Microsurgical Management of Complex Hypothalamic Hamartomas in the Era of Minimally Invasive Therapy: A Case Series and Narrative Review Article Swipe
Kurt Lehner
,
Randy S. D’Amico
,
Ralph Rahme
,
Júlia Schneider
,
Gloria G. Privler
,
Lukas J. Faltings
,
Victor Du
,
John A. Boockvar
,
Harold L. Rekate
,
David J. Langer
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-947196/v1
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-947196/v1
IntroductionRecently, there has been a paradigm shift in the management of hypothalamic hamartoma (HH) from traditional microsurgical techniques to less invasive alternatives such as stereotactic radiosurgery and laser interstitial thermal therapy. However, large and extensive HH may fail to respond to minimally invasive therapies, ultimately necessitating microsurgery.MethodsAll patients who underwent microsurgical resection of a complex HH by the 2 senior authors (D.J.L., H.L.R.) in 2011-2017 were included. Charts were retrospectively reviewed and demographic, clinical, imaging, and outcome data were recorded.Results8 patients, 7 children and 1 adult, with a mean age of 7 years (10 months-27 years), were included. Of those, 2 had failed previous treatments. All 7 children presented with pharmacoresistant gelastic seizures and cognitive dysfunction, 6 exhibited central precocious puberty, and 3 had behavioral problems. Other seizure types affected 6/8 patients. Mean lesion size was 21.6 mm (14-31), all with interpeduncular extension and 5 with intraventricular extension (Delalande type I: 3, type III: 4, type IV: 1). A frontotemporal orbitozygomatic (FTOZ) approach with optic nerve decompression was used in all patients, supplemented by another approach in 3 (endoscopic transventricular: 3, transcallosal: 1). Gross total resection was achieved in 6 patients and subtotal resection in 2. Transient complications occurred in 3 patients (37.5%): self-limited sodium imbalance (n=3), subdural hygroma (n=2). Permanent complications occurred in 2 patients (25%): perforator infarct (n=1), short-term memory loss (n=1). All patients experienced seizure resolution postoperatively with preserved hypothalamic-pituitary axis function. After a mean follow-up of 41 months (2-66), 7 patients remain seizure-free, while 1 has rare recurrent seizures. Cognitive and behavioral symptoms improved significantly in all patients.ConclusionFor large HH with interpeduncular extension, microsurgery via the FTOZ approach is a safe and highly effective treatment modality.
Related Topics
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.21203/rs.3.rs-947196/v1
- https://www.researchsquare.com/article/rs-947196/latest.pdf
- OA Status
- gold
- Cited By
- 1
- References
- 39
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3211507035
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3211507035Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.21203/rs.3.rs-947196/v1Digital Object Identifier
- Title
-
Microsurgical Management of Complex Hypothalamic Hamartomas in the Era of Minimally Invasive Therapy: A Case Series and Narrative ReviewWork title
- Type
-
preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-10-20Full publication date if available
- Authors
-
Kurt Lehner, Randy S. D’Amico, Ralph Rahme, Júlia Schneider, Gloria G. Privler, Lukas J. Faltings, Victor Du, John A. Boockvar, Harold L. Rekate, David J. LangerList of authors in order
- Landing page
-
https://doi.org/10.21203/rs.3.rs-947196/v1Publisher landing page
- PDF URL
-
https://www.researchsquare.com/article/rs-947196/latest.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.researchsquare.com/article/rs-947196/latest.pdfDirect OA link when available
- Concepts
-
Narrative, Series (stratigraphy), History, Medicine, Art, Literature, Paleontology, BiologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
1Total citation count in OpenAlex
- Citations by year (recent)
-
2023: 1Per-year citation counts (last 5 years)
- References (count)
-
39Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W3211507035 |
|---|---|
| doi | https://doi.org/10.21203/rs.3.rs-947196/v1 |
| ids.doi | https://doi.org/10.21203/rs.3.rs-947196/v1 |
| ids.mag | 3211507035 |
| ids.openalex | https://openalex.org/W3211507035 |
| fwci | 0.19428122 |
| type | preprint |
| title | Microsurgical Management of Complex Hypothalamic Hamartomas in the Era of Minimally Invasive Therapy: A Case Series and Narrative Review |
| biblio.issue | |
| biblio.volume | |
| biblio.last_page | |
| biblio.first_page | |
| topics[0].id | https://openalex.org/T10094 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 0.9991000294685364 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2738 |
| topics[0].subfield.display_name | Psychiatry and Mental health |
| topics[0].display_name | Epilepsy research and treatment |
| topics[1].id | https://openalex.org/T12229 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.9990000128746033 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2735 |
| topics[1].subfield.display_name | Pediatrics, Perinatology and Child Health |
| topics[1].display_name | Pharmacological Effects and Toxicity Studies |
| topics[2].id | https://openalex.org/T10832 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.995199978351593 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2712 |
| topics[2].subfield.display_name | Endocrinology, Diabetes and Metabolism |
| topics[2].display_name | Pituitary Gland Disorders and Treatments |
| is_xpac | False |
| apc_list | |
| apc_paid | |
| concepts[0].id | https://openalex.org/C199033989 |
| concepts[0].level | 2 |
| concepts[0].score | 0.7217186689376831 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q1318295 |
| concepts[0].display_name | Narrative |
| concepts[1].id | https://openalex.org/C143724316 |
| concepts[1].level | 2 |
| concepts[1].score | 0.4357556700706482 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q312468 |
| concepts[1].display_name | Series (stratigraphy) |
| concepts[2].id | https://openalex.org/C95457728 |
| concepts[2].level | 0 |
| concepts[2].score | 0.34805458784103394 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q309 |
| concepts[2].display_name | History |
| concepts[3].id | https://openalex.org/C71924100 |
| concepts[3].level | 0 |
| concepts[3].score | 0.34249550104141235 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[3].display_name | Medicine |
| concepts[4].id | https://openalex.org/C142362112 |
| concepts[4].level | 0 |
| concepts[4].score | 0.3206847906112671 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q735 |
| concepts[4].display_name | Art |
| concepts[5].id | https://openalex.org/C124952713 |
| concepts[5].level | 1 |
| concepts[5].score | 0.26250991225242615 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q8242 |
| concepts[5].display_name | Literature |
| concepts[6].id | https://openalex.org/C151730666 |
| concepts[6].level | 1 |
| concepts[6].score | 0.1096494197845459 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q7205 |
| concepts[6].display_name | Paleontology |
| concepts[7].id | https://openalex.org/C86803240 |
| concepts[7].level | 0 |
| concepts[7].score | 0.10202232003211975 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[7].display_name | Biology |
| keywords[0].id | https://openalex.org/keywords/narrative |
| keywords[0].score | 0.7217186689376831 |
| keywords[0].display_name | Narrative |
| keywords[1].id | https://openalex.org/keywords/series |
| keywords[1].score | 0.4357556700706482 |
| keywords[1].display_name | Series (stratigraphy) |
| keywords[2].id | https://openalex.org/keywords/history |
| keywords[2].score | 0.34805458784103394 |
| keywords[2].display_name | History |
| keywords[3].id | https://openalex.org/keywords/medicine |
| keywords[3].score | 0.34249550104141235 |
| keywords[3].display_name | Medicine |
| keywords[4].id | https://openalex.org/keywords/art |
