MicroRNA-1281 as a Novel Circulating Biomarker in Patients With Diabetic Retinopathy Article Swipe
Marta Greco
,
Eusebio Chiefari
,
Francesca Accattato
,
Domenica Corigliano
,
Biagio Arcidiacono
,
Maria Mirabelli
,
Rossella Liguori
,
Francesco Brunetti
,
Salvatore A. Pullano
,
Vincenzo Scorcia
,
Antonino S. Fiorillo
,
Daniela Foti
,
Antonio Brunetti
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.3389/fendo.2020.00528
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.3389/fendo.2020.00528
Objective: Recently, the role of circulating miRNAs as non-invasive biomarkers for the identification and monitoring of diabetes microvascular complications has emerged. Herein, we aimed to: identify circulating miRNAs differentially expressed in patients with and without diabetic retinopathy (DR); examine their predictive value; and understand their pathogenic impact. Methods: Pooled serum samples from randomly selected matched patients with type 2 diabetes, either with or without DR, were used for initial serum miRNA profiling. Validation of the most relevant miRNAs was thereafter conducted by RT-qPCR in an extended sample of patients with DR and matched controls. Results: Following miRNA profiling, 43 miRNAs were significantly up- or down-regulated in patients with DR compared with controls. After individual validation, 5 miRNAs were found significantly overexpressed in patients with DR. One of them, miR-1281, was the most up-regulated and appeared to be specifically related to DR. Furthermore, secreted levels of miR-1281 were increased in high glucose-cultured retinal cells, and there was evidence of a potential link between glucose-induced miR-1281 up-regulation and DR. Conclusion: Our findings suggest miR-1281 as a circulating biomarker of DR. Also, they highlight the pathogenic significance of miR-1281, providing insights for a new potential target in treating DR.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fendo.2020.00528
- OA Status
- gold
- Cited By
- 52
- References
- 69
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3047048624
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3047048624Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3389/fendo.2020.00528Digital Object Identifier
- Title
-
MicroRNA-1281 as a Novel Circulating Biomarker in Patients With Diabetic RetinopathyWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2020Year of publication
- Publication date
-
2020-08-04Full publication date if available
- Authors
-
Marta Greco, Eusebio Chiefari, Francesca Accattato, Domenica Corigliano, Biagio Arcidiacono, Maria Mirabelli, Rossella Liguori, Francesco Brunetti, Salvatore A. Pullano, Vincenzo Scorcia, Antonino S. Fiorillo, Daniela Foti, Antonio BrunettiList of authors in order
- Landing page
-
https://doi.org/10.3389/fendo.2020.00528Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.3389/fendo.2020.00528Direct OA link when available
- Concepts
-
Biomarker, microRNA, Diabetic retinopathy, Diabetes mellitus, Internal medicine, Biology, Medicine, Type 2 diabetes, Bioinformatics, Endocrinology, Gene, GeneticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
52Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 7, 2024: 6, 2023: 11, 2022: 18, 2021: 9Per-year citation counts (last 5 years)
- References (count)
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69Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| referenced_works | https://openalex.org/W2101508556, https://openalex.org/W2101430875, https://openalex.org/W4244017022, https://openalex.org/W2138480916, https://openalex.org/W1995937915, https://openalex.org/W2142775928, https://openalex.org/W2132892030, https://openalex.org/W144423133, https://openalex.org/W2061998727, https://openalex.org/W2090070787, https://openalex.org/W2111188992, https://openalex.org/W2605314119, https://openalex.org/W2783270596, https://openalex.org/W2075447377, https://openalex.org/W2791525330, https://openalex.org/W2000292756, https://openalex.org/W2562883087, https://openalex.org/W2051477541, https://openalex.org/W2155912199, https://openalex.org/W2153604120, https://openalex.org/W2186449314, https://openalex.org/W2404720093, https://openalex.org/W2030465979, https://openalex.org/W2991603476, https://openalex.org/W2022823113, https://openalex.org/W2156983433, https://openalex.org/W2031843272, https://openalex.org/W4235479662, https://openalex.org/W1966206262, https://openalex.org/W2155965977, https://openalex.org/W4213033871, https://openalex.org/W2079251985, https://openalex.org/W2098067476, https://openalex.org/W2887173830, https://openalex.org/W2982412748, https://openalex.org/W1511249005, https://openalex.org/W2612471636, https://openalex.org/W2578987818, https://openalex.org/W2586708379, https://openalex.org/W2524924266, https://openalex.org/W2605015833, https://openalex.org/W2811387208, https://openalex.org/W2938575397, https://openalex.org/W2900814586, https://openalex.org/W2967802970, https://openalex.org/W2911498362, https://openalex.org/W2948231142, https://openalex.org/W2991409546, https://openalex.org/W3012128960, https://openalex.org/W3009306286, https://openalex.org/W2083890558, https://openalex.org/W2790523805, https://openalex.org/W2575562298, https://openalex.org/W2605955089, https://openalex.org/W2528598919, https://openalex.org/W2044401777, https://openalex.org/W1982754616, https://openalex.org/W2006298215, https://openalex.org/W2011992805, https://openalex.org/W2962609467, https://openalex.org/W2968122044, https://openalex.org/W2980451401, https://openalex.org/W2004368757, https://openalex.org/W2116174813, https://openalex.org/W2001924354, https://openalex.org/W3134431802, https://openalex.org/W2607031541, https://openalex.org/W4234119642, https://openalex.org/W4255176519 |
| referenced_works_count | 69 |
| abstract_inverted_index.2 | 58 |
| abstract_inverted_index.5 | 115 |
| abstract_inverted_index.a | 158, 173, 189 |
| abstract_inverted_index.43 | 98 |
| abstract_inverted_index.DR | 90, 108 |
| abstract_inverted_index.an | 84 |
| abstract_inverted_index.as | 7, 172 |
| abstract_inverted_index.be | 136 |
| abstract_inverted_index.by | 81 |
| abstract_inverted_index.in | 30, 83, 105, 121, 148, 193 |
| abstract_inverted_index.of | 4, 15, 73, 87, 126, 144, 157, 176, 184 |
| abstract_inverted_index.or | 62, 103 |
| abstract_inverted_index.to | 135, 139 |
| abstract_inverted_index.we | 22 |
| abstract_inverted_index.DR, | 64 |
| abstract_inverted_index.DR. | 124, 140, 166, 177, 195 |
| abstract_inverted_index.One | 125 |
| abstract_inverted_index.Our | 168 |
| abstract_inverted_index.and | 13, 33, 42, 91, 133, 153, 165 |
| abstract_inverted_index.for | 10, 67, 188 |
| abstract_inverted_index.has | 19 |
| abstract_inverted_index.new | 190 |
| abstract_inverted_index.the | 2, 11, 74, 130, 181 |
| abstract_inverted_index.to: | 24 |
| abstract_inverted_index.up- | 102 |
| abstract_inverted_index.was | 78, 129, 155 |
| abstract_inverted_index.from | 51 |
| abstract_inverted_index.high | 149 |
| abstract_inverted_index.link | 160 |
| abstract_inverted_index.most | 75, 131 |
| abstract_inverted_index.role | 3 |
| abstract_inverted_index.they | 179 |
| abstract_inverted_index.type | 57 |
| abstract_inverted_index.used | 66 |
| abstract_inverted_index.were | 65, 100, 117, 146 |
| abstract_inverted_index.with | 32, 56, 61, 89, 107, 110, 123 |
| abstract_inverted_index.(DR); | 37 |
| abstract_inverted_index.After | 112 |
| abstract_inverted_index.Also, | 178 |
| abstract_inverted_index.aimed | 23 |
| abstract_inverted_index.found | 118 |
| abstract_inverted_index.miRNA | 70, 96 |
| abstract_inverted_index.serum | 49, 69 |
| abstract_inverted_index.their | 39, 44 |
| abstract_inverted_index.them, | 127 |
| abstract_inverted_index.there | 154 |
| abstract_inverted_index.Pooled | 48 |
| abstract_inverted_index.cells, | 152 |
| abstract_inverted_index.either | 60 |
| abstract_inverted_index.levels | 143 |
| abstract_inverted_index.miRNAs | 6, 27, 77, 99, 116 |
| abstract_inverted_index.sample | 86 |
| abstract_inverted_index.target | 192 |
| abstract_inverted_index.value; | 41 |
| abstract_inverted_index.Herein, | 21 |
| abstract_inverted_index.RT-qPCR | 82 |
| abstract_inverted_index.between | 161 |
| abstract_inverted_index.examine | 38 |
| abstract_inverted_index.impact. | 46 |
| abstract_inverted_index.initial | 68 |
| abstract_inverted_index.matched | 54, 92 |
| abstract_inverted_index.related | 138 |
| abstract_inverted_index.retinal | 151 |
| abstract_inverted_index.samples | 50 |
| abstract_inverted_index.suggest | 170 |
| abstract_inverted_index.without | 34, 63 |
| abstract_inverted_index.appeared | 134 |
| abstract_inverted_index.compared | 109 |
| abstract_inverted_index.diabetes | 16 |
| abstract_inverted_index.diabetic | 35 |
| abstract_inverted_index.emerged. | 20 |
| abstract_inverted_index.evidence | 156 |
| abstract_inverted_index.extended | 85 |
| abstract_inverted_index.findings | 169 |
| abstract_inverted_index.identify | 25 |
| abstract_inverted_index.insights | 187 |
| abstract_inverted_index.patients | 31, 55, 88, 106, 122 |
| abstract_inverted_index.randomly | 52 |
| abstract_inverted_index.relevant | 76 |
| abstract_inverted_index.secreted | 142 |
| abstract_inverted_index.selected | 53 |
| abstract_inverted_index.treating | 194 |
| abstract_inverted_index.Following | 95 |
| abstract_inverted_index.Recently, | 1 |
| abstract_inverted_index.biomarker | 175 |
| abstract_inverted_index.conducted | 80 |
| abstract_inverted_index.controls. | 93, 111 |
| abstract_inverted_index.diabetes, | 59 |
| abstract_inverted_index.expressed | 29 |
| abstract_inverted_index.highlight | 180 |
| abstract_inverted_index.increased | 147 |
| abstract_inverted_index.potential | 159, 191 |
| abstract_inverted_index.providing | 186 |
| abstract_inverted_index.Validation | 72 |
| abstract_inverted_index.biomarkers | 9 |
| abstract_inverted_index.individual | 113 |
| abstract_inverted_index.monitoring | 14 |
| abstract_inverted_index.pathogenic | 45, 182 |
| abstract_inverted_index.predictive | 40 |
| abstract_inverted_index.profiling, | 97 |
| abstract_inverted_index.profiling. | 71 |
| abstract_inverted_index.thereafter | 79 |
| abstract_inverted_index.understand | 43 |
| abstract_inverted_index.circulating | 5, 26, 174 |
| abstract_inverted_index.retinopathy | 36 |
| abstract_inverted_index.validation, | 114 |
| abstract_inverted_index.Furthermore, | 141 |
| abstract_inverted_index.non-invasive | 8 |
| abstract_inverted_index.significance | 183 |
| abstract_inverted_index.specifically | 137 |
| abstract_inverted_index.up-regulated | 132 |
| abstract_inverted_index.complications | 18 |
| abstract_inverted_index.microvascular | 17 |
| abstract_inverted_index.overexpressed | 120 |
| abstract_inverted_index.significantly | 101, 119 |
| abstract_inverted_index.up-regulation | 164 |
| abstract_inverted_index.differentially | 28 |
| abstract_inverted_index.down-regulated | 104 |
| abstract_inverted_index.identification | 12 |
| abstract_inverted_index.<b>Methods:</b> | 47 |
| abstract_inverted_index.<b>Results:</b> | 94 |
| abstract_inverted_index.<i>miR-1281</i> | 145, 163, 171 |
| abstract_inverted_index.glucose-induced | 162 |
| abstract_inverted_index.<i>miR-1281</i>, | 128, 185 |
| abstract_inverted_index.glucose-cultured | 150 |
| abstract_inverted_index.<b>Objective:</b> | 0 |
| abstract_inverted_index.<b>Conclusion:</b> | 167 |
| cited_by_percentile_year.max | 100 |
| cited_by_percentile_year.min | 89 |
| corresponding_author_ids | https://openalex.org/A5076502823 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 13 |
| corresponding_institution_ids | https://openalex.org/I36443711 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.800000011920929 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.93996963 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |