Micro-circulating hyperdynamic blood flow as a key pathogenic factor in early sepsis Article Swipe
Xinghuai Feng
,
Wei Liu
,
Yunbo Sun
,
Ye Zeng
,
Buwei Yu
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-3442290/v1
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-3442290/v1
Objective: The pathogenesis of sepsis is still unknown. Sepsis 3.0 points out that "how to define sepsis and septic shock itself is still a challenge". This study confirmed the inevitability and universality of Hyperdynamic microcirculation in sepsis, and put forward the detoxification mechanism of Hyperdynamic blood flow and the "Feng- Bernoulli warm shock" mechanism, that is, the pathogenic mechanism of sepsis. Methods : Sepsis models of pigs, rabbits and sheep were established by intravenous injection of lipopolysaccharide (LPS) and cecal ligation and perforation (CLP), and the changes of sublingual microcirculation velocity in the same branch before and after modeling were detected. SD rat model of mild sepsis was established to verify that the acceleration of blood flow is the manifestation of immune detoxification mechanism. Results : The blood flow in the same branch was accelerated after the animal sepsis model was established, which was more than doubled on average. The microcirculation blood flow accelerated before the change of cardiac output CO. Rats entered a toxic state after the rapid blood flow occurred, but they could heal themselves. Conclusion : The acceleration of microcirculation blood flow in sepsis is inevitable and universal, which is the cause of high output and low resistance of sepsis, and has the functions of accelerating detoxification and immunity. However, due to Bernoulli effect, it will cause oxygen exchange disorder, which is named "Feng- Bernoulli warm shock", which is the primary pathogenic mechanism of early sepsis.
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.21203/rs.3.rs-3442290/v1
- https://www.researchsquare.com/article/rs-3442290/latest.pdf
- OA Status
- green
- References
- 3
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4387666073
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4387666073Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.21203/rs.3.rs-3442290/v1Digital Object Identifier
- Title
-
Micro-circulating hyperdynamic blood flow as a key pathogenic factor in early sepsisWork title
- Type
-
preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-10-16Full publication date if available
- Authors
-
Xinghuai Feng, Wei Liu, Yunbo Sun, Ye Zeng, Buwei YuList of authors in order
- Landing page
-
https://doi.org/10.21203/rs.3.rs-3442290/v1Publisher landing page
- PDF URL
-
https://www.researchsquare.com/article/rs-3442290/latest.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.researchsquare.com/article/rs-3442290/latest.pdfDirect OA link when available
- Concepts
-
Sepsis, Microcirculation, Medicine, Shock (circulatory), Blood flow, Septic shock, Pathogenesis, Immunology, Internal medicineTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
0Total citation count in OpenAlex
- References (count)
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3Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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