| keywords[4].score | 0.3206847906112671 |
| keywords[4].display_name | Art |
| keywords[5].id | https://openalex.org/keywords/literature |
| keywords[5].score | 0.26250991225242615 |
| keywords[5].display_name | Literature |
| keywords[6].id | https://openalex.org/keywords/paleontology |
| keywords[6].score | 0.1096494197845459 |
| keywords[6].display_name | Paleontology |
| keywords[7].id | https://openalex.org/keywords/biology |
| keywords[7].score | 0.10202232003211975 |
| keywords[7].display_name | Biology |
| language | en |
| locations[0].id | doi:10.21203/rs.3.rs-947196/v1 |
| locations[0].is_oa | True |
| locations[0].source | |
| locations[0].license | cc-by |
| locations[0].pdf_url | https://www.researchsquare.com/article/rs-947196/latest.pdf |
| locations[0].version | acceptedVersion |
| locations[0].raw_type | posted-content |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | False |
| locations[0].raw_source_name | |
| locations[0].landing_page_url | https://doi.org/10.21203/rs.3.rs-947196/v1 |
| indexed_in | crossref |
| authorships[0].author.id | https://openalex.org/A5079016716 |
| authorships[0].author.orcid | https://orcid.org/0000-0001-7916-1357 |
| authorships[0].author.display_name | Kurt Lehner |
| authorships[0].countries | US |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I145311948, https://openalex.org/I2799853436, https://openalex.org/I4210150714 |
| authorships[0].affiliations[0].raw_affiliation_string | Johns Hopkins Hospital: Johns Hopkins Medicine |
| authorships[0].institutions[0].id | https://openalex.org/I4210150714 |
| authorships[0].institutions[0].ror | https://ror.org/05cb1k848 |
| authorships[0].institutions[0].type | healthcare |
| authorships[0].institutions[0].lineage | https://openalex.org/I2799853436, https://openalex.org/I4210150714 |
| authorships[0].institutions[0].country_code | US |
| authorships[0].institutions[0].display_name | Johns Hopkins Hospital |
| authorships[0].institutions[1].id | https://openalex.org/I2799853436 |
| authorships[0].institutions[1].ror | https://ror.org/037zgn354 |
| authorships[0].institutions[1].type | healthcare |
| authorships[0].institutions[1].lineage | https://openalex.org/I2799853436 |
| authorships[0].institutions[1].country_code | US |
| authorships[0].institutions[1].display_name | Johns Hopkins Medicine |
| authorships[0].institutions[2].id | https://openalex.org/I145311948 |
| authorships[0].institutions[2].ror | https://ror.org/00za53h95 |
| authorships[0].institutions[2].type | education |
| authorships[0].institutions[2].lineage | https://openalex.org/I145311948 |
| authorships[0].institutions[2].country_code | US |
| authorships[0].institutions[2].display_name | Johns Hopkins University |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Kurt R Lehner |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Johns Hopkins Hospital: Johns Hopkins Medicine |
| authorships[1].author.id | https://openalex.org/A5078517937 |
| authorships[1].author.orcid | https://orcid.org/0000-0002-3047-945X |
| authorships[1].author.display_name | Randy S. D’Amico |
| authorships[1].countries | US |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I2800628709 |
| authorships[1].affiliations[0].raw_affiliation_string | Lenox Hill Hospital |
| authorships[1].institutions[0].id | https://openalex.org/I2800628709 |
| authorships[1].institutions[0].ror | https://ror.org/0231d2y50 |
| authorships[1].institutions[0].type | healthcare |
| authorships[1].institutions[0].lineage | https://openalex.org/I1302444339, https://openalex.org/I2800628709 |
| authorships[1].institutions[0].country_code | US |
| authorships[1].institutions[0].display_name | Lenox Hill Hospital |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Randy S. D'Amico |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Lenox Hill Hospital |
| authorships[2].author.id | https://openalex.org/A5045391399 |
| authorships[2].author.orcid | https://orcid.org/0000-0003-1796-7296 |
| authorships[2].author.display_name | Ralph Rahme |
| authorships[2].countries | US |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I1302444339 |
| authorships[2].affiliations[0].raw_affiliation_string | Northwell Health |
| authorships[2].institutions[0].id | https://openalex.org/I1302444339 |
| authorships[2].institutions[0].ror | https://ror.org/02bxt4m23 |
| authorships[2].institutions[0].type | healthcare |
| authorships[2].institutions[0].lineage | https://openalex.org/I1302444339 |
| authorships[2].institutions[0].country_code | US |
| authorships[2].institutions[0].display_name | Northwell Health |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Ralph Rahme |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Northwell Health |
| authorships[3].author.id | https://openalex.org/A5101788782 |
| authorships[3].author.orcid | https://orcid.org/0000-0003-3100-551X |
| authorships[3].author.display_name | Júlia Schneider |
| authorships[3].countries | US |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I2800628709 |
| authorships[3].affiliations[0].raw_affiliation_string | Lenox Hill Hospital |
| authorships[3].institutions[0].id | https://openalex.org/I2800628709 |
| authorships[3].institutions[0].ror | https://ror.org/0231d2y50 |
| authorships[3].institutions[0].type | healthcare |
| authorships[3].institutions[0].lineage | https://openalex.org/I1302444339, https://openalex.org/I2800628709 |
| authorships[3].institutions[0].country_code | US |
| authorships[3].institutions[0].display_name | Lenox Hill Hospital |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Julia R. Schneider |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Lenox Hill Hospital |
| authorships[4].author.id | https://openalex.org/A5027373784 |
| authorships[4].author.orcid | |
| authorships[4].author.display_name | Gloria G. Privler |
| authorships[4].countries | US |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I2800628709 |
| authorships[4].affiliations[0].raw_affiliation_string | Lenox Hill Hospital |
| authorships[4].institutions[0].id | https://openalex.org/I2800628709 |
| authorships[4].institutions[0].ror | https://ror.org/0231d2y50 |
| authorships[4].institutions[0].type | healthcare |
| authorships[4].institutions[0].lineage | https://openalex.org/I1302444339, https://openalex.org/I2800628709 |
| authorships[4].institutions[0].country_code | US |
| authorships[4].institutions[0].display_name | Lenox Hill Hospital |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Gloria G. Privler |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Lenox Hill Hospital |
| authorships[5].author.id | https://openalex.org/A5081245833 |
| authorships[5].author.orcid | |
| authorships[5].author.display_name | Lukas J. Faltings |
| authorships[5].countries | US |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I2800628709 |
| authorships[5].affiliations[0].raw_affiliation_string | Lenox Hill Hospital |
| authorships[5].institutions[0].id | https://openalex.org/I2800628709 |
| authorships[5].institutions[0].ror | https://ror.org/0231d2y50 |
| authorships[5].institutions[0].type | healthcare |
| authorships[5].institutions[0].lineage | https://openalex.org/I1302444339, https://openalex.org/I2800628709 |
| authorships[5].institutions[0].country_code | US |
| authorships[5].institutions[0].display_name | Lenox Hill Hospital |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Lukas J. Faltings |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Lenox Hill Hospital |
| authorships[6].author.id | https://openalex.org/A5035873011 |
| authorships[6].author.orcid | |
| authorships[6].author.display_name | Victor Du |
| authorships[6].countries | US |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I1302444339 |
| authorships[6].affiliations[0].raw_affiliation_string | Northwell Health |
| authorships[6].institutions[0].id | https://openalex.org/I1302444339 |
| authorships[6].institutions[0].ror | https://ror.org/02bxt4m23 |
| authorships[6].institutions[0].type | healthcare |
| authorships[6].institutions[0].lineage | https://openalex.org/I1302444339 |
| authorships[6].institutions[0].country_code | US |
| authorships[6].institutions[0].display_name | Northwell Health |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Victor X. Du |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Northwell Health |
| authorships[7].author.id | https://openalex.org/A5048782315 |
| authorships[7].author.orcid | https://orcid.org/0000-0002-8137-6303 |
| authorships[7].author.display_name | John A. Boockvar |
| authorships[7].countries | US |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I2800628709 |
| authorships[7].affiliations[0].raw_affiliation_string | Lenox Hill Hospital |
| authorships[7].institutions[0].id | https://openalex.org/I2800628709 |
| authorships[7].institutions[0].ror | https://ror.org/0231d2y50 |
| authorships[7].institutions[0].type | healthcare |
| authorships[7].institutions[0].lineage | https://openalex.org/I1302444339, https://openalex.org/I2800628709 |
| authorships[7].institutions[0].country_code | US |
| authorships[7].institutions[0].display_name | Lenox Hill Hospital |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | John A. Boockvar |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Lenox Hill Hospital |
| authorships[8].author.id | https://openalex.org/A5082807126 |
| authorships[8].author.orcid | https://orcid.org/0000-0001-6080-9803 |
| authorships[8].author.display_name | Harold L. Rekate |
| authorships[8].countries | US |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I1302444339 |
| authorships[8].affiliations[0].raw_affiliation_string | Northwell Health |
| authorships[8].institutions[0].id | https://openalex.org/I1302444339 |
| authorships[8].institutions[0].ror | https://ror.org/02bxt4m23 |
| authorships[8].institutions[0].type | healthcare |
| authorships[8].institutions[0].lineage | https://openalex.org/I1302444339 |
| authorships[8].institutions[0].country_code | US |
| authorships[8].institutions[0].display_name | Northwell Health |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Harold L. Rekate |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Northwell Health |
| authorships[9].author.id | https://openalex.org/A5070923679 |
| authorships[9].author.orcid | https://orcid.org/0000-0001-6028-2765 |
| authorships[9].author.display_name | David J. Langer |
| authorships[9].countries | US |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I2800628709 |
| authorships[9].affiliations[0].raw_affiliation_string | Lenox Hill Hospital |
| authorships[9].institutions[0].id | https://openalex.org/I2800628709 |
| authorships[9].institutions[0].ror | https://ror.org/0231d2y50 |
| authorships[9].institutions[0].type | healthcare |
| authorships[9].institutions[0].lineage | https://openalex.org/I1302444339, https://openalex.org/I2800628709 |
| authorships[9].institutions[0].country_code | US |
| authorships[9].institutions[0].display_name | Lenox Hill Hospital |
| authorships[9].author_position | last |
| authorships[9].raw_author_name | David J. Langer |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | Lenox Hill Hospital |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.researchsquare.com/article/rs-947196/latest.pdf |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Microsurgical Management of Complex Hypothalamic Hamartomas in the Era of Minimally Invasive Therapy: A Case Series and Narrative Review |
| has_fulltext | True |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10094 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 0.9991000294685364 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2738 |
| primary_topic.subfield.display_name | Psychiatry and Mental health |
| primary_topic.display_name | Epilepsy research and treatment |
| related_works | https://openalex.org/W4387497383, https://openalex.org/W3183948672, https://openalex.org/W3173606202, https://openalex.org/W3110381201, https://openalex.org/W2948807893, https://openalex.org/W2899084033, https://openalex.org/W2778153218, https://openalex.org/W2758277628, https://openalex.org/W2748952813, https://openalex.org/W1531601525 |
| cited_by_count | 1 |
| counts_by_year[0].year | 2023 |
| counts_by_year[0].cited_by_count | 1 |
| locations_count | 1 |
| best_oa_location.id | doi:10.21203/rs.3.rs-947196/v1 |
| best_oa_location.is_oa | True |
| best_oa_location.source | |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | https://www.researchsquare.com/article/rs-947196/latest.pdf |
| best_oa_location.version | acceptedVersion |
| best_oa_location.raw_type | posted-content |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | False |
| best_oa_location.raw_source_name | |
| best_oa_location.landing_page_url | https://doi.org/10.21203/rs.3.rs-947196/v1 |
| primary_location.id | doi:10.21203/rs.3.rs-947196/v1 |
| primary_location.is_oa | True |
| primary_location.source | |
| primary_location.license | cc-by |
| primary_location.pdf_url | https://www.researchsquare.com/article/rs-947196/latest.pdf |
| primary_location.version | acceptedVersion |
| primary_location.raw_type | posted-content |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | False |
| primary_location.raw_source_name | |
| primary_location.landing_page_url | https://doi.org/10.21203/rs.3.rs-947196/v1 |
| publication_date | 2021-10-20 |
| publication_year | 2021 |
| referenced_works | https://openalex.org/W2144418257, https://openalex.org/W2052569134, https://openalex.org/W4245113705, https://openalex.org/W2094474685, https://openalex.org/W2051523366, https://openalex.org/W1995470959, https://openalex.org/W2047414905, https://openalex.org/W2083850064, https://openalex.org/W2087095134, https://openalex.org/W1967999150, https://openalex.org/W1969925610, https://openalex.org/W2058363675, https://openalex.org/W1745218475, https://openalex.org/W1548380418, https://openalex.org/W2063185652, https://openalex.org/W1990840531, https://openalex.org/W2216182014, https://openalex.org/W1826370134, https://openalex.org/W2078417984, https://openalex.org/W4254946787, https://openalex.org/W2409883442, https://openalex.org/W1980559718, https://openalex.org/W2341901612, https://openalex.org/W2063868884, https://openalex.org/W1997815981, https://openalex.org/W1990834358, https://openalex.org/W2094280244, https://openalex.org/W4240252424, https://openalex.org/W4235993237, https://openalex.org/W2023707466, https://openalex.org/W1965881853, https://openalex.org/W1502099237, https://openalex.org/W2755913148, https://openalex.org/W2783470766, https://openalex.org/W2587652377, https://openalex.org/W1936684665, https://openalex.org/W1737808969, https://openalex.org/W1108032874, https://openalex.org/W2106642224 |
| referenced_works_count | 39 |
| abstract_inverted_index.1 | 85, 249 |
| abstract_inverted_index.2 | 59, 101, 215 |
| abstract_inverted_index.3 | 123, 178, 201 |
| abstract_inverted_index.5 | 145 |
| abstract_inverted_index.6 | 117, 190 |
| abstract_inverted_index.7 | 82, 92, 107, 244 |
| abstract_inverted_index.A | 159 |
| abstract_inverted_index.a | 5, 54, 88, 237, 274 |
| abstract_inverted_index.2. | 196 |
| abstract_inverted_index.3, | 152, 181 |
| abstract_inverted_index.4, | 155 |
| abstract_inverted_index.41 | 241 |
| abstract_inverted_index.HH | 36, 56, 264 |
| abstract_inverted_index.I: | 151 |
| abstract_inverted_index.Of | 99 |
| abstract_inverted_index.as | 24 |
| abstract_inverted_index.by | 57, 174 |
| abstract_inverted_index.in | 8, 64, 170, 177, 189, 195, 200, 214, 260 |
| abstract_inverted_index.is | 273 |
| abstract_inverted_index.mm | 138 |
| abstract_inverted_index.of | 11, 53, 91, 240 |
| abstract_inverted_index.to | 19, 39, 41 |
| abstract_inverted_index.(10 | 94 |
| abstract_inverted_index.1). | 158, 183 |
| abstract_inverted_index.6/8 | 131 |
| abstract_inverted_index.All | 106, 225 |
| abstract_inverted_index.IV: | 157 |
| abstract_inverted_index.age | 90 |
| abstract_inverted_index.all | 140, 171, 261 |
| abstract_inverted_index.and | 27, 34, 72, 76, 84, 114, 122, 144, 192, 255, 276 |
| abstract_inverted_index.had | 102, 124 |
| abstract_inverted_index.has | 3, 250 |
| abstract_inverted_index.may | 37 |
| abstract_inverted_index.the | 9, 58, 270 |
| abstract_inverted_index.via | 269 |
| abstract_inverted_index.was | 136, 168, 187 |
| abstract_inverted_index.who | 49 |
| abstract_inverted_index.(HH) | 14 |
| abstract_inverted_index.21.6 | 137 |
| abstract_inverted_index.FTOZ | 271 |
| abstract_inverted_index.III: | 154 |
| abstract_inverted_index.Mean | 133 |
| abstract_inverted_index.axis | 234 |
| abstract_inverted_index.been | 4 |
| abstract_inverted_index.data | 78 |
| abstract_inverted_index.fail | 38 |
| abstract_inverted_index.from | 15 |
| abstract_inverted_index.less | 20 |
| abstract_inverted_index.loss | 223 |
| abstract_inverted_index.mean | 89, 238 |
| abstract_inverted_index.rare | 251 |
| abstract_inverted_index.safe | 275 |
| abstract_inverted_index.size | 135 |
| abstract_inverted_index.such | 23 |
| abstract_inverted_index.type | 150, 153, 156 |
| abstract_inverted_index.used | 169 |
| abstract_inverted_index.were | 66, 69, 79, 97 |
| abstract_inverted_index.with | 87, 110, 141, 146, 164, 231, 265 |
| abstract_inverted_index.After | 236 |
| abstract_inverted_index.Gross | 184 |
| abstract_inverted_index.Other | 127 |
| abstract_inverted_index.large | 33, 263 |
| abstract_inverted_index.laser | 28 |
| abstract_inverted_index.nerve | 166 |
| abstract_inverted_index.optic | 165 |
| abstract_inverted_index.shift | 7 |
| abstract_inverted_index.there | 2 |
| abstract_inverted_index.total | 185 |
| abstract_inverted_index.types | 129 |
| abstract_inverted_index.while | 248 |
| abstract_inverted_index.years | 93 |
| abstract_inverted_index.(25%): | 217 |
| abstract_inverted_index.(FTOZ) | 162 |
| abstract_inverted_index.(n=1), | 220 |
| abstract_inverted_index.(n=1). | 224 |
| abstract_inverted_index.(n=2). | 210 |
| abstract_inverted_index.(n=3), | 207 |
| abstract_inverted_index.Charts | 68 |
| abstract_inverted_index.adult, | 86 |
| abstract_inverted_index.failed | 103 |
| abstract_inverted_index.highly | 277 |
| abstract_inverted_index.lesion | 134 |
| abstract_inverted_index.memory | 222 |
| abstract_inverted_index.months | 242 |
| abstract_inverted_index.remain | 246 |
| abstract_inverted_index.senior | 60 |
| abstract_inverted_index.sodium | 205 |
| abstract_inverted_index.those, | 100 |
| abstract_inverted_index.(2-66), | 243 |
| abstract_inverted_index.H.L.R.) | 63 |
| abstract_inverted_index.another | 175 |
| abstract_inverted_index.authors | 61 |
| abstract_inverted_index.central | 119 |
| abstract_inverted_index.complex | 55 |
| abstract_inverted_index.hygroma | 209 |
| abstract_inverted_index.infarct | 219 |
| abstract_inverted_index.outcome | 77 |
| abstract_inverted_index.respond | 40 |
| abstract_inverted_index.seizure | 128, 228 |
| abstract_inverted_index.thermal | 30 |
| abstract_inverted_index.years), | 96 |
| abstract_inverted_index.(14-31), | 139 |
| abstract_inverted_index.(37.5%): | 203 |
| abstract_inverted_index.(D.J.L., | 62 |
| abstract_inverted_index.However, | 32 |
| abstract_inverted_index.achieved | 188 |
| abstract_inverted_index.affected | 130 |
| abstract_inverted_index.approach | 163, 176, 272 |
| abstract_inverted_index.children | 83, 108 |
| abstract_inverted_index.gelastic | 112 |
| abstract_inverted_index.imaging, | 75 |
| abstract_inverted_index.improved | 258 |
| abstract_inverted_index.invasive | 21, 43 |
| abstract_inverted_index.occurred | 199, 213 |
| abstract_inverted_index.paradigm | 6 |
| abstract_inverted_index.patients | 48, 191, 202, 216, 226, 245 |
| abstract_inverted_index.previous | 104 |
| abstract_inverted_index.puberty, | 121 |
| abstract_inverted_index.reviewed | 71 |
| abstract_inverted_index.seizures | 113 |
| abstract_inverted_index.subdural | 208 |
| abstract_inverted_index.subtotal | 193 |
| abstract_inverted_index.symptoms | 257 |
| abstract_inverted_index.therapy. | 31 |
| abstract_inverted_index.2011-2017 | 65 |
| abstract_inverted_index.Cognitive | 254 |
| abstract_inverted_index.Permanent | 211 |
| abstract_inverted_index.Transient | 197 |
| abstract_inverted_index.clinical, | 74 |
| abstract_inverted_index.cognitive | 115 |
| abstract_inverted_index.effective | 278 |
| abstract_inverted_index.exhibited | 118 |
| abstract_inverted_index.extension | 143, 148 |
| abstract_inverted_index.extensive | 35 |
| abstract_inverted_index.follow-up | 239 |
| abstract_inverted_index.function. | 235 |
| abstract_inverted_index.hamartoma | 13 |
| abstract_inverted_index.imbalance | 206 |
| abstract_inverted_index.included. | 67, 98 |
| abstract_inverted_index.minimally | 42 |
| abstract_inverted_index.modality. | 280 |
| abstract_inverted_index.months-27 | 95 |
| abstract_inverted_index.patients, | 81, 172 |
| abstract_inverted_index.patients. | 132 |
| abstract_inverted_index.presented | 109 |
| abstract_inverted_index.preserved | 232 |
| abstract_inverted_index.problems. | 126 |
| abstract_inverted_index.recurrent | 252 |
| abstract_inverted_index.resection | 52, 186, 194 |
| abstract_inverted_index.seizures. | 253 |
| abstract_inverted_index.treatment | 279 |
| abstract_inverted_index.underwent | 50 |
| abstract_inverted_index.(Delalande | 149 |
| abstract_inverted_index.behavioral | 125, 256 |
| abstract_inverted_index.extension, | 267 |
| abstract_inverted_index.management | 10 |
| abstract_inverted_index.perforator | 218 |
| abstract_inverted_index.precocious | 120 |
| abstract_inverted_index.resolution | 229 |
| abstract_inverted_index.short-term | 221 |
| abstract_inverted_index.techniques | 18 |
| abstract_inverted_index.therapies, | 44 |
| abstract_inverted_index.ultimately | 45 |
| abstract_inverted_index.(endoscopic | 179 |
| abstract_inverted_index.experienced | 227 |
| abstract_inverted_index.traditional | 16 |
| abstract_inverted_index.treatments. | 105 |
| abstract_inverted_index.alternatives | 22 |
| abstract_inverted_index.demographic, | 73 |
| abstract_inverted_index.dysfunction, | 116 |
| abstract_inverted_index.hypothalamic | 12 |
| abstract_inverted_index.interstitial | 29 |
| abstract_inverted_index.microsurgery | 268 |
| abstract_inverted_index.radiosurgery | 26 |
| abstract_inverted_index.self-limited | 204 |
| abstract_inverted_index.stereotactic | 25 |
| abstract_inverted_index.supplemented | 173 |
| abstract_inverted_index.complications | 198, 212 |
| abstract_inverted_index.decompression | 167 |
| abstract_inverted_index.microsurgical | 17, 51 |
| abstract_inverted_index.necessitating | 46 |
| abstract_inverted_index.seizure-free, | 247 |
| abstract_inverted_index.significantly | 259 |
| abstract_inverted_index.frontotemporal | 160 |
| abstract_inverted_index.transcallosal: | 182 |
| abstract_inverted_index.interpeduncular | 142, 266 |
| abstract_inverted_index.orbitozygomatic | 161 |
| abstract_inverted_index.postoperatively | 230 |
| abstract_inverted_index.retrospectively | 70 |
| abstract_inverted_index.intraventricular | 147 |
| abstract_inverted_index.pharmacoresistant | 111 |
| abstract_inverted_index.recorded.Results8 | 80 |
| abstract_inverted_index.transventricular: | 180 |
| abstract_inverted_index.IntroductionRecently, | 1 |
| abstract_inverted_index.hypothalamic-pituitary | 233 |
| abstract_inverted_index.<title>Abstract</title> | 0 |
| abstract_inverted_index.microsurgery.MethodsAll | 47 |
| abstract_inverted_index.patients.ConclusionFor | 262 |
| cited_by_percentile_year.max | 94 |
| cited_by_percentile_year.min | 89 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 10 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.6700000166893005 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.50319671 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |