Metagenomic detection of central nervous system infections missedby conventional testing Article Swipe
Noely Evangelista Ferreira
,
Michael G. Berg
,
Antônio Charlys da Costa
,
Mary A. Rodgers
,
Esper G. Kallás
,
Catarina Silveira
,
Mateus Vailant Thomazella
,
Ana Carolina Soares de Oliveira
,
Layla Honorato
,
Heuder Gustavo Oliveira Paião
,
Renán Barros Domingues
,
Carlos Senne
,
Marina Farrel Côrtes
,
Tânia Regina Tozetto‐Mendoza
,
Hélio Rodrigues Gomes
,
María Laura Matos
,
Gislaine Ribeiro Pereira
,
Steven S. Witkin
,
Gavin Cloherty
,
Maria Cássia Mendes-Corrêa
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1172/jci.insight.189295
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1172/jci.insight.189295
Community-acquired infectious meningoencephalitis is associated with high rates of mortality and morbidity, compounded by limited access to diagnostic resources. The current study assessed acute central nervous system (CNS) infections in patients with meningoencephalitis enrolled in a hospital-based diagnostic surveillance study in São Paulo, Brazil. Cerebrospinal fluid (CSF) was collected from 600 patients between March 2018 and November 2019 and initially screened for a broad range of pathogens according to a local diagnostic algorithm. Standard microbiological and molecular diagnostic methods were applied. Metagenomic sequencing was used as a complementary approach to investigating etiology in instances where no pathogen was initially identified. Standard testing identified infectious etiologies in 292 patients (48.6%), with 227 (77.7%) confirmed as viral infections, predominantly caused by enteroviruses (n = 144) and herpesviruses (n = 40). Nonviral agents were identified in 65 patients (22.3%). Metagenomic sequencing (mNGS) of 277 of 308 undiagnosed patients revealed several additional potential etiologies, including Parvovirus B19, Toxoplasma gondii, Picobirnavirus, other enterovirus species and Vesivirus, the latter being associated with CNS infection for the first time. These findings underscore the complexity of CNS infections and highlight the potential of metagenomics to improve diagnostic accuracy, inform treatment strategies, and support efforts to address future pandemics.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1172/jci.insight.189295
- http://insight.jci.org/articles/view/189295/files/pdf
- OA Status
- gold
- Cited By
- 1
- References
- 53
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4410531533
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4410531533Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1172/jci.insight.189295Digital Object Identifier
- Title
-
Metagenomic detection of central nervous system infections missedby conventional testingWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-05-20Full publication date if available
- Authors
-
Noely Evangelista Ferreira, Michael G. Berg, Antônio Charlys da Costa, Mary A. Rodgers, Esper G. Kallás, Catarina Silveira, Mateus Vailant Thomazella, Ana Carolina Soares de Oliveira, Layla Honorato, Heuder Gustavo Oliveira Paião, Renán Barros Domingues, Carlos Senne, Marina Farrel Côrtes, Tânia Regina Tozetto‐Mendoza, Hélio Rodrigues Gomes, María Laura Matos, Gislaine Ribeiro Pereira, Steven S. Witkin, Gavin Cloherty, Maria Cássia Mendes-CorrêaList of authors in order
- Landing page
-
https://doi.org/10.1172/jci.insight.189295Publisher landing page
- PDF URL
-
https://insight.jci.org/articles/view/189295/files/pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://insight.jci.org/articles/view/189295/files/pdfDirect OA link when available
- Concepts
-
Metagenomics, Central nervous system, Computational biology, Computer science, Medicine, Biology, Neuroscience, Biochemistry, GeneTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
1Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1Per-year citation counts (last 5 years)
- References (count)
-
53Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4410531533 |
|---|---|
| doi | https://doi.org/10.1172/jci.insight.189295 |
| ids.doi | https://doi.org/10.1172/jci.insight.189295 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/40392601 |
| ids.openalex | https://openalex.org/W4410531533 |
| fwci | 4.40320365 |
| mesh[0].qualifier_ui | |
| mesh[0].descriptor_ui | D006801 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | |
| mesh[0].descriptor_name | Humans |
| mesh[1].qualifier_ui | Q000379 |
| mesh[1].descriptor_ui | D056186 |
| mesh[1].is_major_topic | True |
| mesh[1].qualifier_name | methods |
| mesh[1].descriptor_name | Metagenomics |
| mesh[2].qualifier_ui | |
| mesh[2].descriptor_ui | D005260 |
| mesh[2].is_major_topic | False |
| mesh[2].qualifier_name | |
| mesh[2].descriptor_name | Female |
| mesh[3].qualifier_ui | |
| mesh[3].descriptor_ui | D008297 |
| mesh[3].is_major_topic | False |
| mesh[3].qualifier_name | |
| mesh[3].descriptor_name | Male |
| mesh[4].qualifier_ui | |
| mesh[4].descriptor_ui | D000328 |
| mesh[4].is_major_topic | False |
| mesh[4].qualifier_name | |
| mesh[4].descriptor_name | Adult |
| mesh[5].qualifier_ui | Q000175 |
| mesh[5].descriptor_ui | D002494 |
| mesh[5].is_major_topic | True |
| mesh[5].qualifier_name | diagnosis |
| mesh[5].descriptor_name | Central Nervous System Infections |
| mesh[6].qualifier_ui | Q000134 |
| mesh[6].descriptor_ui | D002494 |
| mesh[6].is_major_topic | True |
| mesh[6].qualifier_name | cerebrospinal fluid |
| mesh[6].descriptor_name | Central Nervous System Infections |
| mesh[7].qualifier_ui | Q000821 |
| mesh[7].descriptor_ui | D002494 |
| mesh[7].is_major_topic | True |
| mesh[7].qualifier_name | virology |
| mesh[7].descriptor_name | Central Nervous System Infections |
| mesh[8].qualifier_ui | |
| mesh[8].descriptor_ui | D008875 |
| mesh[8].is_major_topic | False |
| mesh[8].qualifier_name | |
| mesh[8].descriptor_name | Middle Aged |
| mesh[9].qualifier_ui | Q000453 |
| mesh[9].descriptor_ui | D001938 |
| mesh[9].is_major_topic | False |
| mesh[9].qualifier_name | epidemiology |
| mesh[9].descriptor_name | Brazil |
| mesh[10].qualifier_ui | |
| mesh[10].descriptor_ui | D000293 |
| mesh[10].is_major_topic | False |
| mesh[10].qualifier_name | |
| mesh[10].descriptor_name | Adolescent |
| mesh[11].qualifier_ui | |
| mesh[11].descriptor_ui | D002648 |
| mesh[11].is_major_topic | False |
| mesh[11].qualifier_name | |
| mesh[11].descriptor_name | Child |
| mesh[12].qualifier_ui | |
| mesh[12].descriptor_ui | D002675 |
| mesh[12].is_major_topic | False |
| mesh[12].qualifier_name | |
| mesh[12].descriptor_name | Child, Preschool |
| mesh[13].qualifier_ui | |
| mesh[13].descriptor_ui | D055815 |
| mesh[13].is_major_topic | False |
| mesh[13].qualifier_name | |
| mesh[13].descriptor_name | Young Adult |
| mesh[14].qualifier_ui | |
| mesh[14].descriptor_ui | D000368 |
| mesh[14].is_major_topic | False |
| mesh[14].qualifier_name | |
| mesh[14].descriptor_name | Aged |
| mesh[15].qualifier_ui | Q000175 |
| mesh[15].descriptor_ui | D008590 |
| mesh[15].is_major_topic | True |
| mesh[15].qualifier_name | diagnosis |
| mesh[15].descriptor_name | Meningoencephalitis |
| mesh[16].qualifier_ui | Q000134 |
| mesh[16].descriptor_ui | D008590 |
| mesh[16].is_major_topic | True |
| mesh[16].qualifier_name | cerebrospinal fluid |
| mesh[16].descriptor_name | Meningoencephalitis |
| mesh[17].qualifier_ui | Q000821 |
| mesh[17].descriptor_ui | D008590 |
| mesh[17].is_major_topic | True |
| mesh[17].qualifier_name | virology |
| mesh[17].descriptor_name | Meningoencephalitis |
| mesh[18].qualifier_ui | |
| mesh[18].descriptor_ui | D007223 |
| mesh[18].is_major_topic | False |
| mesh[18].qualifier_name | |
| mesh[18].descriptor_name | Infant |
| mesh[19].qualifier_ui | Q000235 |
| mesh[19].descriptor_ui | D004770 |
| mesh[19].is_major_topic | False |
| mesh[19].qualifier_name | genetics |
| mesh[19].descriptor_name | Enterovirus |
| mesh[20].qualifier_ui | Q000302 |
| mesh[20].descriptor_ui | D004770 |
| mesh[20].is_major_topic | False |
| mesh[20].qualifier_name | isolation & purification |
| mesh[20].descriptor_name | Enterovirus |
| mesh[21].qualifier_ui | Q000235 |
| mesh[21].descriptor_ui | D014122 |
| mesh[21].is_major_topic | False |
| mesh[21].qualifier_name | genetics |
| mesh[21].descriptor_name | Toxoplasma |
| mesh[22].qualifier_ui | Q000302 |
| mesh[22].descriptor_ui | D014122 |
| mesh[22].is_major_topic | False |
| mesh[22].qualifier_name | isolation & purification |
| mesh[22].descriptor_name | Toxoplasma |
| mesh[23].qualifier_ui | |
| mesh[23].descriptor_ui | D006801 |
| mesh[23].is_major_topic | False |
| mesh[23].qualifier_name | |
| mesh[23].descriptor_name | Humans |
| mesh[24].qualifier_ui | Q000379 |
| mesh[24].descriptor_ui | D056186 |
| mesh[24].is_major_topic | True |
| mesh[24].qualifier_name | methods |
| mesh[24].descriptor_name | Metagenomics |
| mesh[25].qualifier_ui | |
| mesh[25].descriptor_ui | D005260 |
| mesh[25].is_major_topic | False |
| mesh[25].qualifier_name | |
| mesh[25].descriptor_name | Female |
| mesh[26].qualifier_ui | |
| mesh[26].descriptor_ui | D008297 |
| mesh[26].is_major_topic | False |
| mesh[26].qualifier_name | |
| mesh[26].descriptor_name | Male |
| mesh[27].qualifier_ui | |
| mesh[27].descriptor_ui | D000328 |
| mesh[27].is_major_topic | False |
| mesh[27].qualifier_name | |
| mesh[27].descriptor_name | Adult |
| mesh[28].qualifier_ui | Q000175 |
| mesh[28].descriptor_ui | D002494 |
| mesh[28].is_major_topic | True |
| mesh[28].qualifier_name | diagnosis |
| mesh[28].descriptor_name | Central Nervous System Infections |
| mesh[29].qualifier_ui | Q000134 |
| mesh[29].descriptor_ui | D002494 |
| mesh[29].is_major_topic | True |
| mesh[29].qualifier_name | cerebrospinal fluid |
| mesh[29].descriptor_name | Central Nervous System Infections |
| mesh[30].qualifier_ui | Q000821 |
| mesh[30].descriptor_ui | D002494 |
| mesh[30].is_major_topic | True |
| mesh[30].qualifier_name | virology |
| mesh[30].descriptor_name | Central Nervous System Infections |
| mesh[31].qualifier_ui | |
| mesh[31].descriptor_ui | D008875 |
| mesh[31].is_major_topic | False |
| mesh[31].qualifier_name | |
| mesh[31].descriptor_name | Middle Aged |
| mesh[32].qualifier_ui | Q000453 |
| mesh[32].descriptor_ui | D001938 |
| mesh[32].is_major_topic | False |
| mesh[32].qualifier_name | epidemiology |
| mesh[32].descriptor_name | Brazil |
| mesh[33].qualifier_ui | |
| mesh[33].descriptor_ui | D000293 |
| mesh[33].is_major_topic | False |
| mesh[33].qualifier_name | |
| mesh[33].descriptor_name | Adolescent |
| mesh[34].qualifier_ui | |
| mesh[34].descriptor_ui | D002648 |
| mesh[34].is_major_topic | False |
| mesh[34].qualifier_name | |
| mesh[34].descriptor_name | Child |
| mesh[35].qualifier_ui | |
| mesh[35].descriptor_ui | D002675 |
| mesh[35].is_major_topic | False |
| mesh[35].qualifier_name | |
| mesh[35].descriptor_name | Child, Preschool |
| mesh[36].qualifier_ui | |
| mesh[36].descriptor_ui | D055815 |
| mesh[36].is_major_topic | False |
| mesh[36].qualifier_name | |
| mesh[36].descriptor_name | Young Adult |
| mesh[37].qualifier_ui | |
| mesh[37].descriptor_ui | D000368 |
| mesh[37].is_major_topic | False |
| mesh[37].qualifier_name | |
| mesh[37].descriptor_name | Aged |
| mesh[38].qualifier_ui | Q000175 |
| mesh[38].descriptor_ui | D008590 |
| mesh[38].is_major_topic | True |
| mesh[38].qualifier_name | diagnosis |
| mesh[38].descriptor_name | Meningoencephalitis |
| mesh[39].qualifier_ui | Q000134 |
| mesh[39].descriptor_ui | D008590 |
| mesh[39].is_major_topic | True |
| mesh[39].qualifier_name | cerebrospinal fluid |
| mesh[39].descriptor_name | Meningoencephalitis |
| mesh[40].qualifier_ui | Q000821 |
| mesh[40].descriptor_ui | D008590 |
| mesh[40].is_major_topic | True |
| mesh[40].qualifier_name | virology |
| mesh[40].descriptor_name | Meningoencephalitis |
| mesh[41].qualifier_ui | |
| mesh[41].descriptor_ui | D007223 |
| mesh[41].is_major_topic | False |
| mesh[41].qualifier_name | |
| mesh[41].descriptor_name | Infant |
| mesh[42].qualifier_ui | Q000235 |
| mesh[42].descriptor_ui | D004770 |
| mesh[42].is_major_topic | False |
| mesh[42].qualifier_name | genetics |
| mesh[42].descriptor_name | Enterovirus |
| mesh[43].qualifier_ui | Q000302 |
| mesh[43].descriptor_ui | D004770 |
| mesh[43].is_major_topic | False |
| mesh[43].qualifier_name | isolation & purification |
| mesh[43].descriptor_name | Enterovirus |
| mesh[44].qualifier_ui | Q000235 |
| mesh[44].descriptor_ui | D014122 |
| mesh[44].is_major_topic | False |
| mesh[44].qualifier_name | genetics |
| mesh[44].descriptor_name | Toxoplasma |
| mesh[45].qualifier_ui | Q000302 |
| mesh[45].descriptor_ui | D014122 |
| mesh[45].is_major_topic | False |
| mesh[45].qualifier_name | isolation & purification |
| mesh[45].descriptor_name | Toxoplasma |
| type | article |
| title | Metagenomic detection of central nervous system infections missedby conventional testing |
| biblio.issue | 13 |
| biblio.volume | 10 |
| biblio.last_page | |
| biblio.first_page | |
| topics[0].id | https://openalex.org/T13201 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 0.9660999774932861 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2725 |
| topics[0].subfield.display_name | Infectious Diseases |
| topics[0].display_name | Infectious Encephalopathies and Encephalitis |
| topics[1].id | https://openalex.org/T10873 |
| topics[1].field.id | https://openalex.org/fields/24 |
| topics[1].field.display_name | Immunology and Microbiology |
| topics[1].score | 0.9271000027656555 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2404 |
| topics[1].subfield.display_name | Microbiology |
| topics[1].display_name | Bacterial Infections and Vaccines |
| topics[2].id | https://openalex.org/T11316 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.9146999716758728 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2713 |
| topics[2].subfield.display_name | Epidemiology |
| topics[2].display_name | Mycobacterium research and diagnosis |
| is_xpac | False |
| apc_list.value | 4100 |
| apc_list.currency | USD |
| apc_list.value_usd | 4100 |
| apc_paid.value | 4100 |
| apc_paid.currency | USD |
| apc_paid.value_usd | 4100 |
| concepts[0].id | https://openalex.org/C15151743 |
| concepts[0].level | 3 |
| concepts[0].score | 0.6743850111961365 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q903778 |
| concepts[0].display_name | Metagenomics |
| concepts[1].id | https://openalex.org/C529278444 |
| concepts[1].level | 2 |
| concepts[1].score | 0.5186971426010132 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q47273 |
| concepts[1].display_name | Central nervous system |
| concepts[2].id | https://openalex.org/C70721500 |
| concepts[2].level | 1 |
| concepts[2].score | 0.39764440059661865 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q177005 |
| concepts[2].display_name | Computational biology |
| concepts[3].id | https://openalex.org/C41008148 |
| concepts[3].level | 0 |
| concepts[3].score | 0.39213860034942627 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q21198 |
| concepts[3].display_name | Computer science |
| concepts[4].id | https://openalex.org/C71924100 |
| concepts[4].level | 0 |
| concepts[4].score | 0.38540223240852356 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[4].display_name | Medicine |
| concepts[5].id | https://openalex.org/C86803240 |
| concepts[5].level | 0 |
| concepts[5].score | 0.36420077085494995 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[5].display_name | Biology |
| concepts[6].id | https://openalex.org/C169760540 |
| concepts[6].level | 1 |
| concepts[6].score | 0.3063420057296753 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q207011 |
| concepts[6].display_name | Neuroscience |
| concepts[7].id | https://openalex.org/C55493867 |
| concepts[7].level | 1 |
| concepts[7].score | 0.0 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q7094 |
| concepts[7].display_name | Biochemistry |
| concepts[8].id | https://openalex.org/C104317684 |
| concepts[8].level | 2 |
| concepts[8].score | 0.0 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q7187 |
| concepts[8].display_name | Gene |
| keywords[0].id | https://openalex.org/keywords/metagenomics |
| keywords[0].score | 0.6743850111961365 |
| keywords[0].display_name | Metagenomics |
| keywords[1].id | https://openalex.org/keywords/central-nervous-system |
| keywords[1].score | 0.5186971426010132 |
| keywords[1].display_name | Central nervous system |
| keywords[2].id | https://openalex.org/keywords/computational-biology |
| keywords[2].score | 0.39764440059661865 |
| keywords[2].display_name | Computational biology |
| keywords[3].id | https://openalex.org/keywords/computer-science |
| keywords[3].score | 0.39213860034942627 |
| keywords[3].display_name | Computer science |
| keywords[4].id | https://openalex.org/keywords/medicine |
| keywords[4].score | 0.38540223240852356 |
| keywords[4].display_name | Medicine |
| keywords[5].id | https://openalex.org/keywords/biology |
| keywords[5].score | 0.36420077085494995 |
| keywords[5].display_name | Biology |
| keywords[6].id | https://openalex.org/keywords/neuroscience |
| keywords[6].score | 0.3063420057296753 |
| keywords[6].display_name | Neuroscience |
| language | en |
| locations[0].id | doi:10.1172/jci.insight.189295 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S2764964142 |
| locations[0].source.issn | 2379-3708 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 2379-3708 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | JCI Insight |
| locations[0].source.host_organization | https://openalex.org/P4310320279 |
| locations[0].source.host_organization_name | American Society for Clinical Investigation |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310320279 |
| locations[0].source.host_organization_lineage_names | American Society for Clinical Investigation |
| locations[0].license | cc-by |
| locations[0].pdf_url | http://insight.jci.org/articles/view/189295/files/pdf |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | JCI Insight |
| locations[0].landing_page_url | https://doi.org/10.1172/jci.insight.189295 |
| locations[1].id | pmid:40392601 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | JCI insight |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/40392601 |
| locations[2].id | pmh:oai:pubmedcentral.nih.gov:12306619 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S2764455111 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | PubMed Central |
| locations[2].source.host_organization | https://openalex.org/I1299303238 |
| locations[2].source.host_organization_name | National Institutes of Health |
| locations[2].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[2].license | cc-by |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | https://openalex.org/licenses/cc-by |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | JCI Insight |
| locations[2].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/12306619 |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5103725026 |
| authorships[0].author.orcid | https://orcid.org/0000-0001-6041-5791 |
| authorships[0].author.display_name | Noely Evangelista Ferreira |
| authorships[0].countries | BR |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I4210145268 |
| authorships[0].affiliations[0].raw_affiliation_string | Departamento de Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil. |
| authorships[0].institutions[0].id | https://openalex.org/I4210145268 |
| authorships[0].institutions[0].ror | https://ror.org/03se9eg94 |
| authorships[0].institutions[0].type | healthcare |
| authorships[0].institutions[0].lineage | https://openalex.org/I4210145268 |
| authorships[0].institutions[0].country_code | BR |
| authorships[0].institutions[0].display_name | Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Noely Evangelista Ferreira |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Departamento de Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil. |
| authorships[1].author.id | https://openalex.org/A5062053457 |
| authorships[1].author.orcid | https://orcid.org/0000-0003-0233-5819 |
| authorships[1].author.display_name | Michael G. Berg |
| authorships[1].countries | US |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I4210142393 |
| authorships[1].affiliations[0].raw_affiliation_string | Infectious Diseases Research, Abbott Diagnostics, Abbott Park, United States of America. |
| authorships[1].institutions[0].id | https://openalex.org/I4210142393 |
| authorships[1].institutions[0].ror | https://ror.org/041w95745 |
| authorships[1].institutions[0].type | nonprofit |
| authorships[1].institutions[0].lineage | https://openalex.org/I4210142393 |
| authorships[1].institutions[0].country_code | US |
| authorships[1].institutions[0].display_name | Abbott Fund |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Michael G Berg |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Infectious Diseases Research, Abbott Diagnostics, Abbott Park, United States of America. |
| authorships[2].author.id | https://openalex.org/A5109910072 |
| authorships[2].author.orcid | https://orcid.org/0000-0001-5516-5177 |
| authorships[2].author.display_name | Antônio Charlys da Costa |
| authorships[2].countries | BR |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I4210145268 |
| authorships[2].affiliations[0].raw_affiliation_string | Departamento de Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil. |
| authorships[2].institutions[0].id | https://openalex.org/I4210145268 |
| authorships[2].institutions[0].ror | https://ror.org/03se9eg94 |
| authorships[2].institutions[0].type | healthcare |
| authorships[2].institutions[0].lineage | https://openalex.org/I4210145268 |
| authorships[2].institutions[0].country_code | BR |
| authorships[2].institutions[0].display_name | Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Antonio C da Costa |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Departamento de Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil. |
| authorships[3].author.id | https://openalex.org/A5033553191 |
| authorships[3].author.orcid | https://orcid.org/0000-0001-8815-8651 |
| authorships[3].author.display_name | Mary A. Rodgers |
| authorships[3].countries | US |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I4210142393 |
| authorships[3].affiliations[0].raw_affiliation_string | Infectious Diseases Research, Abbott Diagnostics, Abbott Park, United States of America. |
| authorships[3].institutions[0].id | https://openalex.org/I4210142393 |
| authorships[3].institutions[0].ror | https://ror.org/041w95745 |
| authorships[3].institutions[0].type | nonprofit |
| authorships[3].institutions[0].lineage | https://openalex.org/I4210142393 |
| authorships[3].institutions[0].country_code | US |
| authorships[3].institutions[0].display_name | Abbott Fund |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Mary A Rodgers |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Infectious Diseases Research, Abbott Diagnostics, Abbott Park, United States of America. |
| authorships[4].author.id | https://openalex.org/A5051400480 |
| authorships[4].author.orcid | https://orcid.org/0000-0003-2026-6925 |
| authorships[4].author.display_name | Esper G. Kallás |
| authorships[4].countries | BR |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I4210145268 |
| authorships[4].affiliations[0].raw_affiliation_string | Departamento de Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil. |
| authorships[4].institutions[0].id | https://openalex.org/I4210145268 |
| authorships[4].institutions[0].ror | https://ror.org/03se9eg94 |
| authorships[4].institutions[0].type | healthcare |
| authorships[4].institutions[0].lineage | https://openalex.org/I4210145268 |
| authorships[4].institutions[0].country_code | BR |
| authorships[4].institutions[0].display_name | Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Esper G Kallas |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Departamento de Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil. |
| authorships[5].author.id | https://openalex.org/A5053904257 |
| authorships[5].author.orcid | https://orcid.org/0000-0002-4693-1316 |
| authorships[5].author.display_name | Catarina Silveira |
| authorships[5].countries | BR |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I4210145268 |
| authorships[5].affiliations[0].raw_affiliation_string | Departamento de Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil. |
| authorships[5].institutions[0].id | https://openalex.org/I4210145268 |
| authorships[5].institutions[0].ror | https://ror.org/03se9eg94 |
| authorships[5].institutions[0].type | healthcare |
| authorships[5].institutions[0].lineage | https://openalex.org/I4210145268 |
| authorships[5].institutions[0].country_code | BR |
| authorships[5].institutions[0].display_name | Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Cassia G Terrasani Silveira |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Departamento de Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil. |
| authorships[6].author.id | https://openalex.org/A5050634198 |
| authorships[6].author.orcid | https://orcid.org/0000-0002-1527-6910 |
| authorships[6].author.display_name | Mateus Vailant Thomazella |
| authorships[6].countries | BR |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I4210145268 |
| authorships[6].affiliations[0].raw_affiliation_string | Departamento de Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil. |
| authorships[6].institutions[0].id | https://openalex.org/I4210145268 |
| authorships[6].institutions[0].ror | https://ror.org/03se9eg94 |
| authorships[6].institutions[0].type | healthcare |
| authorships[6].institutions[0].lineage | https://openalex.org/I4210145268 |
| authorships[6].institutions[0].country_code | BR |
| authorships[6].institutions[0].display_name | Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Mateus Vailant Thomazella |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Departamento de Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil. |
| authorships[7].author.id | https://openalex.org/A5008960930 |
| authorships[7].author.orcid | https://orcid.org/0000-0002-7406-6868 |
| authorships[7].author.display_name | Ana Carolina Soares de Oliveira |
| authorships[7].countries | BR |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I4210145268 |
| authorships[7].affiliations[0].raw_affiliation_string | Departamento de Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil. |
| authorships[7].institutions[0].id | https://openalex.org/I4210145268 |
| authorships[7].institutions[0].ror | https://ror.org/03se9eg94 |
| authorships[7].institutions[0].type | healthcare |
| authorships[7].institutions[0].lineage | https://openalex.org/I4210145268 |
| authorships[7].institutions[0].country_code | BR |
| authorships[7].institutions[0].display_name | Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Ana Carolina Soares de Oliveira |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Departamento de Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil. |
| authorships[8].author.id | https://openalex.org/A5089249787 |
| authorships[8].author.orcid | https://orcid.org/0000-0001-7084-3095 |
| authorships[8].author.display_name | Layla Honorato |
| authorships[8].countries | BR |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I4210145268 |
| authorships[8].affiliations[0].raw_affiliation_string | Departamento de Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil. |
| authorships[8].institutions[0].id | https://openalex.org/I4210145268 |
| authorships[8].institutions[0].ror | https://ror.org/03se9eg94 |
| authorships[8].institutions[0].type | healthcare |
| authorships[8].institutions[0].lineage | https://openalex.org/I4210145268 |
| authorships[8].institutions[0].country_code | BR |
| authorships[8].institutions[0].display_name | Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Layla Honorato |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Departamento de Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil. |
| authorships[9].author.id | https://openalex.org/A5048014435 |
| authorships[9].author.orcid | https://orcid.org/0000-0002-4358-1146 |
| authorships[9].author.display_name | Heuder Gustavo Oliveira Paião |
| authorships[9].countries | BR |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I4210145268 |
| authorships[9].affiliations[0].raw_affiliation_string | Departamento de Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil. |
| authorships[9].institutions[0].id | https://openalex.org/I4210145268 |
| authorships[9].institutions[0].ror | https://ror.org/03se9eg94 |
| authorships[9].institutions[0].type | healthcare |
| authorships[9].institutions[0].lineage | https://openalex.org/I4210145268 |
| authorships[9].institutions[0].country_code | BR |
| authorships[9].institutions[0].display_name | Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Heuder Go Paião |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | Departamento de Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil. |
| authorships[10].author.id | https://openalex.org/A5051857647 |
| authorships[10].author.orcid | https://orcid.org/0000-0002-6058-7937 |
| authorships[10].author.display_name | Renán Barros Domingues |
| authorships[10].affiliations[0].raw_affiliation_string | Senne Liquor Diagnóstico, São Paulo, Brazil. |
| authorships[10].author_position | middle |
| authorships[10].raw_author_name | Renan Barros Domingues |
| authorships[10].is_corresponding | False |
| authorships[10].raw_affiliation_strings | Senne Liquor Diagnóstico, São Paulo, Brazil. |
| authorships[11].author.id | https://openalex.org/A5031367836 |
| authorships[11].author.orcid | |
| authorships[11].author.display_name | Carlos Senne |
| authorships[11].affiliations[0].raw_affiliation_string | Senne Liquor Diagnóstico, São Paulo, Brazil. |
| authorships[11].author_position | middle |
| authorships[11].raw_author_name | Carlos Senne |
| authorships[11].is_corresponding | False |
| authorships[11].raw_affiliation_strings | Senne Liquor Diagnóstico, São Paulo, Brazil. |
| authorships[12].author.id | https://openalex.org/A5080246268 |
| authorships[12].author.orcid | https://orcid.org/0000-0003-1925-4855 |
| authorships[12].author.display_name | Marina Farrel Côrtes |
| authorships[12].countries | BR |
| authorships[12].affiliations[0].institution_ids | https://openalex.org/I4210145268 |
| authorships[12].affiliations[0].raw_affiliation_string | Departamento de Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil. |
| authorships[12].institutions[0].id | https://openalex.org/I4210145268 |
| authorships[12].institutions[0].ror | https://ror.org/03se9eg94 |
| authorships[12].institutions[0].type | healthcare |
| authorships[12].institutions[0].lineage | https://openalex.org/I4210145268 |
| authorships[12].institutions[0].country_code | BR |
| authorships[12].institutions[0].display_name | Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo |
| authorships[12].author_position | middle |
| authorships[12].raw_author_name | Marina F Côrtes |
| authorships[12].is_corresponding | False |
| authorships[12].raw_affiliation_strings | Departamento de Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil. |
| authorships[13].author.id | https://openalex.org/A5044267672 |
| authorships[13].author.orcid | https://orcid.org/0000-0002-5659-1052 |
| authorships[13].author.display_name | Tânia Regina Tozetto‐Mendoza |
| authorships[13].countries | BR |
| authorships[13].affiliations[0].institution_ids | https://openalex.org/I4210145268 |
| authorships[13].affiliations[0].raw_affiliation_string | Departamento de Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil. |
| authorships[13].institutions[0].id | https://openalex.org/I4210145268 |
| authorships[13].institutions[0].ror | https://ror.org/03se9eg94 |
| authorships[13].institutions[0].type | healthcare |
| authorships[13].institutions[0].lineage | https://openalex.org/I4210145268 |
| authorships[13].institutions[0].country_code | BR |
| authorships[13].institutions[0].display_name | Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo |
| authorships[13].author_position | middle |
| authorships[13].raw_author_name | Tania R Tozetto-Mendoza |
| authorships[13].is_corresponding | False |
| authorships[13].raw_affiliation_strings | Departamento de Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil. |
| authorships[14].author.id | https://openalex.org/A5082797985 |
| authorships[14].author.orcid | https://orcid.org/0000-0003-4461-0305 |
| authorships[14].author.display_name | Hélio Rodrigues Gomes |
| authorships[14].countries | BR |
| authorships[14].affiliations[0].institution_ids | https://openalex.org/I4210145268 |
| authorships[14].affiliations[0].raw_affiliation_string | Divisão Neurologia -Hospital das Clinicas da Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil. |
| authorships[14].institutions[0].id | https://openalex.org/I4210145268 |
| authorships[14].institutions[0].ror | https://ror.org/03se9eg94 |
| authorships[14].institutions[0].type | healthcare |
| authorships[14].institutions[0].lineage | https://openalex.org/I4210145268 |
| authorships[14].institutions[0].country_code | BR |
| authorships[14].institutions[0].display_name | Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo |
| authorships[14].author_position | middle |
| authorships[14].raw_author_name | Hélio R Gomes |
| authorships[14].is_corresponding | False |
| authorships[14].raw_affiliation_strings | Divisão Neurologia -Hospital das Clinicas da Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil. |
| authorships[15].author.id | https://openalex.org/A5102915125 |
| authorships[15].author.orcid | https://orcid.org/0000-0002-5296-3269 |
| authorships[15].author.display_name | María Laura Matos |
| authorships[15].countries | BR |
| authorships[15].affiliations[0].institution_ids | https://openalex.org/I156655148 |
| authorships[15].affiliations[0].raw_affiliation_string | Faculdade de Medicina, Universidade de São Caetano do Sul, São Paulo, Brazil. |
| authorships[15].institutions[0].id | https://openalex.org/I156655148 |
| authorships[15].institutions[0].ror | https://ror.org/00gby0d64 |
| authorships[15].institutions[0].type | education |
| authorships[15].institutions[0].lineage | https://openalex.org/I156655148 |
| authorships[15].institutions[0].country_code | BR |
| authorships[15].institutions[0].display_name | Universidade Municipal de São Caetano do Sul |
| authorships[15].author_position | middle |
| authorships[15].raw_author_name | Maria Laura Mariano Matos |
| authorships[15].is_corresponding | False |
| authorships[15].raw_affiliation_strings | Faculdade de Medicina, Universidade de São Caetano do Sul, São Paulo, Brazil. |
| authorships[16].author.id | https://openalex.org/A5071040572 |
| authorships[16].author.orcid | https://orcid.org/0000-0003-2293-7868 |
| authorships[16].author.display_name | Gislaine Ribeiro Pereira |
| authorships[16].countries | BR |
| authorships[16].affiliations[0].institution_ids | https://openalex.org/I150729083 |
| authorships[16].affiliations[0].raw_affiliation_string | Departamento de Biologia Celular, Universidade de Brasília (UNB), Brasília, Brazil. |
| authorships[16].institutions[0].id | https://openalex.org/I150729083 |
| authorships[16].institutions[0].ror | https://ror.org/02xfp8v59 |
| authorships[16].institutions[0].type | education |
| authorships[16].institutions[0].lineage | https://openalex.org/I150729083 |
| authorships[16].institutions[0].country_code | BR |
| authorships[16].institutions[0].display_name | Universidade de Brasília |
| authorships[16].author_position | middle |
| authorships[16].raw_author_name | Geovani de Oliveria Ribeiro |
| authorships[16].is_corresponding | False |
| authorships[16].raw_affiliation_strings | Departamento de Biologia Celular, Universidade de Brasília (UNB), Brasília, Brazil. |
| authorships[17].author.id | https://openalex.org/A5055608441 |
| authorships[17].author.orcid | https://orcid.org/0000-0002-3502-3929 |
| authorships[17].author.display_name | Steven S. Witkin |
| authorships[17].countries | BR |
| authorships[17].affiliations[0].institution_ids | https://openalex.org/I4210145268 |
| authorships[17].affiliations[0].raw_affiliation_string | Departamento de Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil. |
| authorships[17].institutions[0].id | https://openalex.org/I4210145268 |
| authorships[17].institutions[0].ror | https://ror.org/03se9eg94 |
| authorships[17].institutions[0].type | healthcare |
| authorships[17].institutions[0].lineage | https://openalex.org/I4210145268 |
| authorships[17].institutions[0].country_code | BR |
| authorships[17].institutions[0].display_name | Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo |
| authorships[17].author_position | middle |
| authorships[17].raw_author_name | Steven S Witkin |
| authorships[17].is_corresponding | False |
| authorships[17].raw_affiliation_strings | Departamento de Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil. |
| authorships[18].author.id | https://openalex.org/A5113976416 |
| authorships[18].author.orcid | |
| authorships[18].author.display_name | Gavin Cloherty |
| authorships[18].countries | US |
| authorships[18].affiliations[0].institution_ids | https://openalex.org/I4210142393 |
| authorships[18].affiliations[0].raw_affiliation_string | Infectious Diseases Research, Abbott Diagnostics, Abbott Park, United States of America. |
| authorships[18].institutions[0].id | https://openalex.org/I4210142393 |
| authorships[18].institutions[0].ror | https://ror.org/041w95745 |
| authorships[18].institutions[0].type | nonprofit |
| authorships[18].institutions[0].lineage | https://openalex.org/I4210142393 |
| authorships[18].institutions[0].country_code | US |
| authorships[18].institutions[0].display_name | Abbott Fund |
| authorships[18].author_position | middle |
