Methylparaben Modulates the Relationship Between Autophagy and Apoptosis in Head and Neck Squamous Cell Carcinoma Lines Article Swipe
Ewa Jablonska
,
Agnieszka Iwaniuk
,
Wioletta Ratajczak-Wrona
,
Kinga Henryka Nowacka
,
Marzena Garley
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.2478/aite-2026-0005
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.2478/aite-2026-0005
In light of the increasing incidence of head and neck cancer and the widespread occurrence of methylparabens (MeP) in the human environment, which mimic the action of endogenous estrogens, we investigated the effect of this compound on head and neck squamous cell carcinoma (HNSCC) cells. We took into account autophagy and apoptosis, as well as the ability of HNSCC cell lines FaDu and Detroit 562 to proliferate, and the effect of flavonoids on the determined parameters. The obtained results revealed that MeP inhibits autophagy, indicated by downregulation of autophagy-related proteins such as beclin-1, LC3β, and APG5 expression in both cancer cell lines. Moreover, MeP, by changing the expression of mitochondrial proteins Bcl-2 and Bax, may be responsible for the reduction of apoptosis and the increased proliferation of cancer cells associated with high expression of caspase-3. The applied flavonoids restored the values of the tested parameters to the level observed in cells not exposed to MeP. In conclusion, our studies have shown for the first time that MeP, in addition to well-documented exposure factors, may facilitate the development of HNSCCs. We suggest that the adverse effects of MeP can be reduced by the use of flavonoids, which may lead to the inhibition of HNSCC cells growth.
Related Topics
Concepts
Autophagy
Apoptosis
Head and neck squamous-cell carcinoma
Downregulation and upregulation
Cell culture
Cancer research
Chemistry
Cell
Cancer
Cancer cell
Cell growth
Endogeny
Head and neck cancer
Programmed cell death
Basal cell
Squamous carcinoma
Epidermoid carcinoma
Carcinogenesis
Head and neck
Cell biology
Intracellular
Growth inhibition
Biology
Carcinoma
Mitochondrion
Methylparaben
Mode of action
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.2478/aite-2026-0005
- OA Status
- hybrid
- References
- 41
- OpenAlex ID
- https://openalex.org/W7106494617
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W7106494617Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.2478/aite-2026-0005Digital Object Identifier
- Title
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Methylparaben Modulates the Relationship Between Autophagy and Apoptosis in Head and Neck Squamous Cell Carcinoma LinesWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-11-24Full publication date if available
- Authors
-
Ewa Jablonska, Agnieszka Iwaniuk, Wioletta Ratajczak-Wrona, Kinga Henryka Nowacka, Marzena GarleyList of authors in order
- Landing page
-
https://doi.org/10.2478/aite-2026-0005Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.2478/aite-2026-0005Direct OA link when available
- Concepts
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Autophagy, Apoptosis, Head and neck squamous-cell carcinoma, Downregulation and upregulation, Cell culture, Cancer research, Chemistry, Cell, Cancer, Cancer cell, Cell growth, Endogeny, Head and neck cancer, Programmed cell death, Basal cell, Squamous carcinoma, Epidermoid carcinoma, Carcinogenesis, Head and neck, Cell biology, Intracellular, Growth inhibition, Biology, Carcinoma, Mitochondrion, Methylparaben, Mode of actionTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
- References (count)
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41Number of works referenced by this work
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