Methanolic Extract of Mallotus roxburghianus Muell. Exhibit Anti-Cancer Activity against Dalton’s Lymphoma Ascites (DLA) bearing Mice via Alterations of Apoptotic Genes E xpression and Redox-Homeostasis Article Swipe
Mary Zosangzuali
,
Fanai Lalsangpuii
,
C. Lalmuansangi
,
Lalchhandami Tochhawng
,
Amit Kumar Trivedi
,
Nachimuthu Senthil Kumar
,
Zothansiama Zothansiama
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.17485/ijst/v16sp1.msc11
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.17485/ijst/v16sp1.msc11
Objectives: The current study examined the anti-cancer effects of methanolic extract of Mallotus roxburghianus (MRME) using Dalton’s Lymphoma Ascites (DLA) bearing mice. Methods: According to OECD guidelines, the acute toxicity of MRME was assessed, and the LD50 of MRME was estimated using probit analysis. The effects of MRME on survival time, weight change, and antioxidant/oxidant status were determined in DLA mice by administering the animals with different doses of MRME, and doxorubicin was used as a standard reference drug. Cytotoxicity, activities of serum enzymes, and haematological parameters were also determined after treatment with MRME. Effects of MRME on DNA damage and the differential gene expression of apoptotic genes were also studied using Comet assay and qPCR techniques respectively. Findings: MRME significantly reduced tumour growth and extended the survival duration of tumour-bearing mice with increased in MST (26.0 0.72), AST (23.0 0.60), % IMLS (79.3 0.58) and % IALS (50.0 0.91) after treatment with 150 mg/kg. MRME also decreased antioxidant activities and enhanced lipid peroxidation. Decreased RBC levels and haemoglobin content in DLA mice were significantly reversed by MRME treatment. MRME also reduces AST, ALT, LDH, and CRE levels, which were otherwise increased in the DLA control animals. The apoptosis-based anti-cancer effects of M. roxburghianus were revealed by the induction of DNA damage, up-regulation of pro-apoptotic genes, and down-regulation of anti-apoptotic genes in DLA mice after M. roxburghianus treatment. MRME treatment increased the relative expressions of pro-apoptotic genes such as Apaf1, p53 and Bax by 3.19, 3.81 and6.06 folds, respectively when compared to untreated control. Novelty: Our study demonstrates the anti-cancer activities of the methanolic extract of M. roxburghianus leaves thus potentiating the use of the plant for further development of anti-cancer agents. Keywords: Mallotus roxburghianus; Dalton’s Lymphoma Ascites; Anticancer; DNA damage; Apoptotic genes
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.17485/ijst/v16sp1.msc11
- https://sciresol.s3.us-east-2.amazonaws.com/IJST/Articles/2023/SP-1/msc-11.pdf
- OA Status
- diamond
- References
- 20
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4387309124
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4387309124Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.17485/ijst/v16sp1.msc11Digital Object Identifier
- Title
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Methanolic Extract of Mallotus roxburghianus Muell. Exhibit Anti-Cancer Activity against Dalton’s Lymphoma Ascites (DLA) bearing Mice via Alterations of Apoptotic Genes E xpression and Redox-HomeostasisWork title
- Type
-
articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-10-03Full publication date if available
- Authors
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Mary Zosangzuali, Fanai Lalsangpuii, C. Lalmuansangi, Lalchhandami Tochhawng, Amit Kumar Trivedi, Nachimuthu Senthil Kumar, Zothansiama ZothansiamaList of authors in order
- Landing page
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https://doi.org/10.17485/ijst/v16sp1.msc11Publisher landing page
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https://sciresol.s3.us-east-2.amazonaws.com/IJST/Articles/2023/SP-1/msc-11.pdfDirect link to full text PDF
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YesWhether a free full text is available
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diamondOpen access status per OpenAlex
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https://sciresol.s3.us-east-2.amazonaws.com/IJST/Articles/2023/SP-1/msc-11.pdfDirect OA link when available
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Apoptosis, DNA damage, Comet assay, Pharmacology, Biology, Cytotoxicity, Molecular biology, Lipid peroxidation, Antioxidant, Immunology, Chemistry, Biochemistry, DNA, In vitroTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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