Microvascular cerebral blood flow response to intrathecal nicardipine is associated with delayed cerebral ischemia Article Swipe
Eashani Sathialingam
,
Kyle R. Cowdrick
,
Amanda Liew
,
Zhou Fang
,
Seung Yup Lee
,
Courtney McCracken
,
Feras Akbik
,
Owen Samuels
,
Prem Kandiah
,
Ofer Sadan
,
Erin M. Buckley
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3389/fneur.2023.1052232
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3389/fneur.2023.1052232
One of the common complications of non-traumatic subarachnoid hemorrhage (SAH) is delayed cerebral ischemia (DCI). Intrathecal (IT) administration of nicardipine, a calcium channel blocker (CCB), upon detection of large-artery cerebral vasospasm holds promise as a treatment that reduces the incidence of DCI. In this observational study, we prospectively employed a non-invasive optical modality called diffuse correlation spectroscopy (DCS) to quantify the acute microvascular cerebral blood flow (CBF) response to IT nicardipine (up to 90 min) in 20 patients with medium-high grade non-traumatic SAH. On average, CBF increased significantly with time post-administration. However, the CBF response was heterogeneous across subjects. A latent class mixture model was able to classify 19 out of 20 patients into two distinct classes of CBF response: patients in Class 1 ( n = 6) showed no significant change in CBF, while patients in Class 2 ( n = 13) showed a pronounced increase in CBF in response to nicardipine. The incidence of DCI was 5 out of 6 in Class 1 and 1 out of 13 in Class 2 ( p < 0.001). These results suggest that the acute (<90 min) DCS-measured CBF response to IT nicardipine is associated with intermediate-term (up to 3 weeks) development of DCI.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fneur.2023.1052232
- OA Status
- gold
- Cited By
- 11
- References
- 48
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4327699244
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4327699244Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3389/fneur.2023.1052232Digital Object Identifier
- Title
-
Microvascular cerebral blood flow response to intrathecal nicardipine is associated with delayed cerebral ischemiaWork title
- Type
-
articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-03-17Full publication date if available
- Authors
-
Eashani Sathialingam, Kyle R. Cowdrick, Amanda Liew, Zhou Fang, Seung Yup Lee, Courtney McCracken, Feras Akbik, Owen Samuels, Prem Kandiah, Ofer Sadan, Erin M. BuckleyList of authors in order
- Landing page
-
https://doi.org/10.3389/fneur.2023.1052232Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.3389/fneur.2023.1052232Direct OA link when available
- Concepts
-
Nicardipine, Cerebral blood flow, Medicine, Ischemia, Anesthesia, Intrathecal, Cerebral circulation, Cardiology, Internal medicine, Blood pressureTop concepts (fields/topics) attached by OpenAlex
- Cited by
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11Total citation count in OpenAlex
- Citations by year (recent)
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2025: 1, 2024: 6, 2023: 4Per-year citation counts (last 5 years)
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48Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| cited_by_percentile_year.min | 91 |
| corresponding_author_ids | https://openalex.org/A5091312187 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 11 |
| corresponding_institution_ids | https://openalex.org/I130701444, https://openalex.org/I150468666, https://openalex.org/I2802612298, https://openalex.org/I4210146983 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.8399999737739563 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.90130005 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |