD |
| apc_list.value_usd | 5150 |
| apc_paid | |
| language | en |
| locations[0].id | doi:10.1002/nbm.70186 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S45012897 |
| locations[0].source.issn | 0952-3480, 1099-1492 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | 0952-3480 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | NMR in Biomedicine |
| locations[0].source.host_organization | https://openalex.org/P4310320595 |
| locations[0].source.host_organization_name | Wiley |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310320595 |
| locations[0].source.host_organization_lineage_names | Wiley |
| locations[0].license | |
| locations[0].pdf_url | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/nbm.70186 |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | NMR in Biomedicine |
| locations[0].landing_page_url | https://doi.org/10.1002/nbm.70186 |
| locations[1].id | pmid:41321042 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | NMR in biomedicine |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/41321042 |
| indexed_in | crossref, pubmed |
| authorships[0].author.id | https://openalex.org/A5062168065 |
| authorships[0].author.orcid | |
| authorships[0].author.display_name | Zuzanna Kobus |
| authorships[0].countries | DE, US |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I7877124 |
| authorships[0].affiliations[0].raw_affiliation_string | Charité–Universitätsmedizin Berlin Berlin Germany |
| authorships[0].affiliations[1].institution_ids | https://openalex.org/I136199984, https://openalex.org/I4210087915 |
| authorships[0].affiliations[1].raw_affiliation_string | Departments of Radiology and Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA |
| authorships[0].institutions[0].id | https://openalex.org/I7877124 |
| authorships[0].institutions[0].ror | https://ror.org/001w7jn25 |
| authorships[0].institutions[0].type | healthcare |
| authorships[0].institutions[0].lineage | https://openalex.org/I7877124 |
| authorships[0].institutions[0].country_code | DE |
| authorships[0].institutions[0].display_name | Charité - Universitätsmedizin Berlin |
| authorships[0].institutions[1].id | https://openalex.org/I136199984 |
| authorships[0].institutions[1].ror | https://ror.org/03vek6s52 |
| authorships[0].institutions[1].type | education |
| authorships[0].institutions[1].lineage | https://openalex.org/I136199984 |
| authorships[0].institutions[1].country_code | US |
| authorships[0].institutions[1].display_name | Harvard University |
| authorships[0].institutions[2].id | https://openalex.org/I4210087915 |
| authorships[0].institutions[2].ror | https://ror.org/002pd6e78 |
| authorships[0].institutions[2].type | healthcare |
| authorships[0].institutions[2].lineage | https://openalex.org/I4210087915, https://openalex.org/I48633490 |
| authorships[0].institutions[2].country_code | US |
| authorships[0].institutions[2].display_name | Massachusetts General Hospital |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Zuzanna Kobus |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Charité–Universitätsmedizin Berlin Berlin Germany, Departments of Radiology and Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA |
| authorships[1].author.id | https://openalex.org/A5017941918 |
| authorships[1].author.orcid | https://orcid.org/0000-0002-1290-0626 |
| authorships[1].author.display_name | Marta Kobus |
| authorships[1].countries | DE, US |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I7877124 |
| authorships[1].affiliations[0].raw_affiliation_string | Department of Radiation Oncology Charité–Universitätsmedizin Berlin Berlin Germany |
| authorships[1].affiliations[1].institution_ids | https://openalex.org/I136199984, https://openalex.org/I4210087915 |
| authorships[1].affiliations[1].raw_affiliation_string | Departments of Radiology and Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA |
| authorships[1].institutions[0].id | https://openalex.org/I7877124 |
| authorships[1].institutions[0].ror | https://ror.org/001w7jn25 |
| authorships[1].institutions[0].type | healthcare |
| authorships[1].institutions[0].lineage | https://openalex.org/I7877124 |
| authorships[1].institutions[0].country_code | DE |
| authorships[1].institutions[0].display_name | Charité - Universitätsmedizin Berlin |
| authorships[1].institutions[1].id | https://openalex.org/I136199984 |
| authorships[1].institutions[1].ror | https://ror.org/03vek6s52 |
| authorships[1].institutions[1].type | education |
| authorships[1].institutions[1].lineage | https://openalex.org/I136199984 |
| authorships[1].institutions[1].country_code | US |
| authorships[1].institutions[1].display_name | Harvard University |
| authorships[1].institutions[2].id | https://openalex.org/I4210087915 |
| authorships[1].institutions[2].ror | https://ror.org/002pd6e78 |
| authorships[1].institutions[2].type | healthcare |
| authorships[1].institutions[2].lineage | https://openalex.org/I4210087915, https://openalex.org/I48633490 |
| authorships[1].institutions[2].country_code | US |
| authorships[1].institutions[2].display_name | Massachusetts General Hospital |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Marta Kobus |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Department of Radiation Oncology Charité–Universitätsmedizin Berlin Berlin Germany, Departments of Radiology and Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA |
| authorships[2].author.id | https://openalex.org/A5003952158 |
| authorships[2].author.orcid | https://orcid.org/0009-0001-3102-3788 |
| authorships[2].author.display_name | Ella Zhang |
| authorships[2].countries | US |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I136199984, https://openalex.org/I4210087915 |
| authorships[2].affiliations[0].raw_affiliation_string | Departments of Radiology and Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA |
| authorships[2].institutions[0].id | https://openalex.org/I136199984 |
| authorships[2].institutions[0].ror | https://ror.org/03vek6s52 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I136199984 |
| authorships[2].institutions[0].country_code | US |
| authorships[2].institutions[0].display_name | Harvard University |
| authorships[2].institutions[1].id | https://openalex.org/I4210087915 |
| authorships[2].institutions[1].ror | https://ror.org/002pd6e78 |
| authorships[2].institutions[1].type | healthcare |
| authorships[2].institutions[1].lineage | https://openalex.org/I4210087915, https://openalex.org/I48633490 |
| authorships[2].institutions[1].country_code | US |
| authorships[2].institutions[1].display_name | Massachusetts General Hospital |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Ella J. Zhang |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Departments of Radiology and Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA |
| authorships[3].author.id | https://openalex.org/A5084191299 |
| authorships[3].author.orcid | https://orcid.org/0000-0001-9967-6868 |
| authorships[3].author.display_name | Rajshree Ghosh Biswas |
| authorships[3].countries | US |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I136199984, https://openalex.org/I4210087915 |
| authorships[3].affiliations[0].raw_affiliation_string | Departments of Radiology and Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA |
| authorships[3].institutions[0].id | https://openalex.org/I136199984 |
| authorships[3].institutions[0].ror | https://ror.org/03vek6s52 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I136199984 |
| authorships[3].institutions[0].country_code | US |
| authorships[3].institutions[0].display_name | Harvard University |
| authorships[3].institutions[1].id | https://openalex.org/I4210087915 |
| authorships[3].institutions[1].ror | https://ror.org/002pd6e78 |
| authorships[3].institutions[1].type | healthcare |
| authorships[3].institutions[1].lineage | https://openalex.org/I4210087915, https://openalex.org/I48633490 |
| authorships[3].institutions[1].country_code | US |
| authorships[3].institutions[1].display_name | Massachusetts General Hospital |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Rajshree Ghosh Biswas |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Departments of Radiology and Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA |
| authorships[4].author.id | https://openalex.org/A5102888159 |
| authorships[4].author.orcid | https://orcid.org/0009-0003-2596-0243 |
| authorships[4].author.display_name | J. Chen |
| authorships[4].countries | US |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I136199984, https://openalex.org/I4210087915 |
| authorships[4].affiliations[0].raw_affiliation_string | Departments of Radiology and Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA |
| authorships[4].institutions[0].id | https://openalex.org/I136199984 |
| authorships[4].institutions[0].ror | https://ror.org/03vek6s52 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I136199984 |
| authorships[4].institutions[0].country_code | US |
| authorships[4].institutions[0].display_name | Harvard University |
| authorships[4].institutions[1].id | https://openalex.org/I4210087915 |
| authorships[4].institutions[1].ror | https://ror.org/002pd6e78 |
| authorships[4].institutions[1].type | healthcare |
| authorships[4].institutions[1].lineage | https://openalex.org/I4210087915, https://openalex.org/I48633490 |
| authorships[4].institutions[1].country_code | US |
| authorships[4].institutions[1].display_name | Massachusetts General Hospital |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Jiashang Chen |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Departments of Radiology and Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA |
| authorships[5].author.id | https://openalex.org/A5001916153 |
| authorships[5].author.orcid | |
| authorships[5].author.display_name | Piet Habbel |
| authorships[5].countries | DE |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I7877124 |
| authorships[5].affiliations[0].raw_affiliation_string | Charité–Universitätsmedizin Berlin Berlin Germany |
| authorships[5].institutions[0].id | https://openalex.org/I7877124 |
| authorships[5].institutions[0].ror | https://ror.org/001w7jn25 |
| authorships[5].institutions[0].type | healthcare |
| authorships[5].institutions[0].lineage | https://openalex.org/I7877124 |
| authorships[5].institutions[0].country_code | DE |
| authorships[5].institutions[0].display_name | Charité - Universitätsmedizin Berlin |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Piet Habbel |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Charité–Universitätsmedizin Berlin Berlin Germany |
| authorships[6].author.id | https://openalex.org/A5048275580 |
| authorships[6].author.orcid | https://orcid.org/0000-0002-3595-8951 |
| authorships[6].author.display_name | Johannes Nowak |
| authorships[6].countries | DE |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I4210114296 |
| authorships[6].affiliations[0].raw_affiliation_string | SRH University of Applied Health Sciences, Gera, Germany |
| authorships[6].affiliations[1].raw_affiliation_string | SRH Poliklinik Gera GmbH, Radiology Gotha, Gotha, Germany |
| authorships[6].institutions[0].id | https://openalex.org/I4210114296 |
| authorships[6].institutions[0].ror | https://ror.org/026kenw55 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I4210114296 |
| authorships[6].institutions[0].country_code | DE |
| authorships[6].institutions[0].display_name | SRH Hochschule für Gesundheit Gera |
| authorships[6].author_position | last |
| authorships[6].raw_author_name | Johannes Nowak |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | SRH Poliklinik Gera GmbH, Radiology Gotha, Gotha, Germany, SRH University of Applied Health Sciences, Gera, Germany |
| authorships[7].author.id | https://openalex.org/A5100374887 |
| authorships[7].author.orcid | https://orcid.org/0000-0002-5990-8457 |
| authorships[7].author.display_name | Li Su |
| authorships[7].countries | US |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I136199984 |
| authorships[7].affiliations[0].raw_affiliation_string | Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA |
| authorships[7].institutions[0].id | https://openalex.org/I136199984 |
| authorships[7].institutions[0].ror | https://ror.org/03vek6s52 |
| authorships[7].institutions[0].type | education |
| authorships[7].institutions[0].lineage | https://openalex.org/I136199984 |
| authorships[7].institutions[0].country_code | US |
| authorships[7].institutions[0].display_name | Harvard University |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Li Su |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA |
| authorships[8].author.id | https://openalex.org/A5005948038 |
| authorships[8].author.orcid | https://orcid.org/0000-0002-7906-5629 |
| authorships[8].author.display_name | David Kaul |
| authorships[8].countries | DE |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I7877124 |
| authorships[8].affiliations[0].raw_affiliation_string | Department of Radiation Oncology Charité–Universitätsmedizin Berlin Berlin Germany |
| authorships[8].institutions[0].id | https://openalex.org/I7877124 |
| authorships[8].institutions[0].ror | https://ror.org/001w7jn25 |
| authorships[8].institutions[0].type | healthcare |
| authorships[8].institutions[0].lineage | https://openalex.org/I7877124 |
| authorships[8].institutions[0].country_code | DE |
| authorships[8].institutions[0].display_name | Charité - Universitätsmedizin Berlin |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | David P. Kaul |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Department of Radiation Oncology Charité–Universitätsmedizin Berlin Berlin Germany |
| authorships[9].author.id | https://openalex.org/A5088881304 |
| authorships[9].author.orcid | https://orcid.org/0000-0002-9487-415X |
| authorships[9].author.display_name | Steven E. Arnold |
| authorships[9].countries | US |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I136199984, https://openalex.org/I4210087915 |
| authorships[9].affiliations[0].raw_affiliation_string | Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA |
| authorships[9].institutions[0].id | https://openalex.org/I136199984 |
| authorships[9].institutions[0].ror | https://ror.org/03vek6s52 |
| authorships[9].institutions[0].type | education |
| authorships[9].institutions[0].lineage | https://openalex.org/I136199984 |
| authorships[9].institutions[0].country_code | US |
| authorships[9].institutions[0].display_name | Harvard University |
| authorships[9].institutions[1].id | https://openalex.org/I4210087915 |
| authorships[9].institutions[1].ror | https://ror.org/002pd6e78 |
| authorships[9].institutions[1].type | healthcare |
| authorships[9].institutions[1].lineage | https://openalex.org/I4210087915, https://openalex.org/I48633490 |
| authorships[9].institutions[1].country_code | US |
| authorships[9].institutions[1].display_name | Massachusetts General Hospital |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Steven E. Arnold |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA |
| has_content.pdf | True |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/nbm.70186 |
| open_access.oa_status | bronze |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-12-01T00:00:00 |
| display_name | Metabolomic Relationships Between Lung Cancer and Alzheimer's Disease Using Serum Nuclear Magnetic Resonance Spectroscopy |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-12-03T00:04:00.142953 |
| primary_topic | |
| cited_by_count | 0 |
| locations_count | 2 |
| best_oa_location.id | doi:10.1002/nbm.70186 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S45012897 |
| best_oa_location.source.issn | 0952-3480, 1099-1492 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | 0952-3480 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | NMR in Biomedicine |
| best_oa_location.source.host_organization | https://openalex.org/P4310320595 |
| best_oa_location.source.host_organization_name | Wiley |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310320595 |
| best_oa_location.source.host_organization_lineage_names | Wiley |
| best_oa_location.license | |
| best_oa_location.pdf_url | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/nbm.70186 |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | NMR in Biomedicine |
| best_oa_location.landing_page_url | https://doi.org/10.1002/nbm.70186 |
| primary_location.id | doi:10.1002/nbm.70186 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S45012897 |
| primary_location.source.issn | 0952-3480, 1099-1492 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | 0952-3480 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | NMR in Biomedicine |
| primary_location.source.host_organization | https://openalex.org/P4310320595 |
| primary_location.source.host_organization_name | Wiley |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310320595 |
| primary_location.source.host_organization_lineage_names | Wiley |
| primary_location.license | |
| primary_location.pdf_url | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/nbm.70186 |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | NMR in Biomedicine |
| primary_location.landing_page_url | https://doi.org/10.1002/nbm.70186 |
| publication_date | 2025-11-30 |
| publication_year | 2025 |
| referenced_works | https://openalex.org/W3151068974, https://openalex.org/W2056631765, https://openalex.org/W2062361320, https://openalex.org/W2024996996, https://openalex.org/W2155636825, https://openalex.org/W2081707673, https://openalex.org/W2655375924, https://openalex.org/W3003258168, https://openalex.org/W2912346537, https://openalex.org/W2892608560, https://openalex.org/W2996690250, https://openalex.org/W2054172272, https://openalex.org/W2300111670, https://openalex.org/W3167562979, https://openalex.org/W4367296155, https://openalex.org/W2795705603, https://openalex.org/W2539494034, https://openalex.org/W2234115940, https://openalex.org/W2600906879, https://openalex.org/W4213109334, https://openalex.org/W4200109539, https://openalex.org/W2959503021, https://openalex.org/W4413897127, https://openalex.org/W2281516445, https://openalex.org/W2575711245, https://openalex.org/W4390201816, https://openalex.org/W2097259163, https://openalex.org/W3095894610, https://openalex.org/W2001791532, https://openalex.org/W2140303531, https://openalex.org/W200541223, https://openalex.org/W2765164306, https://openalex.org/W4389832363, https://openalex.org/W4408570447, https://openalex.org/W3125104082, https://openalex.org/W2971770812, https://openalex.org/W3188156707, https://openalex.org/W3024398531, https://openalex.org/W2907174268, https://openalex.org/W4391740614, https://openalex.org/W2009015096, https://openalex.org/W1997072841, https://openalex.org/W1976713658, https://openalex.org/W2463654601, https://openalex.org/W3122590747, https://openalex.org/W2985906564, https://openalex.org/W2108195113, https://openalex.org/W2625767007, https://openalex.org/W4205722329, https://openalex.org/W4310490263, https://openalex.org/W2923046924, https://openalex.org/W2325598884, https://openalex.org/W3093059812, https://openalex.org/W2051522090 |
| referenced_works_count | 54 |
| abstract_inverted_index.a | 20, 63 |
| abstract_inverted_index.36 | 95 |
| abstract_inverted_index.66 | 120 |
| abstract_inverted_index.80 | 128 |
| abstract_inverted_index.88 | 117 |
| abstract_inverted_index.AD | 27, 110 |
| abstract_inverted_index.LC | 25, 58, 123, 131, 157 |
| abstract_inverted_index.We | 115 |
| abstract_inverted_index.as | 62 |
| abstract_inverted_index.in | 156 |
| abstract_inverted_index.of | 15, 41, 53, 66, 144 |
| abstract_inverted_index.or | 106, 109 |
| abstract_inverted_index.to | 74, 93, 146 |
| abstract_inverted_index.we | 81 |
| abstract_inverted_index.AD, | 108 |
| abstract_inverted_index.AD. | 60 |
| abstract_inverted_index.Our | 139 |
| abstract_inverted_index.and | 4, 26, 44, 59, 111, 127, 153, 158 |
| abstract_inverted_index.are | 8 |
| abstract_inverted_index.for | 56 |
| abstract_inverted_index.has | 71 |
| abstract_inverted_index.may | 49 |
| abstract_inverted_index.not | 35 |
| abstract_inverted_index.the | 51, 67, 72, 142 |
| abstract_inverted_index.(AD) | 7 |
| abstract_inverted_index.(LC) | 3 |
