Microbial functional pathways based on metatranscriptomic profiling enable effective saliva-based health assessments for precision wellness Article Swipe

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Eric Patridge , Anmol Gorakshakar , Matthew M. Molusky , Oyetunji Ogundijo , Angel Janevski , Cristina Julián , Lan Hu , Momchilo Vuyisich , Guruduth Banavar ·

YOU? · · 2024 · Open Access · · DOI: https://doi.org/10.1016/j.csbj.2024.01.018

It is increasingly recognized that an important step towards improving overall health is to accurately measure biomarkers of health from the molecular activities prevalent in the oral cavity. We present a general methodology for computationally quantifying the activity of microbial functional pathways using metatranscriptomic data. We describe their implementation as a collection of eight oral pathway scores using a large salivary sample dataset (n = 9350), and we evaluate score associations with oropharyngeal disease phenotypes within an unseen independent cohort (n = 14,129). Through this validation, we show that the relevant oral pathway scores are significantly worse in individuals with periodontal disease, acid reflux, and nicotine addiction, compared with controls. Given these associations, we make the case to use these oral pathway scores to provide molecular health insights from simple, non-invasive saliva samples, and as molecular endpoints for actionable interventions to address the associated conditions.

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Computational Biology

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Saliva Medicine Psychological intervention Lubiprostone Oral cavity Disease Cohort Oral health Bioinformatics Computational biology Internal medicine Biology Dentistry Psychiatry Chronic constipation Constipation

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Type: article
Language: en
Landing Page: https://doi.org/10.1016/j.csbj.2024.01.018
PDF: http://www.csbj.org/article/S2001037024000199/pdf
OA Status: gold
Cited By: 4
References: 139
Related Works: 10
OpenAlex ID: https://openalex.org/W4391310800

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DOI: https://doi.org/10.1016/j.csbj.2024.01.018

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Title: Microbial functional pathways based on metatranscriptomic profiling enable effective saliva-based health assessments for precision wellness

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Language: en

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Publication year: 2024

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Publication date: 2024-01-29

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Authors: Eric Patridge, Anmol Gorakshakar, Matthew M. Molusky, Oyetunji Ogundijo, Angel Janevski, Cristina Julián, Lan Hu, Momchilo Vuyisich, Guruduth Banavar

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Landing page: https://doi.org/10.1016/j.csbj.2024.01.018

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Concepts: Saliva, Medicine, Psychological intervention, Lubiprostone, Oral cavity, Disease, Cohort, Oral health, Bioinformatics, Computational biology, Internal medicine, Biology, Dentistry, Psychiatry, Chronic constipation, Constipation

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Cited by: 4

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Citations by year (recent): 2025: 2, 2024: 2

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