Minimal-tag probes for intracellular imaging of polyamines Article Swipe
Sas, Zuzanna
,
Zakrzewski Maciej
,
Wardak Agnieszka D.
,
Wanat Przemyslaw
,
Czestkowski, Wojciech
,
Zmorzynska, Justyna
,
Marusiak, Anna A.
,
Serwa Remigiusz A.
·
YOU?
·
· 2026
· Open Access
·
· DOI: https://doi.org/10.5281/zenodo.17529266
YOU?
·
· 2026
· Open Access
·
· DOI: https://doi.org/10.5281/zenodo.17529266
Polyamines (putrescine, spermidine, and spermine) are essential cellular polycations that regulate chromatin structure, RNA function, and organelle physiology. However, the lack of minimally perturbing probes has limited visualization of their intracellular dynamics. Here, we report the design, synthesis, and application of propargyl analogs of polyamines (iPUT, iSPD, and iSPM) as minimal-tag, bioorthogonal probes for high-resolution imaging in mammalian cells and zebrafish. These probes preserve the physicochemical features and transport compatibility of native polyamines, enabling fixation-based labeling via copper-catalyzed azide–alkyne cycloaddition (CuAAC). Imaging in MCF-7 cells revealed distinct, structure-dependent localization patterns—nuclear for iPUT and iSPD, and extranuclear/mitochondrial for iSPM. Mass spectrometry confirmed that the probes remain chemically intact within cells. Pharmacological inhibition with the polyamine transport blocker AMXT-1501 reduced probe uptake and altered subcellular distribution, confirming engagement with endogenous transport pathways. Pulse–chase experiments further demonstrated dynamic efflux and intercellular transfer of polyamines. In zebrafish larvae, iPAs displayed structure- and tissue-dependent accumulation, with striking differences between neuronal and epidermal cells and among brain regions. Together, these findings establish iPAs as versatile, minimally invasive tools for spatially resolved mapping of polyamine transport and localization in cells and whole organisms. The probes provide a foundation for future studies of polyamine-dependent signaling and metabolism in health and disease.
Related Topics
Concepts
Bioorthogonal chemistry
Intracellular
Chemistry
Cell biology
Biochemistry
Subcellular localization
Polyamine
Plasmodesma
Organelle
Biophysics
Fluorescence-lifetime imaging microscopy
Efflux
Live cell imaging
Endogeny
Chromatin
Transport protein
Förster resonance energy transfer
Membrane transport
Zebrafish
Transporter
Molecular imaging
Cell
Cell signaling
Metadata
- Type
- article
- Landing Page
- https://doi.org/10.5281/zenodo.17529266
- OA Status
- green
- OpenAlex ID
- https://openalex.org/W7104017451
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W7104017451Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.5281/zenodo.17529266Digital Object Identifier
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Minimal-tag probes for intracellular imaging of polyaminesWork title
- Type
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articleOpenAlex work type
- Publication year
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2026Year of publication
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2026-01-01Full publication date if available
- Authors
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Sas, Zuzanna, Zakrzewski Maciej, Wardak Agnieszka D., Wanat Przemyslaw, Czestkowski, Wojciech, Zmorzynska, Justyna, Marusiak, Anna A., Serwa Remigiusz A.List of authors in order
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https://doi.org/10.5281/zenodo.17529266Publisher landing page
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YesWhether a free full text is available
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greenOpen access status per OpenAlex
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https://doi.org/10.5281/zenodo.17529266Direct OA link when available
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Bioorthogonal chemistry, Intracellular, Chemistry, Cell biology, Biochemistry, Subcellular localization, Polyamine, Plasmodesma, Organelle, Biophysics, Fluorescence-lifetime imaging microscopy, Efflux, Live cell imaging, Endogeny, Chromatin, Transport protein, Förster resonance energy transfer, Membrane transport, Zebrafish, Transporter, Molecular imaging, Cell, Cell signalingTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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| publication_date | 2026-01-01 |
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