Microglia endotoxin tolerance is retained after enforced repopulation Article Swipe
Tiago Medeiros-Furquim
,
Anneke Miedema
,
Edwin Schilder
,
Nieske Brouwer
,
Inge R. Holtman
,
Susanne M. Kooistra
,
Bart J. L. Eggen
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1016/j.bbi.2025.04.014
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1016/j.bbi.2025.04.014
Microglia are crucial for CNS homeostasis and are involved in a wide range of neurodegenerative and neuroinflammatory diseases. Systemic inflammation and infections can contribute to neurodegeneration later in life by affecting microglia. Like other innate immune cells, microglia can develop innate immune memory (IIM) in response to an inflammatory challenge, altering their response to subsequent stimuli. IIM can ameliorate or worsen CNS pathology, but it is unclear if IIM can be reversed to restore microglia functions. Here, we investigated whether microglia depletion-repopulation by inhibition of the colony-stimulating factor 1 receptor with BLZ945 reversed LPS-induced microglia endotoxin tolerance in mice. Repopulated microglia displayed a reduced expression of homeostatic genes and genes related to mitochondrial respiration and TCA cycle metabolism and an increased expression of immune effector and activation genes. Nonetheless, the blunted inflammatory gene response after LPS-preconditioning was retained after a depletion-repopulation cycle. Our study highlights the persistence of endotoxin tolerance in microglia after a depletion-repopulation cycle, which might impact the potential effectiveness of strategies targeted at microglia depletion for clinical applications.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.bbi.2025.04.014
- OA Status
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- References
- 85
- Related Works
- 10
- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W4409685863Canonical identifier for this work in OpenAlex
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https://doi.org/10.1016/j.bbi.2025.04.014Digital Object Identifier
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Microglia endotoxin tolerance is retained after enforced repopulationWork title
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articleOpenAlex work type
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enPrimary language
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2025Year of publication
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2025-04-22Full publication date if available
- Authors
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Tiago Medeiros-Furquim, Anneke Miedema, Edwin Schilder, Nieske Brouwer, Inge R. Holtman, Susanne M. Kooistra, Bart J. L. EggenList of authors in order
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https://doi.org/10.1016/j.bbi.2025.04.014Publisher landing page
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://doi.org/10.1016/j.bbi.2025.04.014Direct OA link when available
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Repopulation, Microglia, Medicine, Intensive care medicine, Immunology, Biology, Inflammation, Cell biology, Stem cell, HaematopoiesisTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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85Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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