Micellar Nanocarriers from Dendritic Macromolecules Containing Fluorescent Coumarin Moieties Article Swipe
Alberto Concellón
,
María San Anselmo
,
Silvia Hernández‐Ainsa
,
Pilar Romero
,
Mercedes Marcos
,
José Luís Serrano
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.3390/polym12122872
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.3390/polym12122872
The design of efficient drug-delivery vehicles remains a big challenge in materials science. Herein, we describe a novel class of amphiphilic hybrid dendrimers that consist of a poly(amidoamine) (PAMAM) dendritic core functionalized with bisMPA dendrons bearing cholesterol and coumarin moieties. Their self-assembly behavior both in bulk and in water was investigated. All dendrimers exhibited smectic A or hexagonal columnar liquid crystal organizations, depending on the generation of the dendrimer. In water, these dendrimers self-assembled to form stable spherical micelles that could encapsulate Nile Red, a hydrophobic model compound. The cell viability in vitro of the micelles was studied in HeLa cell line, and proved to be non-toxic up to 72 h of incubation. Therefore, these spherical micelles allow the encapsulation of hydrophobic molecules, and at the same time provided fluorescent traceability due to the presence of coumarin units in their chemical structure, demonstrating the potential of these dendrimers as nanocarriers for drug-delivery applications.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/polym12122872
- https://www.mdpi.com/2073-4360/12/12/2872/pdf
- OA Status
- gold
- Cited By
- 18
- References
- 31
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3108218323
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3108218323Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/polym12122872Digital Object Identifier
- Title
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Micellar Nanocarriers from Dendritic Macromolecules Containing Fluorescent Coumarin MoietiesWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2020Year of publication
- Publication date
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2020-11-30Full publication date if available
- Authors
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Alberto Concellón, María San Anselmo, Silvia Hernández‐Ainsa, Pilar Romero, Mercedes Marcos, José Luís SerranoList of authors in order
- Landing page
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https://doi.org/10.3390/polym12122872Publisher landing page
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https://www.mdpi.com/2073-4360/12/12/2872/pdfDirect link to full text PDF
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
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https://www.mdpi.com/2073-4360/12/12/2872/pdfDirect OA link when available
- Concepts
-
Dendrimer, Nanocarriers, Nile red, Micelle, Amphiphile, Fluorescence, Macromolecule, Drug delivery, Materials science, Chemistry, Nanotechnology, Organic chemistry, Copolymer, Combinatorial chemistry, Polymer chemistry, Polymer, Aqueous solution, Quantum mechanics, Biochemistry, PhysicsTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
18Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1, 2024: 1, 2023: 5, 2022: 7, 2021: 4Per-year citation counts (last 5 years)
- References (count)
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31Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| sustainable_development_goals[0].display_name | Clean water and sanitation |
| citation_normalized_percentile.value | 0.80955458 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |