Microbe-Derived Antioxidants Protect IPEC-1 Cells from H2O2-Induced Oxidative Stress, Inflammation and Tight Junction Protein Disruption via Activating the Nrf2 Pathway to Inhibit the ROS/NLRP3/IL-1β Signaling Pathway Article Swipe
Cheng Shen
,
Zhen Luo
,
Sheng Ma
,
Chengbing Yu
,
Ting Lai
,
Shangshang Tang
,
Hongcai Zhang
,
Jing Zhang
,
Weina Xu
,
Jianxiong Xu
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/antiox13050533
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/antiox13050533
Oxidative stress can induce inflammation and tight junction disruption in enterocytes. The initiation of inflammation is thought to commence with the activation of the ROS/NLRP3/IL-1β signaling pathway, marking a crucial starting point in the process. In our previous studies, we found that microbe-derived antioxidants (MAs) showed significant potential in enhancing both antioxidant capabilities and anti-inflammatory effects. The main aim of this research was to investigate the ability of MAs to protect cells from oxidative stress caused by H2O2, to reduce inflammatory responses, and to maintain the integrity of tight junction proteins by modulating the ROS/NLRP3/IL-1β signaling pathway. IPEC-1 cells (1 × 104 cells/well) were initially exposed to 100 mg/L of MAs for 12 h, after which they were subjected to 1 mM H2O2 treatment for 1 h. We utilized small interfering RNA (siRNA) to inhibit the expression of NLRP3 and Nrf2. Inflammatory factors such as IL-1β and antioxidant enzyme activity levels were detected by ELISA. Oxidative stress marker ROS was examined by fluorescence analysis. The NLRP3/IL-1β signaling pathway, Nrf2/HO-1 signaling pathway and tight junction proteins (ZO-1 and Occludin) were detected by RT-qPCR or Western blotting. In our research, it was observed that MA treatment effectively suppressed the notable increase in H2O2-induced inflammatory markers (TNF-α, IL-1β, and IL-18), decreased ROS accumulation, mitigated the expression of NLRP3, ASC, and caspase-1, and promoted the expression of ZO-1 and Occludin. After silencing the NLRP3 gene with siRNA, the protective influence of MAs was observed to be linked with the NLRP3 inflammasome. Additional investigations demonstrated that the treatment with MAs triggered the activation of Nrf2, facilitating its translocation into the nucleus. This process resulted in a notable upregulation of Nrf2, NQO1, and HO-1 expression, along with the initiation of the Nrf2-HO-1 signaling pathway. Consequently, there was an enhancement in the activities of antioxidant enzymes like SOD, GSH-Px, and CAT, which effectively mitigated the accumulation of ROS, thereby ameliorating the oxidative stress state. The antioxidant effectiveness of MAs was additionally heightened in the presence of SFN, an activator of Nrf2. The antioxidant and anti-inflammatory functions of MAs and their role in regulating intestinal epithelial tight junction protein disruption were significantly affected after siRNA knockdown of the Nrf2 gene. These findings suggest that MAs have the potential to reduce H2O2-triggered oxidative stress, inflammation, and disruption of intestinal epithelial tight junction proteins in IPEC-1 cells. This reduction is achieved by blocking the ROS/NLRP3/IL-1β signaling pathway through the activation of the Nrf2 pathway.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/antiox13050533
- https://www.mdpi.com/2076-3921/13/5/533/pdf?version=1714184813
- OA Status
- gold
- Cited By
- 9
- References
- 31
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4396548002
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4396548002Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/antiox13050533Digital Object Identifier
- Title
-
Microbe-Derived Antioxidants Protect IPEC-1 Cells from H2O2-Induced Oxidative Stress, Inflammation and Tight Junction Protein Disruption via Activating the Nrf2 Pathway to Inhibit the ROS/NLRP3/IL-1β Signaling PathwayWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-04-27Full publication date if available
- Authors
-
Cheng Shen, Zhen Luo, Sheng Ma, Chengbing Yu, Ting Lai, Shangshang Tang, Hongcai Zhang, Jing Zhang, Weina Xu, Jianxiong XuList of authors in order
- Landing page
-
https://doi.org/10.3390/antiox13050533Publisher landing page
- PDF URL
-
https://www.mdpi.com/2076-3921/13/5/533/pdf?version=1714184813Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/2076-3921/13/5/533/pdf?version=1714184813Direct OA link when available
- Concepts
-
Occludin, Oxidative stress, Cell biology, Inflammation, Signal transduction, Small interfering RNA, Gene silencing, Chemistry, Tight junction, Antioxidant, Biology, Biochemistry, Immunology, Transfection, GeneTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
9Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 7, 2024: 2Per-year citation counts (last 5 years)
- References (count)
-
31Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4396548002 |
|---|---|
| doi | https://doi.org/10.3390/antiox13050533 |
| ids.doi | https://doi.org/10.3390/antiox13050533 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/38790638 |
