Indian Journal of Science and Technology • Vol 16 • No sp1
Methanolic Extract of Mallotus roxburghianus Muell. Exhibit Anti-Cancer Activity against Dalton’s Lymphoma Ascites (DLA) bearing Mice via Alterations of Apoptotic Genes E xpression and Redox-Homeostasis
October 2023 • Mary Zosangzuali, Fanai Lalsangpuii, C. Lalmuansangi, Lalchhandami Tochhawng, Amit Kumar Trivedi, Nachimuthu Senthil Kumar, Zothansiama Zothansiama
Objectives: The current study examined the anti-cancer effects of methanolic extract of Mallotus roxburghianus (MRME) using Dalton’s Lymphoma Ascites (DLA) bearing mice. Methods: According to OECD guidelines, the acute toxicity of MRME was assessed, and the LD50 of MRME was estimated using probit analysis. The effects of MRME on survival time, weight change, and antioxidant/oxidant status were determined in DLA mice by administering the animals with different doses of MRME, and doxorubicin was used as a standard r…