Microarray integrated spatial transcriptomics (MIST) for affordable and robust digital pathology Article Swipe
Juwayria
,
Priyansh Shrivastava
,
Kaustar Yadav
,
Sourabh Das
,
Shubham Mittal
,
Sunil Kumar
,
Deepali Jain
,
Prabhat Singh Malik
,
Ishaan Gupta
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1038/s41540-024-00462-1
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1038/s41540-024-00462-1
10X Visium, a popular Spatial transcriptomics (ST) method, faces limited adoption due to its high cost and restricted sample usage per slide. To address these issues, we propose Microarray Integrated Spatial Transcriptomics (MIST), combining conventional tissue microarray (TMA) with Visium, using laser-cutting and 3D printing to enhance slide throughput. Our design facilitates independent replication and customization in individual labs to suit specific experimental needs. We provide a step-by-step guide from designing TMAs to the library preparation step. We demonstrate MIST’s cost-effectiveness and technical benefits over Visium and GeoMx Nanostring. We also introduce ‘AnnotateMap’, a novel computational tool for efficient analysis of multiple ROIs processed through MIST.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1038/s41540-024-00462-1
- OA Status
- gold
- Cited By
- 5
- References
- 13
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4404877901
All OpenAlex metadata
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https://openalex.org/W4404877901Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1038/s41540-024-00462-1Digital Object Identifier
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Microarray integrated spatial transcriptomics (MIST) for affordable and robust digital pathologyWork title
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articleOpenAlex work type
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enPrimary language
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2024Year of publication
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2024-11-30Full publication date if available
- Authors
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Juwayria, Priyansh Shrivastava, Kaustar Yadav, Sourabh Das, Shubham Mittal, Sunil Kumar, Deepali Jain, Prabhat Singh Malik, Ishaan GuptaList of authors in order
- Landing page
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https://doi.org/10.1038/s41540-024-00462-1Publisher landing page
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://doi.org/10.1038/s41540-024-00462-1Direct OA link when available
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Mist, Computer science, Personalization, Microarray, Sample (material), Replication (statistics), Data mining, Biology, World Wide Web, Geography, Gene, Chromatography, Chemistry, Virology, Meteorology, Biochemistry, Gene expressionTop concepts (fields/topics) attached by OpenAlex
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5Total citation count in OpenAlex
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2025: 5Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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