| ids.openalex | https://openalex.org/W4396548002 |
| fwci | 11.23771605 |
| type | article |
| title | Microbe-Derived Antioxidants Protect IPEC-1 Cells from H2O2-Induced Oxidative Stress, Inflammation and Tight Junction Protein Disruption via Activating the Nrf2 Pathway to Inhibit the ROS/NLRP3/IL-1β Signaling Pathway |
| biblio.issue | 5 |
| biblio.volume | 13 |
| biblio.last_page | 533 |
| biblio.first_page | 533 |
| topics[0].id | https://openalex.org/T12020 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 0.9789000153541565 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2746 |
| topics[0].subfield.display_name | Surgery |
| topics[0].display_name | Enhanced Recovery After Surgery |
| topics[1].id | https://openalex.org/T10337 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.977400004863739 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2721 |
| topics[1].subfield.display_name | Hepatology |
| topics[1].display_name | Liver Disease and Transplantation |
| topics[2].id | https://openalex.org/T10066 |
| topics[2].field.id | https://openalex.org/fields/13 |
| topics[2].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[2].score | 0.9623000025749207 |
| topics[2].domain.id | https://openalex.org/domains/1 |
| topics[2].domain.display_name | Life Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/1312 |
| topics[2].subfield.display_name | Molecular Biology |
| topics[2].display_name | Gut microbiota and health |
| is_xpac | False |
| apc_list.value | 2200 |
| apc_list.currency | CHF |
| apc_list.value_usd | 2382 |
| apc_paid.value | 2200 |
| apc_paid.currency | CHF |
| apc_paid.value_usd | 2382 |
| concepts[0].id | https://openalex.org/C2775962179 |
| concepts[0].level | 3 |
| concepts[0].score | 0.904029130935669 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q2013337 |
| concepts[0].display_name | Occludin |
| concepts[1].id | https://openalex.org/C2776151105 |
| concepts[1].level | 2 |
| concepts[1].score | 0.8270921111106873 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q898814 |
| concepts[1].display_name | Oxidative stress |
| concepts[2].id | https://openalex.org/C95444343 |
| concepts[2].level | 1 |
| concepts[2].score | 0.7486316561698914 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q7141 |
| concepts[2].display_name | Cell biology |
| concepts[3].id | https://openalex.org/C2776914184 |
| concepts[3].level | 2 |
| concepts[3].score | 0.6735954284667969 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q101991 |
| concepts[3].display_name | Inflammation |
| concepts[4].id | https://openalex.org/C62478195 |
| concepts[4].level | 2 |
| concepts[4].score | 0.6534854769706726 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q828130 |
| concepts[4].display_name | Signal transduction |
| concepts[5].id | https://openalex.org/C22615655 |
| concepts[5].level | 4 |
| concepts[5].score | 0.6441879272460938 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q203221 |
| concepts[5].display_name | Small interfering RNA |
| concepts[6].id | https://openalex.org/C119056186 |
| concepts[6].level | 3 |
| concepts[6].score | 0.6292216181755066 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q1431332 |
| concepts[6].display_name | Gene silencing |
| concepts[7].id | https://openalex.org/C185592680 |
| concepts[7].level | 0 |
| concepts[7].score | 0.5178033113479614 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q2329 |
| concepts[7].display_name | Chemistry |
| concepts[8].id | https://openalex.org/C177779419 |
| concepts[8].level | 2 |
| concepts[8].score | 0.46711692214012146 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q1053832 |
| concepts[8].display_name | Tight junction |
| concepts[9].id | https://openalex.org/C2778004101 |
| concepts[9].level | 2 |
| concepts[9].score | 0.41543465852737427 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q133948 |
| concepts[9].display_name | Antioxidant |
| concepts[10].id | https://openalex.org/C86803240 |
| concepts[10].level | 0 |
| concepts[10].score | 0.2822284698486328 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[10].display_name | Biology |
| concepts[11].id | https://openalex.org/C55493867 |
| concepts[11].level | 1 |
| concepts[11].score | 0.21687942743301392 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q7094 |
| concepts[11].display_name | Biochemistry |
| concepts[12].id | https://openalex.org/C203014093 |
| concepts[12].level | 1 |
| concepts[12].score | 0.2111981213092804 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q101929 |
| concepts[12].display_name | Immunology |
| concepts[13].id | https://openalex.org/C54009773 |
| concepts[13].level | 3 |
| concepts[13].score | 0.0917319655418396 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q1429031 |
| concepts[13].display_name | Transfection |
| concepts[14].id | https://openalex.org/C104317684 |
| concepts[14].level | 2 |
| concepts[14].score | 0.06733205914497375 |
| concepts[14].wikidata | https://www.wikidata.org/wiki/Q7187 |
| concepts[14].display_name | Gene |
| keywords[0].id | https://openalex.org/keywords/occludin |
| keywords[0].score | 0.904029130935669 |
