Metabolomics of Plasma in XLH Patients with Arterial Hypertension: New Insights into the Underlying Mechanisms Article Swipe
Luis Carlos López-Romero
,
José Jesús Broseta
,
Marta Roca
,
Juan R. Muñoz‐Castañeda
,
Agustín Lahoz
,
Julio Hernández Jaras
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/ijms25063545
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/ijms25063545
X-linked hypophosphatemia (XLH) is a rare genetic disorder that increases fibroblast growth factor 23 (FGF23). XLH patients have an elevated risk of early-onset hypertension. The precise factors contributing to hypertension in XLH patients have yet to be identified. A multicenter cross-sectional study of adult patients diagnosed with XLH. Metabolomic analysis was performed using ultra-performance liquid chromatography (UPLC) coupled to a high-resolution mass spectrometer. Twenty subjects were included, of which nine (45%) had hypertension. The median age was 44 years. Out of the total, seven (35%) subjects had a family history of hypertension. No statistically significant differences were found between both groups for nephrocalcinosis or hyperparathyroidism. Those with hypertension exhibited significantly higher levels of creatinine (1.08 ± 0.31 mg/dL vs. 0.78 ± 0.19 mg/dL; p = 0.01) and LDL-C (133.33 ± 21.92 mg/dL vs. 107.27 ± 20.12 mg/dL, p = 0.01). A total of 106 metabolites were identified. Acetylcarnitine (p = 0.03), pyruvate p = (0.04), ethanolamine (p = 0.03), and butyric acid (p = 0.001) were significantly different between both groups. This study is the first to examine the metabolomics of hypertension in patients with XLH. We have identified significant changes in specific metabolites that shed new light on the potential mechanisms of hypertension in XLH patients. These findings could lead to new studies identifying associated biomarkers and developing new diagnostic approaches for XLH patients.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/ijms25063545
- https://www.mdpi.com/1422-0067/25/6/3545/pdf?version=1711016834
- OA Status
- gold
- Cited By
- 3
- References
- 37
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4393044502
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4393044502Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/ijms25063545Digital Object Identifier
- Title
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Metabolomics of Plasma in XLH Patients with Arterial Hypertension: New Insights into the Underlying MechanismsWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
-
2024-03-21Full publication date if available
- Authors
-
Luis Carlos López-Romero, José Jesús Broseta, Marta Roca, Juan R. Muñoz‐Castañeda, Agustín Lahoz, Julio Hernández JarasList of authors in order
- Landing page
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https://doi.org/10.3390/ijms25063545Publisher landing page
- PDF URL
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https://www.mdpi.com/1422-0067/25/6/3545/pdf?version=1711016834Direct link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
- OA URL
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https://www.mdpi.com/1422-0067/25/6/3545/pdf?version=1711016834Direct OA link when available
- Concepts
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Internal medicine, Medicine, Endocrinology, Hypophosphatemia, Creatinine, GastroenterologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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3Total citation count in OpenAlex
- Citations by year (recent)
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2025: 1, 2024: 2Per-year citation counts (last 5 years)
- References (count)
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37Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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