Metabolomics profiling in acute liver transplant rejection in a pediatric population Article Swipe
Jennifer K. Frediani
,
Yara S. Beyh
,
Nitika Gupta
,
Adrianna Westbrook
,
Rebecca Cleeton
,
María Cordero
,
Albert Hernández
,
ViLinh Tran
,
Dean P. Jones
,
Miriam B. Vos
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1038/s41598-022-18957-4
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1038/s41598-022-18957-4
Pediatric liver transplantation rejection affects 20% of children. Currently, liver biopsy, expensive and invasive, is the best method of diagnosis. Discovery and validation of clinical biomarkers from blood or other biospecimens would improve clinical care. For this study, stored plasma samples were utilized from two cross-sectional cohorts of liver transplant patients at Children’s Healthcare of Atlanta. High resolution metabolic profiling was completed using established methods. Children with (n = 18) or without (n = 25) acute cellular rejection were included in the analysis (n = 43 total). The mean age of these racially diverse cohorts ranged from 12.6 years in the rejection group and 13.6 years in the no rejection group. Linear regression provided 510 significantly differentiating metabolites between groups, and OPLS-DA showed 145 metabolites with VIP > 2. A total of 95 overlapping significant metabolites between OPLS-DA and linear regression analyses were detected. Pathway analysis (p < 0.05) showed bile acid biosynthesis and tryptophan metabolism as the top two differentiating pathways. Network analysis also identified tryptophan and clustered with liver enzymes and steroid use. We conclude metabolic profiling of plasma from children with acute liver transplant rejection demonstrates > 500 significant metabolites. This result suggests that development of a non-invasive biomarker-based test is possible for rejection screening.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1038/s41598-022-18957-4
- https://www.nature.com/articles/s41598-022-18957-4.pdf
- OA Status
- gold
- Cited By
- 5
- References
- 33
- Related Works
- 10
- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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- DOI
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https://doi.org/10.1038/s41598-022-18957-4Digital Object Identifier
- Title
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Metabolomics profiling in acute liver transplant rejection in a pediatric populationWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
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2022-11-04Full publication date if available
- Authors
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Jennifer K. Frediani, Yara S. Beyh, Nitika Gupta, Adrianna Westbrook, Rebecca Cleeton, María Cordero, Albert Hernández, ViLinh Tran, Dean P. Jones, Miriam B. VosList of authors in order
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https://doi.org/10.1038/s41598-022-18957-4Publisher landing page
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https://www.nature.com/articles/s41598-022-18957-4.pdfDirect link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.nature.com/articles/s41598-022-18957-4.pdfDirect OA link when available
- Concepts
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Medicine, Liver transplantation, Metabolomics, Internal medicine, Transplantation, Population, Biomarker, Gastroenterology, Bioinformatics, Biology, Biochemistry, Environmental healthTop concepts (fields/topics) attached by OpenAlex
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5Total citation count in OpenAlex
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2025: 1, 2024: 3, 2023: 1Per-year citation counts (last 5 years)
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33Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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