| keywords[0].display_name | Occludin |
| keywords[1].id | https://openalex.org/keywords/oxidative-stress |
| keywords[1].score | 0.8270921111106873 |
| keywords[1].display_name | Oxidative stress |
| keywords[2].id | https://openalex.org/keywords/cell-biology |
| keywords[2].score | 0.7486316561698914 |
| keywords[2].display_name | Cell biology |
| keywords[3].id | https://openalex.org/keywords/inflammation |
| keywords[3].score | 0.6735954284667969 |
| keywords[3].display_name | Inflammation |
| keywords[4].id | https://openalex.org/keywords/signal-transduction |
| keywords[4].score | 0.6534854769706726 |
| keywords[4].display_name | Signal transduction |
| keywords[5].id | https://openalex.org/keywords/small-interfering-rna |
| keywords[5].score | 0.6441879272460938 |
| keywords[5].display_name | Small interfering RNA |
| keywords[6].id | https://openalex.org/keywords/gene-silencing |
| keywords[6].score | 0.6292216181755066 |
| keywords[6].display_name | Gene silencing |
| keywords[7].id | https://openalex.org/keywords/chemistry |
| keywords[7].score | 0.5178033113479614 |
| keywords[7].display_name | Chemistry |
| keywords[8].id | https://openalex.org/keywords/tight-junction |
| keywords[8].score | 0.46711692214012146 |
| keywords[8].display_name | Tight junction |
| keywords[9].id | https://openalex.org/keywords/antioxidant |
| keywords[9].score | 0.41543465852737427 |
| keywords[9].display_name | Antioxidant |
| keywords[10].id | https://openalex.org/keywords/biology |
| keywords[10].score | 0.2822284698486328 |
| keywords[10].display_name | Biology |
| keywords[11].id | https://openalex.org/keywords/biochemistry |
| keywords[11].score | 0.21687942743301392 |
| keywords[11].display_name | Biochemistry |
| keywords[12].id | https://openalex.org/keywords/immunology |
| keywords[12].score | 0.2111981213092804 |
| keywords[12].display_name | Immunology |
| keywords[13].id | https://openalex.org/keywords/transfection |
| keywords[13].score | 0.0917319655418396 |
| keywords[13].display_name | Transfection |
| keywords[14].id | https://openalex.org/keywords/gene |
| keywords[14].score | 0.06733205914497375 |
| keywords[14].display_name | Gene |
| language | en |
| locations[0].id | doi:10.3390/antiox13050533 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S2737566431 |
| locations[0].source.issn | 2076-3921 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 2076-3921 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | Antioxidants |
| locations[0].source.host_organization | https://openalex.org/P4310310987 |
| locations[0].source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310310987 |
| locations[0].license | cc-by |
| locations[0].pdf_url | https://www.mdpi.com/2076-3921/13/5/533/pdf?version=1714184813 |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Antioxidants |
| locations[0].landing_page_url | https://doi.org/10.3390/antiox13050533 |
| locations[1].id | pmid:38790638 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Antioxidants (Basel, Switzerland) |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/38790638 |
| locations[2].id | pmh:oai:pubmedcentral.nih.gov:11117695 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S2764455111 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | PubMed Central |
| locations[2].source.host_organization | https://openalex.org/I1299303238 |
| locations[2].source.host_organization_name | National Institutes of Health |
| locations[2].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[2].license | other-oa |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | https://openalex.org/licenses/other-oa |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | Antioxidants (Basel) |
| locations[2].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/11117695 |
| locations[3].id | pmh:oai:doaj.org/article:eec4e46e63ca4f04b0989a03e67dd5a7 |
| locations[3].is_oa | False |
| locations[3].source.id | https://openalex.org/S4306401280 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | False |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | DOAJ (DOAJ: Directory of Open Access Journals) |
| locations[3].source.host_organization | |
| locations[3].source.host_organization_name | |
| locations[3].source.host_organization_lineage | |
| locations[3].license | |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | article |
| locations[3].license_id | |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | Antioxidants, Vol 13, Iss 5, p 533 (2024) |
| locations[3].landing_page_url | https://doaj.org/article/eec4e46e63ca4f04b0989a03e67dd5a7 |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5091476985 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-6098-1205 |
| authorships[0].author.display_name | Cheng Shen |
| authorships[0].countries | CN |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I183067930 |
| authorships[0].affiliations[0].raw_affiliation_string | Shanghai Key Laboratory of Veterinary Biotechnology/Shanghai Collaborative Innovation Center of Agri-Seeds, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China |
| authorships[0].institutions[0].id | https://openalex.org/I183067930 |
| authorships[0].institutions[0].ror | https://ror.org/0220qvk04 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I183067930 |
| authorships[0].institutions[0].country_code | CN |
| authorships[0].institutions[0].display_name | Shanghai Jiao Tong University |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Cheng Shen |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Shanghai Key Laboratory of Veterinary Biotechnology/Shanghai Collaborative Innovation Center of Agri-Seeds, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China |
| authorships[1].author.id | https://openalex.org/A5021394088 |
| authorships[1].author.orcid | https://orcid.org/0000-0002-1142-2845 |
| authorships[1].author.display_name | Zhen Luo |
| authorships[1].countries | CN |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I183067930 |
| authorships[1].affiliations[0].raw_affiliation_string | Shanghai Key Laboratory of Veterinary Biotechnology/Shanghai Collaborative Innovation Center of Agri-Seeds, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China |
| authorships[1].institutions[0].id | https://openalex.org/I183067930 |
| authorships[1].institutions[0].ror | https://ror.org/0220qvk04 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I183067930 |
| authorships[1].institutions[0].country_code | CN |
| authorships[1].institutions[0].display_name | Shanghai Jiao Tong University |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Zhen Luo |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Shanghai Key Laboratory of Veterinary Biotechnology/Shanghai Collaborative Innovation Center of Agri-Seeds, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China |
| authorships[2].author.id | https://openalex.org/A5009988281 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-2843-7795 |
| authorships[2].author.display_name | Sheng Ma |
| authorships[2].countries | CN |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I183067930 |
| authorships[2].affiliations[0].raw_affiliation_string | Shanghai Key Laboratory of Veterinary Biotechnology/Shanghai Collaborative Innovation Center of Agri-Seeds, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China |
| authorships[2].institutions[0].id | https://openalex.org/I183067930 |
| authorships[2].institutions[0].ror | https://ror.org/0220qvk04 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I183067930 |
| authorships[2].institutions[0].country_code | CN |
| authorships[2].institutions[0].display_name | Shanghai Jiao Tong University |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Sheng Ma |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Shanghai Key Laboratory of Veterinary Biotechnology/Shanghai Collaborative Innovation Center of Agri-Seeds, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China |
| authorships[3].author.id | https://openalex.org/A5009490237 |
| authorships[3].author.orcid | https://orcid.org/0000-0001-8255-9243 |
| authorships[3].author.display_name | Chengbing Yu |
| authorships[3].countries | CN |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I183067930 |
| authorships[3].affiliations[0].raw_affiliation_string | Shanghai Key Laboratory of Veterinary Biotechnology/Shanghai Collaborative Innovation Center of Agri-Seeds, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China |
| authorships[3].institutions[0].id | https://openalex.org/I183067930 |
| authorships[3].institutions[0].ror | https://ror.org/0220qvk04 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I183067930 |
| authorships[3].institutions[0].country_code | CN |
| authorships[3].institutions[0].display_name | Shanghai Jiao Tong University |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Chengbing Yu |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Shanghai Key Laboratory of Veterinary Biotechnology/Shanghai Collaborative Innovation Center of Agri-Seeds, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China |
| authorships[4].author.id | https://openalex.org/A5060344804 |
| authorships[4].author.orcid | |
| authorships[4].author.display_name | Ting Lai |
| authorships[4].countries | CN |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I183067930 |
| authorships[4].affiliations[0].raw_affiliation_string | Shanghai Key Laboratory of Veterinary Biotechnology/Shanghai Collaborative Innovation Center of Agri-Seeds, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China |
| authorships[4].institutions[0].id | https://openalex.org/I183067930 |
| authorships[4].institutions[0].ror | https://ror.org/0220qvk04 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I183067930 |
| authorships[4].institutions[0].country_code | CN |
| authorships[4].institutions[0].display_name | Shanghai Jiao Tong University |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Ting Lai |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Shanghai Key Laboratory of Veterinary Biotechnology/Shanghai Collaborative Innovation Center of Agri-Seeds, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China |
| authorships[5].author.id | https://openalex.org/A5091813508 |
| authorships[5].author.orcid | |
| authorships[5].author.display_name | Shangshang Tang |
| authorships[5].countries | CN |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I183067930 |
| authorships[5].affiliations[0].raw_affiliation_string | Shanghai Key Laboratory of Veterinary Biotechnology/Shanghai Collaborative Innovation Center of Agri-Seeds, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China |
| authorships[5].institutions[0].id | https://openalex.org/I183067930 |
| authorships[5].institutions[0].ror | https://ror.org/0220qvk04 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I183067930 |
| authorships[5].institutions[0].country_code | CN |
| authorships[5].institutions[0].display_name | Shanghai Jiao Tong University |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Shangshang Tang |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Shanghai Key Laboratory of Veterinary Biotechnology/Shanghai Collaborative Innovation Center of Agri-Seeds, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China |
| authorships[6].author.id | https://openalex.org/A5101776176 |
| authorships[6].author.orcid | https://orcid.org/0000-0002-9769-463X |
| authorships[6].author.display_name | Hongcai Zhang |
| authorships[6].countries | CN |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I183067930 |
| authorships[6].affiliations[0].raw_affiliation_string | Shanghai Key Laboratory of Veterinary Biotechnology/Shanghai Collaborative Innovation Center of Agri-Seeds, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China |
| authorships[6].institutions[0].id | https://openalex.org/I183067930 |
| authorships[6].institutions[0].ror | https://ror.org/0220qvk04 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I183067930 |
| authorships[6].institutions[0].country_code | CN |
| authorships[6].institutions[0].display_name | Shanghai Jiao Tong University |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Hongcai Zhang |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Shanghai Key Laboratory of Veterinary Biotechnology/Shanghai Collaborative Innovation Center of Agri-Seeds, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China |
| authorships[7].author.id | https://openalex.org/A5100345440 |
| authorships[7].author.orcid | https://orcid.org/0000-0002-8449-6554 |
| authorships[7].author.display_name | Jing Zhang |
| authorships[7].countries | CN |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I183067930 |
| authorships[7].affiliations[0].raw_affiliation_string | Shanghai Key Laboratory of Veterinary Biotechnology/Shanghai Collaborative Innovation Center of Agri-Seeds, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China |
| authorships[7].institutions[0].id | https://openalex.org/I183067930 |
| authorships[7].institutions[0].ror | https://ror.org/0220qvk04 |
| authorships[7].institutions[0].type | education |
| authorships[7].institutions[0].lineage | https://openalex.org/I183067930 |
| authorships[7].institutions[0].country_code | CN |
| authorships[7].institutions[0].display_name | Shanghai Jiao Tong University |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Jing Zhang |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Shanghai Key Laboratory of Veterinary Biotechnology/Shanghai Collaborative Innovation Center of Agri-Seeds, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China |
| authorships[8].author.id | https://openalex.org/A5101947159 |
| authorships[8].author.orcid | https://orcid.org/0000-0003-1432-0083 |
| authorships[8].author.display_name | Weina Xu |
| authorships[8].countries | CN |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I183067930 |
| authorships[8].affiliations[0].raw_affiliation_string | Shanghai Key Laboratory of Veterinary Biotechnology/Shanghai Collaborative Innovation Center of Agri-Seeds, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China |
| authorships[8].institutions[0].id | https://openalex.org/I183067930 |
| authorships[8].institutions[0].ror | https://ror.org/0220qvk04 |
| authorships[8].institutions[0].type | education |
| authorships[8].institutions[0].lineage | https://openalex.org/I183067930 |
| authorships[8].institutions[0].country_code | CN |
| authorships[8].institutions[0].display_name | Shanghai Jiao Tong University |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Weina Xu |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Shanghai Key Laboratory of Veterinary Biotechnology/Shanghai Collaborative Innovation Center of Agri-Seeds, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China |
| authorships[9].author.id | https://openalex.org/A5047470719 |
| authorships[9].author.orcid | https://orcid.org/0000-0003-2026-3791 |
| authorships[9].author.display_name | Jianxiong Xu |
| authorships[9].countries | CN |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I183067930 |
| authorships[9].affiliations[0].raw_affiliation_string | Shanghai Key Laboratory of Veterinary Biotechnology/Shanghai Collaborative Innovation Center of Agri-Seeds, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China |
| authorships[9].institutions[0].id | https://openalex.org/I183067930 |
| authorships[9].institutions[0].ror | https://ror.org/0220qvk04 |
| authorships[9].institutions[0].type | education |
| authorships[9].institutions[0].lineage | https://openalex.org/I183067930 |
| authorships[9].institutions[0].country_code | CN |
| authorships[9].institutions[0].display_name | Shanghai Jiao Tong University |
| authorships[9].author_position | last |
| authorships[9].raw_author_name | Jianxiong Xu |
| authorships[9].is_corresponding | True |
| authorships[9].raw_affiliation_strings | Shanghai Key Laboratory of Veterinary Biotechnology/Shanghai Collaborative Innovation Center of Agri-Seeds, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China |
| has_content.pdf | True |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.mdpi.com/2076-3921/13/5/533/pdf?version=1714184813 |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2024-05-02T00:00:00 |
| display_name | Microbe-Derived Antioxidants Protect IPEC-1 Cells from H2O2-Induced Oxidative Stress, Inflammation and Tight Junction Protein Disruption via Activating the Nrf2 Pathway to Inhibit the ROS/NLRP3/IL-1β Signaling Pathway |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T12020 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 0.9789000153541565 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2746 |
| primary_topic.subfield.display_name | Surgery |
| primary_topic.display_name | Enhanced Recovery After Surgery |
| related_works | https://openalex.org/W328094162, https://openalex.org/W2581100459, https://openalex.org/W1267894645, https://openalex.org/W2187837306, https://openalex.org/W2384563134, https://openalex.org/W2033176166, https://openalex.org/W4280529994, https://openalex.org/W2125640458, https://openalex.org/W1996227425, https://openalex.org/W2091060133 |
| cited_by_count | 9 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 7 |
| counts_by_year[1].year | 2024 |
| counts_by_year[1].cited_by_count | 2 |
| locations_count | 4 |
| best_oa_location.id | doi:10.3390/antiox13050533 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S2737566431 |
| best_oa_location.source.issn | 2076-3921 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 2076-3921 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | Antioxidants |
| best_oa_location.source.host_organization | https://openalex.org/P4310310987 |
| best_oa_location.source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310310987 |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | https://www.mdpi.com/2076-3921/13/5/533/pdf?version=1714184813 |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Antioxidants |
| best_oa_location.landing_page_url | https://doi.org/10.3390/antiox13050533 |
| primary_location.id | doi:10.3390/antiox13050533 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S2737566431 |
| primary_location.source.issn | 2076-3921 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 2076-3921 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | Antioxidants |
| primary_location.source.host_organization | https://openalex.org/P4310310987 |
| primary_location.source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310310987 |
| primary_location.license | cc-by |
| primary_location.pdf_url | https://www.mdpi.com/2076-3921/13/5/533/pdf?version=1714184813 |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Antioxidants |
| primary_location.landing_page_url | https://doi.org/10.3390/antiox13050533 |
| publication_date | 2024-04-27 |
| publication_year | 2024 |
| referenced_works | https://openalex.org/W2885800801, https://openalex.org/W4319459332, https://openalex.org/W2996372803, https://openalex.org/W2889565370, https://openalex.org/W4210809403, https://openalex.org/W4282947191, https://openalex.org/W2048032544, https://openalex.org/W3136190145, https://openalex.org/W2905700552, https://openalex.org/W2753995352, https://openalex.org/W2726689938, https://openalex.org/W3015964730, https://openalex.org/W3177486027, https://openalex.org/W4210726984, https://openalex.org/W2992093355, https://openalex.org/W4319600844, https://openalex.org/W3002300102, https://openalex.org/W2991339604, https://openalex.org/W2943293743, https://openalex.org/W2014054401, https://openalex.org/W3045978268, https://openalex.org/W3213927789, https://openalex.org/W2557633607, https://openalex.org/W2888059941, https://openalex.org/W2949728293, https://openalex.org/W4379094370, https://openalex.org/W4379618550, https://openalex.org/W4220661897, https://openalex.org/W4353094016, https://openalex.org/W2613251895, https://openalex.org/W3217538343 |
| referenced_works_count | 31 |
| abstract_inverted_index.1 | 120, 125 |
| abstract_inverted_index.a | 28, 270 |
| abstract_inverted_index.(1 | 99 |
| abstract_inverted_index.12 | 112 |
| abstract_inverted_index.In | 35, 185 |
| abstract_inverted_index.MA | 192 |
| abstract_inverted_index.We | 127 |
| abstract_inverted_index.an | 291, 330 |
| abstract_inverted_index.as | 144 |
| abstract_inverted_index.be | 241 |
| abstract_inverted_index.by | 76, 91, 153, 161, 180, 391 |
| abstract_inverted_index.h, | 113 |
| abstract_inverted_index.h. | 126 |
| abstract_inverted_index.in | 9, 32, 48, 199, 269, 293, 325, 344, 384 |
| abstract_inverted_index.is | 15, 389 |
| abstract_inverted_index.it | 188 |
| abstract_inverted_index.mM | 121 |
| abstract_inverted_index.of | 13, 22, 59, 67, 87, 109, 137, 213, 222, 236, 258, 273, 283, 296, 309, 320, 328, 332, 339, 358, 378, 400 |
| abstract_inverted_index.or | 182 |
| abstract_inverted_index.to | 17, 63, 69, 78, 83, 106, 119, 133, 240, 370 |
| abstract_inverted_index.we | 39 |
| abstract_inverted_index.× | 100 |
| abstract_inverted_index.100 | 107 |
| abstract_inverted_index.104 | 101 |
| abstract_inverted_index.MAs | 68, 110, 237, 254, 321, 340, 366 |
| abstract_inverted_index.RNA | 131 |
| abstract_inverted_index.ROS | 158, 208 |
| abstract_inverted_index.The | 11, 56, 164, 317, 334 |
| abstract_inverted_index.aim | 58 |
| abstract_inverted_index.and | 5, 53, 82, 139, 146, 171, 176, 205, 216, 218, 224, 276, 302, 336, 341, 376 |
| abstract_inverted_index.can | 2 |
| abstract_inverted_index.for | 111, 124 |
| abstract_inverted_index.its | 261 |
| abstract_inverted_index.our | 36, 186 |
| abstract_inverted_index.the | 20, 23, 33, 65, 85, 93, 135, 196, 211, 220, 228, 233, 244, 251, 256, 264, 281, 284, 294, 307, 313, 326, 359, 368, 393, 398, 401 |
| abstract_inverted_index.was | 62, 159, 189, 238, 290, 322 |
| abstract_inverted_index.ASC, | 215 |
| abstract_inverted_index.CAT, | 303 |
| abstract_inverted_index.H2O2 | 122 |
| abstract_inverted_index.HO-1 | 277 |
| abstract_inverted_index.Nrf2 | 360, 402 |
| abstract_inverted_index.ROS, | 310 |
| abstract_inverted_index.SFN, | 329 |
| abstract_inverted_index.SOD, | 300 |
| abstract_inverted_index.This | 266, 387 |
| abstract_inverted_index.ZO-1 | 223 |
| abstract_inverted_index.both | 50 |
| abstract_inverted_index.from | 72 |
| abstract_inverted_index.gene | 230 |
| abstract_inverted_index.have | 367 |
| abstract_inverted_index.into | 263 |
| abstract_inverted_index.like | 299 |
| abstract_inverted_index.main | 57 |
| abstract_inverted_index.mg/L | 108 |
| abstract_inverted_index.role | 343 |
| abstract_inverted_index.such | 143 |
| abstract_inverted_index.that | 41, 191, 250, 365 |
| abstract_inverted_index.they | 116 |
| abstract_inverted_index.this | 60 |
| abstract_inverted_index.were | 103, 117, 151, 178, 352 |
| abstract_inverted_index.with | 19, 231, 243, 253, 280 |
| abstract_inverted_index.(MAs) | 44 |
| abstract_inverted_index.(ZO-1 | 175 |
| abstract_inverted_index.After | 226 |
| abstract_inverted_index.H2O2, | 77 |
| abstract_inverted_index.NLRP3 | 138, 229, 245 |
| abstract_inverted_index.NQO1, | 275 |
| abstract_inverted_index.Nrf2, | 259, 274 |
| abstract_inverted_index.Nrf2. | 140, 333 |
| abstract_inverted_index.These | 362 |
| abstract_inverted_index.after | 114, 355 |
| abstract_inverted_index.along | 279 |
| abstract_inverted_index.cells | 71, 98 |
| abstract_inverted_index.found | 40 |
| abstract_inverted_index.gene. | 361 |
| abstract_inverted_index.point | 31 |
| abstract_inverted_index.siRNA | 356 |
| abstract_inverted_index.small | 129 |
| abstract_inverted_index.their | 342 |
| abstract_inverted_index.there | 289 |
| abstract_inverted_index.tight | 6, 88, 172, 348, 381 |
| abstract_inverted_index.which | 115, 304 |
| abstract_inverted_index.ELISA. | 154 |
| abstract_inverted_index.IL-1β | 145 |
| abstract_inverted_index.IPEC-1 | 97, 385 |
| abstract_inverted_index.NLRP3, | 214 |
| abstract_inverted_index.caused | 75 |
| abstract_inverted_index.cells. | 386 |
| abstract_inverted_index.enzyme | 148 |
| abstract_inverted_index.induce | 3 |
| abstract_inverted_index.levels | 150 |
| abstract_inverted_index.linked | 242 |
| abstract_inverted_index.marker | 157 |
| abstract_inverted_index.reduce | 79, 371 |
| abstract_inverted_index.showed | 45 |
| abstract_inverted_index.siRNA, | 232 |
| abstract_inverted_index.state. | 316 |
| abstract_inverted_index.stress | 1, 74, 156, 315 |
| abstract_inverted_index.(siRNA) | 132 |
| abstract_inverted_index.GSH-Px, | 301 |
| abstract_inverted_index.IL-18), | 206 |
| abstract_inverted_index.IL-1β, | 204 |
| abstract_inverted_index.RT-qPCR | 181 |
| abstract_inverted_index.Western | 183 |
| abstract_inverted_index.ability | 66 |
| abstract_inverted_index.crucial | 29 |
| abstract_inverted_index.enzymes | 298 |
| abstract_inverted_index.exposed | 105 |
| abstract_inverted_index.factors | 142 |
| abstract_inverted_index.inhibit | 134 |
| abstract_inverted_index.markers | 202 |
| abstract_inverted_index.marking | 27 |
| abstract_inverted_index.notable | 197, 271 |
| abstract_inverted_index.pathway | 170, 396 |
| abstract_inverted_index.process | 267 |
| abstract_inverted_index.protect | 70 |
| abstract_inverted_index.protein | 350 |
| abstract_inverted_index.stress, | 374 |
| abstract_inverted_index.suggest | 364 |
| abstract_inverted_index.thereby | 311 |
| abstract_inverted_index.thought | 16 |
| abstract_inverted_index.through | 397 |
| abstract_inverted_index.(TNF-α, | 203 |
| abstract_inverted_index.achieved | 390 |
| abstract_inverted_index.activity | 149 |
| abstract_inverted_index.affected | 354 |
