Metformin: From Diabetes to Cancer—Unveiling Molecular Mechanisms and Therapeutic Strategies Article Swipe
Emilia Amengual-Cladera
,
Pere Miquel Morla-Barcelo
,
Andrea Morán-Costoya
,
Adamo Valle
,
Daniel Gabriel Pons
,
Jorge Sastre‐Serra
,
Pilar Roca
,
Mercedes Nadal‐Serrano
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.20944/preprints202403.1343.v1
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.20944/preprints202403.1343.v1
Metformin, a widely used anti-diabetic drug, has garnered attention for its potential in cancer management, particularly in breast and colorectal cancer. It is established that metformin reduces mitochondrial respiration, but its specific molecular targets within mitochondria vary. Proposed mechanisms include inhibiting mitochondrial respiratory chain Complex I and/or Complex IV, and mitochondrial glycerophosphate dehydrogenase, among others. These actions lead to cellular energy deficits, redox state changes, and several molecular changes that reduce hyperglycemia in type 2 diabetic patients. Clinical evidence supports metformin’s role in cancer prevention in type 2 diabetes mellitus patients. Moreover, in these patients with breast and colorectal cancer, metformin consumption leads to an improvement of survival outcomes and prognosis. The synergistic effects of metformin with chemotherapy and immunotherapy highlights its potential as an adjunctive therapy for breast and colorectal cancer. However, nuanced findings underscore the need for further research and stratification by molecular subtype, particularly for breast cancer. This comprehensive review integrates metformin-related findings from epidemiological, clinical, and preclinical studies in breast and colorectal cancer. Here, we discuss current research addressed to define metformin's bioavailability and efficacy, exploring novel metformin-based compounds and drug delivery systems, including derivatives targeting mitochondria, combination therapies, and novel nanoformulations, showing enhanced anticancer effects.
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.20944/preprints202403.1343.v1
- https://www.preprints.org/manuscript/202403.1343/v1/download
- OA Status
- green
- Cited By
- 10
- References
- 171
- Related Works
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- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
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- DOI
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https://doi.org/10.20944/preprints202403.1343.v1Digital Object Identifier
- Title
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Metformin: From Diabetes to Cancer—Unveiling Molecular Mechanisms and Therapeutic StrategiesWork title
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-03-22Full publication date if available
- Authors
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Emilia Amengual-Cladera, Pere Miquel Morla-Barcelo, Andrea Morán-Costoya, Adamo Valle, Daniel Gabriel Pons, Jorge Sastre‐Serra, Pilar Roca, Mercedes Nadal‐SerranoList of authors in order
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https://doi.org/10.20944/preprints202403.1343.v1Publisher landing page
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https://www.preprints.org/manuscript/202403.1343/v1/downloadDirect link to full text PDF
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YesWhether a free full text is available
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greenOpen access status per OpenAlex
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https://www.preprints.org/manuscript/202403.1343/v1/downloadDirect OA link when available
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Metformin, Diabetes mellitus, Medicine, Cancer, Internal medicine, EndocrinologyTop concepts (fields/topics) attached by OpenAlex
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10Total citation count in OpenAlex
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2025: 4, 2024: 6Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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