MiR-202-3p determines embryo viability during mid-blastula transition Article Swipe
Ruiqin Hu
,
Yanna Xu
,
Bingshe Han
,
Yi Chen
,
Wenhao Li
,
Guijun Guan
,
Peng Hu
,
Yan Zhou
,
Qianghua Xu
,
Liangbiao Chen
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3389/fcell.2022.897826
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3389/fcell.2022.897826
Developmental growth is an intricate process involving the coordinated regulation of the expression of various genes, and microRNAs (miRNAs) play crucial roles in diverse processes throughout animal development. The mid-blastula transition (MBT) is a developmental milestone when maternal RNAs are cleared and the zygotic genome programmed asynchronous cell division begins to drive embryogenesis. While mechanisms underlying MBT have been intensively revealed, factors regulating cell proliferation at the transition remain largely unknown. We report here a microRNA, miR-202-3p to be a key factor that determines embryonic fate during MBT in zebrafish. A miR-202-3p antagomir specifically terminated embryo development at the mid-blastula stage. In vivo deletion of the miR-202 locus recapitulated the fatal phenotypes, which were rescued only by miR-202-3p or its precursor. Transcriptome comparison revealed >250 RNAs including both maternal and zygotic origins were dysregulated at MBT in the miR-202 −/− embryos, corresponding with arrays of homeostatic disorders leading to massive apoptosis. A trio of genes: nfkbiaa , perp and mgll , known to be intimately involved with cell proliferation and survival, were identified as direct targets of miR-202-3p. Importantly, over- or under-expression of any of the trio led to developmental delay or termination at the blastula or gastrula stages. Furthermore, nfkbiaa and perp were shown to inter-regulate each other. Thus, miR-202-3p mediates a regulatory network whose components interact closely during MBT to determine embryonic viability and development.
Related Topics
Concepts
Blastula
Biology
microRNA
Zebrafish
Maternal to zygotic transition
Cell biology
Embryonic stem cell
Gastrulation
Genetics
Zygote
Epiblast
Cell fate determination
Morpholino
Embryogenesis
Embryo
Gene
Transcription factor
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fcell.2022.897826
- OA Status
- gold
- Cited By
- 3
- References
- 79
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4290546597
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4290546597Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fcell.2022.897826Digital Object Identifier
- Title
-
MiR-202-3p determines embryo viability during mid-blastula transitionWork title
- Type
-
articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
-
2022-08-08Full publication date if available
- Authors
-
Ruiqin Hu, Yanna Xu, Bingshe Han, Yi Chen, Wenhao Li, Guijun Guan, Peng Hu, Yan Zhou, Qianghua Xu, Liangbiao ChenList of authors in order
- Landing page
-
https://doi.org/10.3389/fcell.2022.897826Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.3389/fcell.2022.897826Direct OA link when available
- Concepts
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Blastula, Biology, microRNA, Zebrafish, Maternal to zygotic transition, Cell biology, Embryonic stem cell, Gastrulation, Genetics, Zygote, Epiblast, Cell fate determination, Morpholino, Embryogenesis, Embryo, Gene, Transcription factorTop concepts (fields/topics) attached by OpenAlex
- Cited by
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3Total citation count in OpenAlex
- Citations by year (recent)
-
2024: 1, 2023: 2Per-year citation counts (last 5 years)
- References (count)
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79Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.expression | 12 |
| abstract_inverted_index.identified | 172 |
| abstract_inverted_index.intimately | 164 |
| abstract_inverted_index.mechanisms | 54 |
| abstract_inverted_index.miR-202-3p | 76, 91, 117, 210 |
| abstract_inverted_index.precursor. | 120 |
| abstract_inverted_index.programmed | 45 |
| abstract_inverted_index.regulating | 62 |
| abstract_inverted_index.regulation | 9 |
| abstract_inverted_index.regulatory | 213 |
| abstract_inverted_index.terminated | 94 |
| abstract_inverted_index.throughout | 25 |
| abstract_inverted_index.transition | 30, 67 |
| abstract_inverted_index.underlying | 55 |
| abstract_inverted_index.zebrafish. | 89 |
| abstract_inverted_index.>250 | 124 |
| abstract_inverted_index.coordinated | 8 |
| abstract_inverted_index.development | 96 |
| abstract_inverted_index.homeostatic | 145 |
| abstract_inverted_index.intensively | 59 |
| abstract_inverted_index.miR-202-3p. | 177 |
| abstract_inverted_index.phenotypes, | 111 |
| abstract_inverted_index.termination | 192 |
| abstract_inverted_index.Furthermore, | 199 |
| abstract_inverted_index.Importantly, | 178 |
| abstract_inverted_index.asynchronous | 46 |
| abstract_inverted_index.development. | 27, 226 |
| abstract_inverted_index.dysregulated | 133 |
| abstract_inverted_index.mid-blastula | 29, 99 |
| abstract_inverted_index.specifically | 93 |
| abstract_inverted_index.Developmental | 0 |
| abstract_inverted_index.Transcriptome | 121 |
| abstract_inverted_index.corresponding | 141 |
| abstract_inverted_index.developmental | 34, 189 |
| abstract_inverted_index.proliferation | 64, 168 |
| abstract_inverted_index.recapitulated | 108 |
| abstract_inverted_index.embryogenesis. | 52 |
| abstract_inverted_index.inter-regulate | 206 |
| abstract_inverted_index.under-expression | 181 |
| cited_by_percentile_year.max | 96 |
| cited_by_percentile_year.min | 90 |
| corresponding_author_ids | https://openalex.org/A5032598180 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 10 |
| corresponding_institution_ids | https://openalex.org/I44675526 |
| citation_normalized_percentile.value | 0.52901034 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |