Microfluidic-Assisted Preparation of 5-Fluorouracil-Loaded PLGA Nanoparticles as a Potential System for Colorectal Cancer Therapy Article Swipe

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Mahtab Ghasemi Toudeshkchouei , Payam Zahedi , Amin Shavandi ·

YOU? · · 2020 · Open Access · · DOI: https://doi.org/10.3390/ma13071483

This work aims at fabricating 5-fluorouracil (5-FU)-loaded poly (lactic-co-glycolic) acid nanoparticles (PLGA NPs) using a microfluidic (MF) technique, with potential for use in colorectal cancer therapy. In order to achieve 5-FU-loaded NPs with an average diameter of approximately 119 nm, the parameters of MF process with fork-shaped patterns were adjusted as follows: the ratio of polymer to drug solutions flow rates was equal to 10 and the solution concentrations of PLGA as carrier, 5-FU as anti-cancer drug and poly (vinyl alcohol) (PVA) as surfactant were 0.2 (% w/v), 0.01 (% w/v) and 0.15 (% w/v), respectively. In this way, a drug encapsulation efficiency of approximately 95% into the PLGA NPs was obtained, due to the formation of a hydrodynamic flow focusing phenomenon through the MF chip. A performance evaluation of the NP samples in terms of the drug release, cytotoxicity and cell death was carried out. Finally, by analyzing the results after induction of cell death and 4′, 6-diamidino-2-phenylin-dole (DAPI) staining, MF-fabricated NPs containing 5-FU [0.2 (% w/v) of PLGA] revealed the dead cell amounts of 10 and 1.5-fold higher than the control sample for Caco2 and SW-480, respectively.

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Biomedical Engineering

Concepts

PLGA DAPI Materials science Glycolic acid Pulmonary surfactant Nanoparticle Fluorouracil Drug delivery Cytotoxicity Drug carrier Colorectal cancer Nuclear chemistry Nanotechnology Biomedical engineering Chemistry Lactic acid In vitro Cancer Surgery Medicine Biochemistry Chemotherapy Genetics Biology Apoptosis Internal medicine Bacteria

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Type: article
Language: en
Landing Page: https://doi.org/10.3390/ma13071483
PDF: https://www.mdpi.com/1996-1944/13/7/1483/pdf?version=1585321306
OA Status: gold
Cited By: 33
References: 48
Related Works: 10
OpenAlex ID: https://openalex.org/W3013281133

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DOI: https://doi.org/10.3390/ma13071483

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Title: Microfluidic-Assisted Preparation of 5-Fluorouracil-Loaded PLGA Nanoparticles as a Potential System for Colorectal Cancer Therapy

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Type: article

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Language: en

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Publication year: 2020

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Publication date: 2020-03-25

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Authors: Mahtab Ghasemi Toudeshkchouei, Payam Zahedi, Amin Shavandi

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Landing page: https://doi.org/10.3390/ma13071483

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PDF URL: https://www.mdpi.com/1996-1944/13/7/1483/pdf?version=1585321306

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Concepts: PLGA, DAPI, Materials science, Glycolic acid, Pulmonary surfactant, Nanoparticle, Fluorouracil, Drug delivery, Cytotoxicity, Drug carrier, Colorectal cancer, Nuclear chemistry, Nanotechnology, Biomedical engineering, Chemistry, Lactic acid, In vitro, Cancer, Surgery, Medicine, Biochemistry, Chemotherapy, Genetics, Biology, Apoptosis, Internal medicine, Bacteria

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Cited by: 33

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Citations by year (recent): 2025: 9, 2024: 7, 2023: 7, 2022: 7, 2021: 2

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