MicroRNAs in the Regulation of RIG-I-like Receptor Signaling Pathway: Possible Strategy for Viral Infection and Cancer Article Swipe
Dengwang Chen
,
Qinglu Ji
,
Jing Liu
,
Feng Cheng
,
Jishan Zheng
,
Yunyan Ma
,
Yuqi He
,
Jidong Zhang
,
Tao Song
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/biom13091344
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/biom13091344
The retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) play a crucial role as pattern-recognition receptors within the innate immune system. These receptors, present in various cell and tissue types, serve as essential sensors for viral infections, enhancing the immune system’s capacity to combat infections through the induction of type I interferons (IFN-I) and inflammatory cytokines. RLRs are involved in a variety of physiological and pathological processes, including viral infections, autoimmune disorders, and cancer. An increasing body of research has examined the possibility of RLRs or microRNAs as therapeutic targets for antiviral infections and malignancies, despite the fact that few studies have focused on the regulatory function of microRNAs on RLR signaling. Consequently, our main emphasis in this review is on elucidating the role of microRNAs in modulating the signaling pathways of RLRs in the context of cancer and viral infections. The aim is to establish a robust knowledge base that can serve as a basis for future comprehensive investigations into the interplay between microRNAs and RIG-I, while also facilitating the advancement of therapeutic drug development.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3390/biom13091344
- https://www.mdpi.com/2218-273X/13/9/1344/pdf?version=1693813277
- OA Status
- gold
- Cited By
- 8
- References
- 162
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4386423631
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Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4386423631Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/biom13091344Digital Object Identifier
- Title
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MicroRNAs in the Regulation of RIG-I-like Receptor Signaling Pathway: Possible Strategy for Viral Infection and CancerWork title
- Type
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reviewOpenAlex work type
- Language
-
enPrimary language
- Publication year
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2023Year of publication
- Publication date
-
2023-09-04Full publication date if available
- Authors
-
Dengwang Chen, Qinglu Ji, Jing Liu, Feng Cheng, Jishan Zheng, Yunyan Ma, Yuqi He, Jidong Zhang, Tao SongList of authors in order
- Landing page
-
https://doi.org/10.3390/biom13091344Publisher landing page
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https://www.mdpi.com/2218-273X/13/9/1344/pdf?version=1693813277Direct link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.mdpi.com/2218-273X/13/9/1344/pdf?version=1693813277Direct OA link when available
- Concepts
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microRNA, Viral infection, Cancer, Signal transduction, Biology, Cell biology, Cancer research, Virology, Genetics, Virus, GeneTop concepts (fields/topics) attached by OpenAlex
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8Total citation count in OpenAlex
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2025: 3, 2024: 5Per-year citation counts (last 5 years)
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162Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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