| abstract_inverted_index.ADRD | 134 |
| abstract_inverted_index.Lung | 1 |
| abstract_inverted_index.been | 36 |
| abstract_inverted_index.both | 9, 42, 57 |
| abstract_inverted_index.from | 100, 125, 135 |
| abstract_inverted_index.have | 18, 34 |
| abstract_inverted_index.high | 13 |
| abstract_inverted_index.into | 76 |
| abstract_inverted_index.lung | 102 |
| abstract_inverted_index.used | 82 |
| abstract_inverted_index.well | 37 |
| abstract_inverted_index.with | 12, 105, 119, 137 |
| abstract_inverted_index.(NMR) | 91 |
| abstract_inverted_index.ADRD. | 138, 159 |
| abstract_inverted_index.angle | 85 |
| abstract_inverted_index.human | 96 |
| abstract_inverted_index.magic | 84 |
| abstract_inverted_index.probe | 75 |
| abstract_inverted_index.rates | 14 |
| abstract_inverted_index.serum | 97 |
| abstract_inverted_index.study | 65, 94 |
| abstract_inverted_index.their | 45, 77 |
| abstract_inverted_index.those | 136 |
| abstract_inverted_index.Better | 39 |
| abstract_inverted_index.cancer | 2 |
| abstract_inverted_index.entire | 68 |
| abstract_inverted_index.reveal | 147 |
| abstract_inverted_index.shared | 31 |
| abstract_inverted_index.(ADRD). | 114 |
| abstract_inverted_index.(HRMAS) | 87 |
| abstract_inverted_index.Herein, | 80 |
| abstract_inverted_index.Studies | 17 |
| abstract_inverted_index.advance | 50 |
| abstract_inverted_index.between | 24 |
| abstract_inverted_index.disease | 6 |
| abstract_inverted_index.inverse | 22 |
| abstract_inverted_index.nuclear | 88 |
| abstract_inverted_index.primary | 101 |
| abstract_inverted_index.proline | 154 |
| abstract_inverted_index.related | 112 |
| abstract_inverted_index.results | 140 |
| abstract_inverted_index.samples | 98 |
| abstract_inverted_index.without | 107, 133 |
| abstract_inverted_index.ABSTRACT | 0 |
| abstract_inverted_index.dementia | 113 |
| abstract_inverted_index.diseases | 11, 43 |
| abstract_inverted_index.holistic | 64 |
| abstract_inverted_index.however, | 29 |
| abstract_inverted_index.magnetic | 89 |
| abstract_inverted_index.patients | 104, 124, 132 |
| abstract_inverted_index.possible | 21, 30 |
| abstract_inverted_index.reported | 19 |
| abstract_inverted_index.spinning | 86 |
| abstract_inverted_index.collected | 99 |
| abstract_inverted_index.controls, | 126 |
| abstract_inverted_index.inversely | 148 |
| abstract_inverted_index.metabolic | 78 |
| abstract_inverted_index.molecular | 32, 47 |
| abstract_inverted_index.oxidative | 151 |
| abstract_inverted_index.potential | 46, 73 |
| abstract_inverted_index.resonance | 90 |
| abstract_inverted_index.therapies | 55 |
| abstract_inverted_index.capability | 143 |
| abstract_inverted_index.discerning | 130 |
| abstract_inverted_index.identified | 116 |
| abstract_inverted_index.measurable | 69 |
| abstract_inverted_index.mechanisms | 33 |
| abstract_inverted_index.metabolism | 155 |
| abstract_inverted_index.mortality. | 16 |
| abstract_inverted_index.successful | 54 |
| abstract_inverted_index.Alzheimer's | 5 |
| abstract_inverted_index.demonstrate | 141 |
| abstract_inverted_index.development | 52 |
| abstract_inverted_index.glycolysis, | 150 |
| abstract_inverted_index.incidences; | 28 |
| abstract_inverted_index.metabolites | 118, 121, 129 |
| abstract_inverted_index.metabolome, | 70 |
| abstract_inverted_index.connections. | 79 |
| abstract_inverted_index.dysregulated | 149 |
| abstract_inverted_index.metabolomics | 145 |
| abstract_inverted_index.relationship | 23 |
| abstract_inverted_index.spectroscopy | 92 |
| abstract_inverted_index.Metabolomics, | 61 |
| abstract_inverted_index.investigated. | 38 |
| abstract_inverted_index.relationships | 48 |
| abstract_inverted_index.adenocarcinoma | 103 |
| abstract_inverted_index.differentiating | 122 |
| abstract_inverted_index.age‐associated | 10 |
| abstract_inverted_index.phosphorylation, | 152 |
| abstract_inverted_index.characterizations | 40 |
| abstract_inverted_index.high‐resolution | 83 |
| cited_by_percentile_year | |
| countries_distinct_count | 2 |
| institutions_distinct_count | 10 |
| citation_normalized_percentile |