Minimal Reconstitution of Membranous Web Induced by a Vesicle–Peptide Sol–Gel Transition Article Swipe
James C. S. Ho
,
Christoph Steininger
,
Shu Hui Hiew
,
Min Chul Kim
,
Erik Reimhult
,
Ali Miserez
,
Nam‐Joon Cho
,
Atul N. Parikh
,
Bo Liedberg
·
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.1021/acs.biomac.9b00081
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.1021/acs.biomac.9b00081
Positive strand RNA viruses replicate in specialized niches called membranous web within the cytoplasm of host cells. These virus replication organelles sequester viral proteins, RNA, and a variety of host factors within a fluid, amorphous matrix of clusters of endoplasmic reticulum (ER) derived vesicles. They are thought to form by the actions of a nonstructural viral protein NS4B, which remodels the ER and produces dense lipid-protein condensates. Here, we used in vitro reconstitution to identify the minimal components and elucidate physical mechanisms driving the web formation. We found that the N-terminal amphipathic domain of NS4B (peptide 4BAH2) and phospholipid vesicles (∼100-200 nm in diameter) were sufficient to produce a gel-like, viscoelastic condensate. This condensate coexists with the surrounding aqueous phase and affords rapid exchange of molecules. Together, it recapitulates the essential properties of the virus-induced membranous web. Our data support a novel phase separation mechanism in which phospholipid vesicles provide a supramolecular template spatially organizing multiple self-associating peptides thereby generating programmable multivalency de novo and inducing macroscopic phase separation.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1021/acs.biomac.9b00081
- OA Status
- green
- Cited By
- 4
- References
- 58
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2921046276
All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W2921046276Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1021/acs.biomac.9b00081Digital Object Identifier
- Title
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Minimal Reconstitution of Membranous Web Induced by a Vesicle–Peptide Sol–Gel TransitionWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2019Year of publication
- Publication date
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2019-03-11Full publication date if available
- Authors
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James C. S. Ho, Christoph Steininger, Shu Hui Hiew, Min Chul Kim, Erik Reimhult, Ali Miserez, Nam‐Joon Cho, Atul N. Parikh, Bo LiedbergList of authors in order
- Landing page
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https://doi.org/10.1021/acs.biomac.9b00081Publisher landing page
- Open access
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YesWhether a free full text is available
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greenOpen access status per OpenAlex
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https://dr.ntu.edu.sg/bitstream/10356/143163/2/Minimal%20Reconstitution%20of%20Membranous%20Web%20Induced%20by%20a%20Vesicle-Peptide%20Sol-Gel%20Transition.pdfDirect OA link when available
- Concepts
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Vesicle, Peptide, Chemistry, Transition (genetics), Biophysics, Biochemistry, Biology, Membrane, GeneTop concepts (fields/topics) attached by OpenAlex
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4Total citation count in OpenAlex
- Citations by year (recent)
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2024: 1, 2023: 1, 2022: 1, 2021: 1Per-year citation counts (last 5 years)
- References (count)
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58Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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