Mild Behavioral Impairment Is Associated With Atrophy of Entorhinal Cortex and Hippocampus in a Memory Clinic Cohort Article Swipe
Veronika Matušková
,
Zahinoor Ismail
,
Tomáš Nikolai
,
Hana Marková
,
Kateřina Čechová
,
Zuzana Nedelská
,
Jan Laczó
,
Meng Wang
,
Jakub Hort
,
Martin Vyhnálek
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3389/fnagi.2021.643271
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3389/fnagi.2021.643271
Objectives Mild behavioral impairment (MBI) is a syndrome describing late-onset persistent neuropsychiatric symptoms (NPS) in non-demented older adults. Few studies to date have investigated the associations of MBI with structural brain changes. Our aim was to explore structural correlates of NPS in a non-demented memory clinic sample using the Mild Behavioral Impairment Checklist (MBI-C) that has been developed to measure MBI. Methods One hundred sixteen non-demented older adults from the Czech Brain Aging Study with subjective cognitive concerns were classified as subjective cognitive decline ( n = 37) or mild cognitive impairment ( n = 79). Participants underwent neurological and neuropsychological examinations and brain magnetic resonance imaging (MRI) (1.5 T). The Czech version of the MBI-C was administered to participants’ informants. Five a priori selected brain regions were measured, namely, thicknesses of the orbitofrontal cortex (OFC), anterior cingulate cortex (ACC), posterior cingulate cortex (PCC), and entorhinal cortex (ERC) and volume of the hippocampus (HV), and correlated with MBI-C total and domain scores. Results Entorhinal cortex was associated with MBI-C total score ( r S = −0.368, p < 0.001) and with impulse dyscontrol score ( r S = −0.284, p = 0.002). HV was associated with decreased motivation ( r S = −0.248, p = 0.008) and impulse dyscontrol score ( r S = −0.240, p = 0.011). Conclusion Neuropsychiatric symptoms, particularly in the MBI impulse dyscontrol and motivation domains, are associated with medial temporal lobe atrophy in a clinical cohort of non-demented older adults. This study supports earlier involvement of temporal rather than frontal regions in NPS manifestation. Since these regions are typically affected early in the course of Alzheimer’s disease (AD), the MBI-C may potentially help further identify individuals at-risk of developing AD dementia.
Related Topics
Concepts
Entorhinal cortex
Atrophy
Psychology
Cohort
Anterior cingulate cortex
Hippocampus
Cingulate cortex
Orbitofrontal cortex
Neuropsychology
Temporal cortex
Dementia
Posterior cingulate
Temporal lobe
Memory clinic
Audiology
Medicine
Neuroscience
Cortex (anatomy)
Cognition
Internal medicine
Cognitive impairment
Prefrontal cortex
Epilepsy
Central nervous system
Disease
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fnagi.2021.643271
- OA Status
- gold
- Cited By
- 105
- References
- 78
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3164873503
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3164873503Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3389/fnagi.2021.643271Digital Object Identifier
- Title
-
Mild Behavioral Impairment Is Associated With Atrophy of Entorhinal Cortex and Hippocampus in a Memory Clinic CohortWork title
- Type
-
articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2021Year of publication
- Publication date
-
2021-05-24Full publication date if available
- Authors
-
Veronika Matušková, Zahinoor Ismail, Tomáš Nikolai, Hana Marková, Kateřina Čechová, Zuzana Nedelská, Jan Laczó, Meng Wang, Jakub Hort, Martin VyhnálekList of authors in order
- Landing page
-
https://doi.org/10.3389/fnagi.2021.643271Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.3389/fnagi.2021.643271Direct OA link when available
- Concepts
-
Entorhinal cortex, Atrophy, Psychology, Cohort, Anterior cingulate cortex, Hippocampus, Cingulate cortex, Orbitofrontal cortex, Neuropsychology, Temporal cortex, Dementia, Posterior cingulate, Temporal lobe, Memory clinic, Audiology, Medicine, Neuroscience, Cortex (anatomy), Cognition, Internal medicine, Cognitive impairment, Prefrontal cortex, Epilepsy, Central nervous system, DiseaseTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
105Total citation count in OpenAlex
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2025: 20, 2024: 22, 2023: 34, 2022: 19, 2021: 8Per-year citation counts (last 5 years)
- References (count)
-
78Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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