| authorships[18].raw_author_name | Gavin A Cloherty |
| authorships[18].is_corresponding | False |
| authorships[18].raw_affiliation_strings | Infectious Diseases Research, Abbott Diagnostics, Abbott Park, United States of America. |
| authorships[19].author.id | https://openalex.org/A5023245595 |
| authorships[19].author.orcid | https://orcid.org/0000-0001-5655-8108 |
| authorships[19].author.display_name | Maria Cássia Mendes-Corrêa |
| authorships[19].countries | BR |
| authorships[19].affiliations[0].institution_ids | https://openalex.org/I4210145268 |
| authorships[19].affiliations[0].raw_affiliation_string | Departamento de Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil. |
| authorships[19].institutions[0].id | https://openalex.org/I4210145268 |
| authorships[19].institutions[0].ror | https://ror.org/03se9eg94 |
| authorships[19].institutions[0].type | healthcare |
| authorships[19].institutions[0].lineage | https://openalex.org/I4210145268 |
| authorships[19].institutions[0].country_code | BR |
| authorships[19].institutions[0].display_name | Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo |
| authorships[19].author_position | last |
| authorships[19].raw_author_name | Maria Cassia Mendes-Correa |
| authorships[19].is_corresponding | False |
| authorships[19].raw_affiliation_strings | Departamento de Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil. |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | http://insight.jci.org/articles/view/189295/files/pdf |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-05-21T00:00:00 |
| display_name | Metagenomic detection of central nervous system infections missedby conventional testing |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T13201 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 0.9660999774932861 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2725 |
| primary_topic.subfield.display_name | Infectious Diseases |
| primary_topic.display_name | Infectious Encephalopathies and Encephalitis |
| related_works | https://openalex.org/W2210738511, https://openalex.org/W2487541429, https://openalex.org/W1910109602, https://openalex.org/W2080583581, https://openalex.org/W4297131566, https://openalex.org/W2017364432, https://openalex.org/W2329606903, https://openalex.org/W3195915274, https://openalex.org/W4285082713, https://openalex.org/W2344981695 |
| cited_by_count | 1 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 1 |
| locations_count | 3 |
| best_oa_location.id | doi:10.1172/jci.insight.189295 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S2764964142 |
| best_oa_location.source.issn | 2379-3708 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 2379-3708 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | JCI Insight |
| best_oa_location.source.host_organization | https://openalex.org/P4310320279 |
| best_oa_location.source.host_organization_name | American Society for Clinical Investigation |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310320279 |
| best_oa_location.source.host_organization_lineage_names | American Society for Clinical Investigation |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | http://insight.jci.org/articles/view/189295/files/pdf |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | JCI Insight |
| best_oa_location.landing_page_url | https://doi.org/10.1172/jci.insight.189295 |
| primary_location.id | doi:10.1172/jci.insight.189295 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S2764964142 |
| primary_location.source.issn | 2379-3708 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 2379-3708 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | JCI Insight |
| primary_location.source.host_organization | https://openalex.org/P4310320279 |
| primary_location.source.host_organization_name | American Society for Clinical Investigation |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310320279 |
| primary_location.source.host_organization_lineage_names | American Society for Clinical Investigation |
| primary_location.license | cc-by |
| primary_location.pdf_url | http://insight.jci.org/articles/view/189295/files/pdf |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | JCI Insight |
| primary_location.landing_page_url | https://doi.org/10.1172/jci.insight.189295 |
| publication_date | 2025-05-20 |
| publication_year | 2025 |
| referenced_works | https://openalex.org/W2278452577, https://openalex.org/W4386070057, https://openalex.org/W4200596104, https://openalex.org/W4399889251, https://openalex.org/W2953017819, https://openalex.org/W2075923127, https://openalex.org/W4404792220, https://openalex.org/W4407744716, https://openalex.org/W3041806528, https://openalex.org/W4297905796, https://openalex.org/W2338572855, https://openalex.org/W3095005816, https://openalex.org/W4207008934, https://openalex.org/W2893246696, https://openalex.org/W3100421715, https://openalex.org/W3199553074, https://openalex.org/W1982918005, https://openalex.org/W2886762792, https://openalex.org/W4225136253, https://openalex.org/W4387563455, https://openalex.org/W6785103269, https://openalex.org/W2419428775, https://openalex.org/W4391825169, https://openalex.org/W1998690030, https://openalex.org/W2065415755, https://openalex.org/W4380730395, https://openalex.org/W2114290006, https://openalex.org/W2912320471, https://openalex.org/W4390972398, https://openalex.org/W2591371833, https://openalex.org/W2012199451, https://openalex.org/W2110149887, https://openalex.org/W2971626513, https://openalex.org/W2053912200, https://openalex.org/W2156735755, https://openalex.org/W2067288864, https://openalex.org/W2068644302, https://openalex.org/W2020320734, https://openalex.org/W2160004262, https://openalex.org/W2916897015, https://openalex.org/W2122349387, https://openalex.org/W2120455580, https://openalex.org/W2739183564, https://openalex.org/W2154196920, https://openalex.org/W2137442337, https://openalex.org/W2103441770, https://openalex.org/W2951149542, https://openalex.org/W2964864378, https://openalex.org/W2152239989, https://openalex.org/W3165247538, https://openalex.org/W4289527519, https://openalex.org/W2169112940, https://openalex.org/W2085926377 |
| referenced_works_count | 53 |
| abstract_inverted_index.= | 121, 126 |
| abstract_inverted_index.a | 35, 62, 69, 86 |
