Microfluidic Channel for Simulating Wall Shear Stress Waveforms in Carotid Bifurcation Blood Flow Article Swipe
Li-Jin Yuan
,
Yong‐Jiang Li
,
Zheng Liu
,
Chun‐Dong Xue
,
Chen Dong
,
Kai‐Rong Qin
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.20944/preprints202402.1333.v1
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.20944/preprints202402.1333.v1
Wall Shear Stress (WSS) abnormalities in carotid artery blood flow are key hemodynamic factors leading to arterial endothelial damage, atherosclerotic plaque formation, and carotid artery stenosis. Precise simulation of carotid artery blood flow WSS in vitro play an important role in understanding the underlying hemodynamic mechanism of carotid artery stenosis. This study presents a design for a microfluidic cell culture chamber with a variable cross-section and a step structure, leveraging microfluidic technology and principles of fluid dynamics. We propose an optimization strategy for microchannel dimensions based on Computational Fluid Dynamics (CFD) simulations. This strategy aims to replicate the distinct WSS waveform features found at various locations within the carotid bifurcation as observed in vivo. Our simulations indicate that with a step height of 0.09 mm, a width of 4 mm for the initial segment, and 5 mm for the subsequent wider channel, the device can effectively model the characteristics of low oscillatory WSS seen at sites of carotid sinus stenosis. Furthermore, it accurately represents the high-magnitude pulsatile WSS waveforms in the more uniform arterial sections downstream of the carotid sinus. The study also reveals that vortex formation and variations in low oscillatory WSS within the stepped section of the microchannel correlate with the step's height and width, as well as with the dimensions of the wider channel section. An increase in step width leads to a decrease in both the vortex area and the magnitude of negative WSS oscillations. When the step height is less than 0.03 mm, vortex formation is inhibited, challenging the simulation of low oscillatory WSS patterns. The variable cross-section microfluidic channel developed in this study provides a platform for simulating carotid artery WSS waveforms and facilitates research into the interplay between low oscillatory WSS at sites of carotid sinus stenosis and arterial endothelial dysfunction.
Related Topics
Concepts
Shear stress
Mechanics
Carotid bifurcation
Bifurcation
Blood flow
Microfluidics
Waveform
Flow (mathematics)
Materials science
Shear (geology)
Channel (broadcasting)
Physics
Carotid arteries
Cardiology
Computer science
Nonlinear system
Engineering
Medicine
Composite material
Nanotechnology
Telecommunications
Electrical engineering
Voltage
Quantum mechanics
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.20944/preprints202402.1333.v1
- https://www.preprints.org/manuscript/202402.1333/v1/download
- OA Status
- green
- Cited By
- 1
- References
- 34
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4392371523
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4392371523Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.20944/preprints202402.1333.v1Digital Object Identifier
- Title
-
Microfluidic Channel for Simulating Wall Shear Stress Waveforms in Carotid Bifurcation Blood FlowWork title
- Type
-
preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-02-22Full publication date if available
- Authors
-
Li-Jin Yuan, Yong‐Jiang Li, Zheng Liu, Chun‐Dong Xue, Chen Dong, Kai‐Rong QinList of authors in order
- Landing page
-
https://doi.org/10.20944/preprints202402.1333.v1Publisher landing page
- PDF URL
-
https://www.preprints.org/manuscript/202402.1333/v1/downloadDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.preprints.org/manuscript/202402.1333/v1/downloadDirect OA link when available
- Concepts
-
Shear stress, Mechanics, Carotid bifurcation, Bifurcation, Blood flow, Microfluidics, Waveform, Flow (mathematics), Materials science, Shear (geology), Channel (broadcasting), Physics, Carotid arteries, Cardiology, Computer science, Nonlinear system, Engineering, Medicine, Composite material, Nanotechnology, Telecommunications, Electrical engineering, Voltage, Quantum mechanicsTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
1Total citation count in OpenAlex
- Citations by year (recent)
-
2024: 1Per-year citation counts (last 5 years)
- References (count)
-
34Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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