| abstract_inverted_index.blocking | 392 |
| abstract_inverted_index.commence | 18 |
| abstract_inverted_index.detected | 152, 179 |
| abstract_inverted_index.effects. | 55 |
| abstract_inverted_index.examined | 160 |
| abstract_inverted_index.findings | 363 |
| abstract_inverted_index.increase | 198 |
| abstract_inverted_index.junction | 7, 89, 173, 349, 382 |
| abstract_inverted_index.maintain | 84 |
| abstract_inverted_index.nucleus. | 265 |
| abstract_inverted_index.observed | 190, 239 |
| abstract_inverted_index.pathway, | 26, 167 |
| abstract_inverted_index.pathway. | 96, 287, 403 |
| abstract_inverted_index.presence | 327 |
| abstract_inverted_index.previous | 37 |
| abstract_inverted_index.process. | 34 |
| abstract_inverted_index.promoted | 219 |
| abstract_inverted_index.proteins | 90, 174, 383 |
| abstract_inverted_index.research | 61 |
| abstract_inverted_index.resulted | 268 |
| abstract_inverted_index.starting | 30 |
| abstract_inverted_index.studies, | 38 |
| abstract_inverted_index.utilized | 128 |
| abstract_inverted_index.Nrf2-HO-1 | 285 |
| abstract_inverted_index.Nrf2/HO-1 | 168 |
| abstract_inverted_index.Occludin) | 177 |
| abstract_inverted_index.Occludin. | 225 |
| abstract_inverted_index.Oxidative | 0, 155 |
| abstract_inverted_index.activator | 331 |
| abstract_inverted_index.analysis. | 163 |
| abstract_inverted_index.blotting. | 184 |
| abstract_inverted_index.decreased | 207 |
| abstract_inverted_index.enhancing | 49 |
| abstract_inverted_index.functions | 338 |
| abstract_inverted_index.influence | 235 |
| abstract_inverted_index.initially | 104 |
| abstract_inverted_index.integrity | 86 |
| abstract_inverted_index.knockdown | 357 |
| abstract_inverted_index.mitigated | 210, 306 |
| abstract_inverted_index.oxidative | 73, 314, 373 |
| abstract_inverted_index.potential | 47, 369 |
| abstract_inverted_index.reduction | 388 |
| abstract_inverted_index.research, | 187 |
| abstract_inverted_index.signaling | 25, 95, 166, 169, 286, 395 |
| abstract_inverted_index.silencing | 227 |
| abstract_inverted_index.subjected | 118 |
| abstract_inverted_index.treatment | 123, 193, 252 |
| abstract_inverted_index.triggered | 255 |
| abstract_inverted_index.Additional | 247 |
| abstract_inverted_index.activation | 21, 257, 399 |
| abstract_inverted_index.activities | 295 |
| abstract_inverted_index.caspase-1, | 217 |
| abstract_inverted_index.disruption | 8, 351, 377 |
| abstract_inverted_index.epithelial | 347, 380 |
| abstract_inverted_index.expression | 136, 212, 221 |
| abstract_inverted_index.heightened | 324 |
| abstract_inverted_index.initiation | 12, 282 |
| abstract_inverted_index.intestinal | 346, 379 |
| abstract_inverted_index.modulating | 92 |
| abstract_inverted_index.protective | 234 |
| abstract_inverted_index.regulating | 345 |
| abstract_inverted_index.responses, | 81 |
| abstract_inverted_index.suppressed | 195 |
| abstract_inverted_index.antioxidant | 51, 147, 297, 318, 335 |
| abstract_inverted_index.cells/well) | 102 |
| abstract_inverted_index.effectively | 194, 305 |
| abstract_inverted_index.enhancement | 292 |
| abstract_inverted_index.expression, | 278 |
| abstract_inverted_index.interfering | 130 |
| abstract_inverted_index.investigate | 64 |
| abstract_inverted_index.significant | 46 |
| abstract_inverted_index.H2O2-induced | 200 |
| abstract_inverted_index.Inflammatory | 141 |
| abstract_inverted_index.NLRP3/IL-1β | 165 |
| abstract_inverted_index.accumulation | 308 |
| abstract_inverted_index.additionally | 323 |
| abstract_inverted_index.ameliorating | 312 |
| abstract_inverted_index.antioxidants | 43 |
| abstract_inverted_index.capabilities | 52 |
| abstract_inverted_index.demonstrated | 249 |
| abstract_inverted_index.enterocytes. | 10 |
| abstract_inverted_index.facilitating | 260 |
| abstract_inverted_index.fluorescence | 162 |
| abstract_inverted_index.inflammation | 4, 14 |
| abstract_inverted_index.inflammatory | 80, 201 |
| abstract_inverted_index.upregulation | 272 |
| abstract_inverted_index.Consequently, | 288 |
| abstract_inverted_index.accumulation, | 209 |
| abstract_inverted_index.effectiveness | 319 |
| abstract_inverted_index.inflammasome. | 246 |
| abstract_inverted_index.inflammation, | 375 |
| abstract_inverted_index.significantly | 353 |
| abstract_inverted_index.translocation | 262 |
| abstract_inverted_index.H2O2-triggered | 372 |
| abstract_inverted_index.investigations | 248 |
| abstract_inverted_index.microbe-derived | 42 |
| abstract_inverted_index.ROS/NLRP3/IL-1β | 24, 94, 394 |
| abstract_inverted_index.anti-inflammatory | 54, 337 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 94 |
| corresponding_author_ids | https://openalex.org/A5047470719 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 10 |
| corresponding_institution_ids | https://openalex.org/I183067930 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/6 |
| sustainable_development_goals[0].score | 0.46000000834465027 |
| sustainable_development_goals[0].display_name | Clean water and sanitation |
| citation_normalized_percentile.value | 0.97322 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |