Metal‐Based Nanoparticles: Shedding Light on Metal‐Based Nanoparticles in Zebrafish by Computed Tomography with Micrometer Resolution (Small 31/2020) Article Swipe

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Nanoparticle Materials science Micrometer Synchrotron radiation Zebrafish Computed tomography Soft tissue Biomedical engineering Nanotechnology Chemistry Radiology Optics Medicine Physics Biochemistry Gene

Emre Çörek , Griffin Rodgers , Stefan Siegrist , Tomaž Einfalt , Pascal Detampel , Christian M. Schlepütz , Sandro Sieber , Pascal Fluder , G. V. Schulz , Harald Unterweger , Christoph Alexiou , Bert Müller , Maxim Puchkov , Jörg Huwyler ·

YOU? · · 2020 · Open Access · · DOI: https://doi.org/10.1002/smll.202070170 · OA: W3047666316

Superparamagnetic iron oxide nanoparticles (SPIONs) are clinically used as diagnostic agents, serving as a contrast media when exposed to a magnetic field. In article number 2000746, Jörg Huwyler and co-workers evaluate synchrotron radiation-based hard X-ray tomography (SRμCT) for the localization of SPIONs in soft tissues. In the cover, the tissue distribution of SPIONs is visualized after intravenous injection in a three-day old zebrafish embryo by SRμCT, with views within the blood vessel looking at the surrounding soft tissue and onto SPIONs engulfed by macrophages. Image: Courtesy of Jan Stephan Bolten.