Metformin alleviates reactive gliosis and neurodegeneration, improving cognitive deficit in a rat model of temporal lobe epilepsy Article Swipe
Sree Lalitha Bojja
,
Shashi Anand
,
Ranjana W. Minz
,
Bikash Medhi
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1016/j.brainres.2024.149138
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1016/j.brainres.2024.149138
Cognitive impairment is a prevalent co-morbidity associated with epilepsy. Emerging studies indicate that neuroinflammation could be a possible link between epilepsy and its comorbidities, including cognitive impairment. In this context, the roles of glial activation, proinflammatory mediators, and neuronal death have been well studied and correlated with epilepsy-associated cognitive impairment in animal studies. While recent reports have demonstrated the anti-epileptogenic and anti-convulsant actions of metformin, its effect on epilepsy associated cognitive deficit remains unknown. Therefore, the current study investigated the effect of metformin treatment on neuroinflammation, neurodegeneration, and cognitive deficits after inducing status epilepticus (SE) with lithium-pilocarpine in rats. Metformin treatment improved the hippocampal-dependent spatial and recognition memory in Morris water maze and Novel object recognition tasks, respectively. Further, metformin treatment attenuated microglial and astroglial activation, accompanied by reduced IL-1β, COX-2 and NF-ĸβ gene expression. Additionally, metformin conferred neuroprotection by inhibiting the neuronal death as assessed by Nissl staining and transmission electron microscopy. These findings suggest that metformin holds promise as a therapeutic intervention for cognitive impairment associated with epilepsy, possibly through its modulation of glial activation and neuronal survival. Further research is needed to elucidate the precise mechanisms and to assess the long-term effect of metformin in epilepsy-associated cognitive impairment.
Related Topics
Concepts
Epilepsy
Neuroinflammation
Neuroscience
Neuroprotection
Cognitive deficit
Morris water navigation task
Metformin
Medicine
Status epilepticus
Epileptogenesis
Neurodegeneration
Hippocampus
Gliosis
Psychology
Cognition
Internal medicine
Endocrinology
Inflammation
Diabetes mellitus
Cognitive impairment
Disease
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.brainres.2024.149138
- OA Status
- hybrid
- Cited By
- 8
- References
- 42
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4401480115
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4401480115Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1016/j.brainres.2024.149138Digital Object Identifier
- Title
-
Metformin alleviates reactive gliosis and neurodegeneration, improving cognitive deficit in a rat model of temporal lobe epilepsyWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
-
2024-08-10Full publication date if available
- Authors
-
Sree Lalitha Bojja, Shashi Anand, Ranjana W. Minz, Bikash MedhiList of authors in order
- Landing page
-
https://doi.org/10.1016/j.brainres.2024.149138Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
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https://doi.org/10.1016/j.brainres.2024.149138Direct OA link when available
- Concepts
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Epilepsy, Neuroinflammation, Neuroscience, Neuroprotection, Cognitive deficit, Morris water navigation task, Metformin, Medicine, Status epilepticus, Epileptogenesis, Neurodegeneration, Hippocampus, Gliosis, Psychology, Cognition, Internal medicine, Endocrinology, Inflammation, Diabetes mellitus, Cognitive impairment, DiseaseTop concepts (fields/topics) attached by OpenAlex
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8Total citation count in OpenAlex
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2025: 6, 2024: 2Per-year citation counts (last 5 years)
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42Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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