| abstract_inverted_index.(n | 120, 125 |
| abstract_inverted_index.65 | 133 |
| abstract_inverted_index.as | 85, 113 |
| abstract_inverted_index.by | 13, 118 |
| abstract_inverted_index.in | 29, 34, 40, 92, 105, 132 |
| abstract_inverted_index.is | 3 |
| abstract_inverted_index.no | 95 |
| abstract_inverted_index.of | 8, 65, 139, 141, 177, 184 |
| abstract_inverted_index.to | 16, 68, 89, 186, 196 |
| abstract_inverted_index.227 | 110 |
| abstract_inverted_index.277 | 140 |
| abstract_inverted_index.292 | 106 |
| abstract_inverted_index.308 | 142 |
| abstract_inverted_index.600 | 50 |
| abstract_inverted_index.CNS | 166, 178 |
| abstract_inverted_index.The | 19 |
| abstract_inverted_index.and | 10, 55, 58, 75, 123, 159, 180, 193 |
| abstract_inverted_index.for | 61, 168 |
| abstract_inverted_index.the | 161, 169, 175, 182 |
| abstract_inverted_index.was | 47, 83, 97 |
| abstract_inverted_index.144) | 122 |
| abstract_inverted_index.2018 | 54 |
| abstract_inverted_index.2019 | 57 |
| abstract_inverted_index.40). | 127 |
| abstract_inverted_index.B19, | 152 |
| abstract_inverted_index.São | 41 |
| abstract_inverted_index.from | 49 |
| abstract_inverted_index.high | 6 |
| abstract_inverted_index.used | 84 |
| abstract_inverted_index.were | 79, 130 |
| abstract_inverted_index.with | 5, 31, 109, 165 |
| abstract_inverted_index.(CNS) | 27 |
| abstract_inverted_index.(CSF) | 46 |
| abstract_inverted_index.March | 53 |
| abstract_inverted_index.These | 172 |
| abstract_inverted_index.acute | 23 |
| abstract_inverted_index.being | 163 |
| abstract_inverted_index.broad | 63 |
| abstract_inverted_index.first | 170 |
| abstract_inverted_index.fluid | 45 |
| abstract_inverted_index.local | 70 |
| abstract_inverted_index.other | 156 |
| abstract_inverted_index.range | 64 |
| abstract_inverted_index.rates | 7 |
| abstract_inverted_index.study | 21, 39 |
| abstract_inverted_index.time. | 171 |
| abstract_inverted_index.viral | 114 |
| abstract_inverted_index.where | 94 |
| abstract_inverted_index.(mNGS) | 138 |
| abstract_inverted_index.Paulo, | 42 |
| abstract_inverted_index.access | 15 |
| abstract_inverted_index.agents | 129 |
| abstract_inverted_index.caused | 117 |
| abstract_inverted_index.future | 198 |
| abstract_inverted_index.inform | 190 |
| abstract_inverted_index.latter | 162 |
| abstract_inverted_index.system | 26 |
| abstract_inverted_index.(77.7%) | 111 |
| abstract_inverted_index.Brazil. | 43 |
| abstract_inverted_index.address | 197 |
| abstract_inverted_index.between | 52 |
| abstract_inverted_index.central | 24 |
| abstract_inverted_index.current | 20 |
| abstract_inverted_index.efforts | 195 |
| abstract_inverted_index.gondii, | 154 |
| abstract_inverted_index.improve | 187 |
| abstract_inverted_index.limited | 14 |
| abstract_inverted_index.methods | 78 |
| abstract_inverted_index.nervous | 25 |
| abstract_inverted_index.several | 146 |
| abstract_inverted_index.species | 158 |
| abstract_inverted_index.support | 194 |
| abstract_inverted_index.testing | 101 |
| abstract_inverted_index.(22.3%). | 135 |
| abstract_inverted_index.(48.6%), | 108 |
| abstract_inverted_index.Nonviral | 128 |
| abstract_inverted_index.November | 56 |
| abstract_inverted_index.Standard | 73, 100 |
| abstract_inverted_index.applied. | 80 |
| abstract_inverted_index.approach | 88 |
| abstract_inverted_index.assessed | 22 |
| abstract_inverted_index.enrolled | 33 |
| abstract_inverted_index.etiology | 91 |
| abstract_inverted_index.findings | 173 |
| abstract_inverted_index.pathogen | 96 |
| abstract_inverted_index.patients | 30, 51, 107, 134, 144 |
| abstract_inverted_index.revealed | 145 |
| abstract_inverted_index.screened | 60 |
| abstract_inverted_index.according | 67 |
| abstract_inverted_index.accuracy, | 189 |
| abstract_inverted_index.collected | 48 |
| abstract_inverted_index.confirmed | 112 |
| abstract_inverted_index.highlight | 181 |
| abstract_inverted_index.including | 150 |
| abstract_inverted_index.infection | 167 |
| abstract_inverted_index.initially | 59, 98 |
| abstract_inverted_index.instances | 93 |
| abstract_inverted_index.molecular | 76 |
| abstract_inverted_index.mortality | 9 |
| abstract_inverted_index.pathogens | 66 |
| abstract_inverted_index.potential | 148, 183 |
| abstract_inverted_index.treatment | 191 |
| abstract_inverted_index.Parvovirus | 151 |
| abstract_inverted_index.Toxoplasma | 153 |
| abstract_inverted_index.Vesivirus, | 160 |
| abstract_inverted_index.additional | 147 |
| abstract_inverted_index.algorithm. | 72 |
| abstract_inverted_index.associated | 4, 164 |
| abstract_inverted_index.complexity | 176 |
| abstract_inverted_index.compounded | 12 |
| abstract_inverted_index.diagnostic | 17, 37, 71, 77, 188 |
| abstract_inverted_index.etiologies | 104 |
| abstract_inverted_index.identified | 102, 131 |
| abstract_inverted_index.infections | 28, 179 |
| abstract_inverted_index.infectious | 1, 103 |
| abstract_inverted_index.morbidity, | 11 |
| abstract_inverted_index.pandemics. | 199 |
| abstract_inverted_index.resources. | 18 |
| abstract_inverted_index.sequencing | 82, 137 |
| abstract_inverted_index.underscore | 174 |
| abstract_inverted_index.Metagenomic | 81, 136 |
| abstract_inverted_index.enterovirus | 157 |
| abstract_inverted_index.etiologies, | 149 |
| abstract_inverted_index.identified. | 99 |
| abstract_inverted_index.infections, | 115 |
| abstract_inverted_index.strategies, | 192 |
| abstract_inverted_index.undiagnosed | 143 |
| abstract_inverted_index.metagenomics | 185 |
| abstract_inverted_index.surveillance | 38 |
| abstract_inverted_index.Cerebrospinal | 44 |
| abstract_inverted_index.complementary | 87 |
| abstract_inverted_index.enteroviruses | 119 |
| abstract_inverted_index.herpesviruses | 124 |
| abstract_inverted_index.investigating | 90 |
| abstract_inverted_index.predominantly | 116 |
| abstract_inverted_index.hospital-based | 36 |
| abstract_inverted_index.Picobirnavirus, | 155 |
| abstract_inverted_index.microbiological | 74 |
| abstract_inverted_index.Community-acquired | 0 |
| abstract_inverted_index.meningoencephalitis | 2, 32 |
| cited_by_percentile_year.max | 95 |
| cited_by_percentile_year.min | 91 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 20 |
| citation_normalized_percentile.value | 0.86368255 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |